{
    "disease_id": "DOID:0090093",
    "recommended_name": {
        "id": "DOID:0090093",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0090093",
        "name": "hypogonadotropic hypogonadism 21 with or without anosmia",
        "description": "A hypogonadotropic hypogonadism that has_material_basis_in heterozygous mutation in the FLRT3 gene on 20p11, sometimes in association with mutations in other genes."
    },
    "synonyms": [
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "hypogonadotropic hypogonadism 21 with or without anosmia",
            "description": "Any hypogonadotropic hypogonadism in which the cause of the disease is a mutation in the FLRT3 gene."
        },
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "FLRT3 hypogonadotropic hypogonadism",
            "description": ""
        },
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "hypogonadotropic hypogonadism 21 with anosmia",
            "description": ""
        },
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "hypogonadotropic hypogonadism 21 with or without anosmia",
            "description": ""
        },
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "hypogonadotropic hypogonadism caused by mutation in FLRT3",
            "description": ""
        },
        {
            "id": "MONDO:0014107",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "name": "HH21",
            "description": ""
        },
        {
            "id": "MIM:615271",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/615271",
            "name": "Hypogonadotropic hypogonadism 21 with or without anosmia",
            "description": "Hypogonadotropic hypogonadism 21 with or without anosmia"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0090093"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0090093",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0090093",
            "categories": []
        },
        {
            "id": "MONDO:0014107",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014107",
            "categories": []
        },
        {
            "id": "MIM:615271",
            "database": "MIM",
            "url": "https://www.omim.org/entry/615271",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "B8A507-1",
            "uniprot_ac": "B8A507",
            "uniprot_id": "B8A507_DANRE",
            "refseq_ac": "NP_001243575",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Leucine-rich repeat transmembrane protein FLRT3",
                    "type": "recommended"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "flrt3",
                    "type": "recommended"
                },
                {
                    "name": "fb93g11",
                    "type": "synonym"
                },
                {
                    "name": "flrt3",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-24h12.1",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb75d02",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb93g11",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc10a05",
                    "type": "synonym"
                }
            ],
            "record_id": "B8A507-1",
            "evidence": [
                {
                    "id": "0090093",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090093"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8BGT1-1",
            "uniprot_ac": "Q8BGT1",
            "uniprot_id": "FLRT3_MOUSE",
            "refseq_ac": "NP_001165631",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Leucine-rich repeat transmembrane protein FLRT3",
                    "type": "recommended"
                },
                {
                    "name": "Fibronectin leucine rich transmembrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3 precursor",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Flrt3",
                    "type": "recommended"
                },
                {
                    "name": "5530600M07Rik",
                    "type": "synonym"
                },
                {
                    "name": "C430047I10Rik",
                    "type": "synonym"
                },
                {
                    "name": "Flrt3",
                    "type": "synonym"
                },
                {
                    "name": "Kiaa1469",
                    "type": "synonym"
                },
                {
                    "name": "mKIAA1469",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8BGT1-1",
            "evidence": [
                {
                    "id": "0090093",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090093"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NZU0-1",
            "uniprot_ac": "Q9NZU0",
            "uniprot_id": "FLRT3_HUMAN",
            "refseq_ac": "NP_037413",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Leucine-rich repeat transmembrane protein FLRT3",
                    "type": "recommended"
                },
                {
                    "name": "Fibronectin-like domain-containing leucine-rich transmembrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "fibronectin-like domain-containing leucine-rich transmembrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3 precursor",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FLRT3",
                    "type": "recommended"
                },
                {
                    "name": "FLRT3",
                    "type": "synonym"
                },
                {
                    "name": "HH21",
                    "type": "synonym"
                },
                {
                    "name": "KIAA1469",
                    "type": "synonym"
                },
                {
                    "name": "PRO1865",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9NZU0-1",
            "evidence": [
                {
                    "id": "615271",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/615271"
                },
                {
                    "id": "0090093",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090093"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "B1H234-1",
            "uniprot_ac": "B1H234",
            "uniprot_id": "FLRT3_RAT",
            "refseq_ac": "NP_001119763",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Leucine-rich repeat transmembrane protein FLRT3",
                    "type": "recommended"
                },
                {
                    "name": "Fibronectin-like domain-containing leucine-rich transmembrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "fibronectin-like domain-containing leucine-rich transmembrane protein 3",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3 precursor",
                    "type": "synonym"
                },
                {
                    "name": "leucine-rich repeat transmembrane protein FLRT3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Flrt3",
                    "type": "recommended"
                },
                {
                    "name": "Flrt3",
                    "type": "synonym"
                },
                {
                    "name": "RGD1566005",
                    "type": "synonym"
                }
            ],
            "record_id": "B1H234-1",
            "evidence": [
                {
                    "id": "0090093",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090093"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P28646-1",
            "uniprot_ac": "P28646",
            "uniprot_id": "SSR1_RAT",
            "refseq_ac": "NP_036851",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Somatostatin receptor type 1",
                    "type": "recommended"
                },
                {
                    "name": "RNGPCRRNA",
                    "type": "synonym"
                },
                {
                    "name": "SRIF-2",
                    "type": "synonym"
                },
                {
                    "name": "SS-1-R",
                    "type": "synonym"
                },
                {
                    "name": "SS1-R",
                    "type": "synonym"
                },
                {
                    "name": "SS1R",
                    "type": "synonym"
                },
                {
                    "name": "Somatostatin receptor subtype 1",
                    "type": "synonym"
                },
                {
                    "name": "somatostatin receptor type 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sstr1",
                    "type": "recommended"
                },
                {
                    "name": "Gpcrrna",
                    "type": "synonym"
                },
                {
                    "name": "Sstr1",
                    "type": "synonym"
                }
            ],
            "record_id": "P28646-1",
            "evidence": [
                {
                    "id": "0090093",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0090093"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0090093"
}