{
    "disease_id": "DOID:0111592",
    "recommended_name": {
        "id": "DOID:0111592",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0111592",
        "name": "plasminogen deficiency type I",
        "description": "A syndrome characterized by decreased serum plasminogen activity, decreased plasminogen antigen levels, and chronic mucosal pseudomembranous lesions typically manifesting as ligneous conjunctivitis that has_material_basis_in homozygous or compound heterozygous mutation in PLG on chromosome 6q26."
    },
    "synonyms": [
        {
            "id": "DOID:0111592",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111592",
            "name": "hypoplasminogenemia",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "hypoplasminogenemia",
            "description": "A rare multi-system disease characterized by markedly impaired extracellular fibrinolysis leading to the formation of ligneous (fibrin-rich) pseudomembranes on mucosae."
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "hypoplasminogenemia",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "plasminogen deficiency type 1",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "plasminogen deficiency, type 1",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "plasminogen deficiency, type I",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "type 1 plasminogen deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0009009",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "name": "ligneous conjunctivitis",
            "description": ""
        },
        {
            "id": "MIM:217090",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/217090",
            "name": "Plasminogen deficiency",
            "description": "Plasminogen deficiency"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0111592"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0111592",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111592",
            "categories": []
        },
        {
            "id": "MONDO:0009009",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009009",
            "categories": []
        },
        {
            "id": "MIM:217090",
            "database": "MIM",
            "url": "https://www.omim.org/entry/217090",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1Q890-1",
            "uniprot_ac": "F1Q890",
            "uniprot_id": "F1Q890_DANRE",
            "refseq_ac": "NP_958880",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Plasminogen",
                    "type": "recommended"
                },
                {
                    "name": "3.4.21.7",
                    "type": "synonym"
                },
                {
                    "name": "plasminogen precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "plg",
                    "type": "recommended"
                },
                {
                    "name": "plg",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb70e09",
                    "type": "synonym"
                }
            ],
            "record_id": "F1Q890-1",
            "evidence": [
                {
                    "id": "0111592",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111592"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20918-1",
            "uniprot_ac": "P20918",
            "uniprot_id": "PLMN_MOUSE",
            "refseq_ac": "NP_032903",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Plasminogen",
                    "type": "recommended"
                },
                {
                    "name": "angiostatin",
                    "type": "synonym"
                },
                {
                    "name": "plasmin heavy chain A",
                    "type": "synonym"
                },
                {
                    "name": "plasmin light chain B",
                    "type": "synonym"
                },
                {
                    "name": "plasminogen precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Plg",
                    "type": "recommended"
                },
                {
                    "name": "Pg",
                    "type": "synonym"
                },
                {
                    "name": "Plg",
                    "type": "synonym"
                }
            ],
            "record_id": "P20918-1",
            "evidence": [
                {
                    "id": "0111592",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111592"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P00747-1",
            "uniprot_ac": "P00747",
            "uniprot_id": "PLMN_HUMAN",
            "refseq_ac": "NP_000292",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Plasminogen",
                    "type": "recommended"
                },
                {
                    "name": "plasminogen isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "plasmin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PLG",
                    "type": "recommended"
                },
                {
                    "name": "HAE4",
                    "type": "synonym"
                },
                {
                    "name": "PLG",
                    "type": "synonym"
                }
            ],
            "record_id": "P00747-1",
            "evidence": [
                {
                    "id": "217090",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/217090"
                },
                {
                    "id": "0111592",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111592"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q01177-1",
            "uniprot_ac": "Q01177",
            "uniprot_id": "PLMN_RAT",
            "refseq_ac": "NP_445943",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Plasminogen",
                    "type": "recommended"
                },
                {
                    "name": "plasminogen precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Plg",
                    "type": "recommended"
                },
                {
                    "name": "Ab1-346",
                    "type": "synonym"
                },
                {
                    "name": "Plg",
                    "type": "synonym"
                }
            ],
            "record_id": "Q01177-1",
            "evidence": [
                {
                    "id": "0111592",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111592"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1Z7M5-1",
            "uniprot_ac": "A1Z7M5",
            "uniprot_id": "A1Z7M5_DROME",
            "refseq_ac": "NP_610439",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Peptidase S1 domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "CG13744-PA",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SP67",
                    "type": "recommended"
                },
                {
                    "name": "CG13744",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG13744",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG13744",
                    "type": "synonym"
                },
                {
                    "name": "SP67",
                    "type": "synonym"
                },
                {
                    "name": "c-SP67",
                    "type": "synonym"
                },
                {
                    "name": "cSP67",
                    "type": "synonym"
                }
            ],
            "record_id": "A1Z7M5-1",
            "evidence": [
                {
                    "id": "0111592",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111592"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0111592"
}