{
    "disease_id": "DOID:0081013",
    "recommended_name": {
        "id": "DOID:0081013",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0081013",
        "name": "severe COVID-19",
        "description": "A COVID-19 that is characterized by any of (1) Oxygen saturation < 90% on room air, (2) Respiratory rate > 30 breaths/min in adults and children > 5 years old,  60 breaths/min in children < 2 months old,  50 in children 211 months old, and  40 in children 15 years old, or (3) signs of severe respiratory distress (accessory muscle use, inability to complete full sentences, and, in children, very severe chest wall indrawing, grunting, central cyanosis, or presence of any other general danger signs."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0081013"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0081013",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0081013",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A2R8Q9M5-1",
            "uniprot_ac": "A0A2R8Q9M5",
            "uniprot_id": "A0A2R8Q9M5_DANRE",
            "refseq_ac": "NP_001373638",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 8b precursor",
                    "type": "synonym"
                },
                {
                    "name": "toll-like receptor 8b precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "tlr8b",
                    "type": "recommended"
                },
                {
                    "name": "TIR8.1",
                    "type": "synonym"
                },
                {
                    "name": "tlr8b",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A2R8Q9M5-1",
            "evidence": [
                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q99MB1-1",
            "uniprot_ac": "Q99MB1",
            "uniprot_id": "TLR3_MOUSE",
            "refseq_ac": "NP_569054",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr3",
                    "type": "recommended"
                },
                {
                    "name": "Tlr3",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
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            "uniprot_canonical_ac": "P58682-1",
            "uniprot_ac": "P58682",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 8",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 8 isoform 2 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr8",
                    "type": "recommended"
                },
                {
                    "name": "Tlr8",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Toll-like receptor 7",
                    "type": "recommended"
                },
                {
                    "name": "Toll like receptor 7",
                    "type": "synonym"
                },
                {
                    "name": "toll-like receptor 7 isoform a precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr7",
                    "type": "recommended"
                },
                {
                    "name": "Tlr7",
                    "type": "synonym"
                }
            ],
            "record_id": "P58681-1",
            "evidence": [
                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1LN63-1",
            "uniprot_ac": "F1LN63",
            "uniprot_id": "F1LN63_RAT",
            "refseq_ac": "NP_942086",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
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                }
            ],
            "gene_names": [
                {
                    "name": "Tlr3",
                    "type": "recommended"
                },
                {
                    "name": "Tlr3",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8I6GHR4-1",
            "uniprot_ac": "A0A8I6GHR4",
            "uniprot_id": "A0A8I6GHR4_RAT",
            "refseq_ac": "XP_017457568",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 7",
                    "type": "synonym"
                },
                {
                    "name": "toll-like receptor 7 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr7",
                    "type": "recommended"
                },
                {
                    "name": "RGD1563357",
                    "type": "synonym"
                },
                {
                    "name": "Tlr7",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8I6GHR4-1",
            "evidence": [
                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VPH1-1",
            "uniprot_ac": "Q9VPH1",
            "uniprot_id": "Q9VPH1_DROME",
            "refseq_ac": "NP_001246846",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG5528-PC",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9-PC",
                    "type": "synonym"
                },
                {
                    "name": "toll receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Toll-9",
                    "type": "recommended"
                },
                {
                    "name": "CG5528",
                    "type": "synonym"
                },
                {
                    "name": "CT17508",
                    "type": "synonym"
                },
                {
                    "name": "Dm Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5528",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5528",
                    "type": "synonym"
                },
                {
                    "name": "TOLL 9",
                    "type": "synonym"
                },
                {
                    "name": "Tak/Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Tl-5",
                    "type": "synonym"
                },
                {
                    "name": "Tl-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll 9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-6",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Toll9",
                    "type": "synonym"
                },
                {
                    "name": "Toll",
                    "type": "synonym"
                },
                {
                    "name": "dTLR9",
                    "type": "synonym"
                },
                {
                    "name": "dToll9",
                    "type": "synonym"
                },
                {
                    "name": "toll",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VPH1-1",
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1Z9N6-1",
            "uniprot_ac": "A1Z9N6",
            "uniprot_id": "A1Z9N6_DROME",
            "refseq_ac": "NP_001286416",
            "glycoprotein": "no",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Acid-labile subunit",
                    "type": "synonym"
                },
                {
                    "name": "CG8561-PB",
                    "type": "synonym"
                },
                {
                    "name": "Convoluted, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Convoluted, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "acid labile substrate",
                    "type": "synonym"
                },
                {
                    "name": "acid labile subunit",
                    "type": "synonym"
                },
                {
                    "name": "conv-PB",
                    "type": "synonym"
                },
                {
                    "name": "convoluted, isoform B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "conv",
                    "type": "recommended"
                },
                {
                    "name": "ALS",
                    "type": "synonym"
                },
                {
                    "name": "Als",
                    "type": "synonym"
                },
                {
                    "name": "CG8561",
                    "type": "synonym"
                },
                {
                    "name": "CT24963",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8561",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8561",
                    "type": "synonym"
                },
                {
                    "name": "capricious-like",
                    "type": "synonym"
                },
                {
                    "name": "conv",
                    "type": "synonym"
                },
                {
                    "name": "dALS",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k06507b",
                    "type": "synonym"
                },
                {
                    "name": "tartan/capricious-like",
                    "type": "synonym"
                }
            ],
            "record_id": "A1Z9N6-1",
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NYK1-1",
            "uniprot_ac": "Q9NYK1",
            "uniprot_id": "TLR7_HUMAN",
            "refseq_ac": "NP_057646",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 7",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 7 precursor",
                    "type": "synonym"
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                {
                    "name": "toll-like receptor 7-like",
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            ],
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                {
                    "name": "TLR7",
                    "type": "recommended"
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                {
                    "name": "IMD74",
                    "type": "synonym"
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                {
                    "name": "PRO285",
                    "type": "synonym"
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                {
                    "name": "SLEB17",
                    "type": "synonym"
                },
                {
                    "name": "TLR7-like",
                    "type": "synonym"
                },
                {
                    "name": "TLR7",
                    "type": "synonym"
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            ],
            "record_id": "Q9NYK1-1",
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NR97-1",
            "uniprot_ac": "Q9NR97",
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            "refseq_ac": "NP_057694",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 8",
                    "type": "recommended"
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                {
                    "name": "toll-like receptor 8 isoform 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TLR8",
                    "type": "recommended"
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                {
                    "name": "CD288",
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                },
                {
                    "name": "IMD98",
                    "type": "synonym"
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                {
                    "name": "PRO286",
                    "type": "synonym"
                },
                {
                    "name": "TLR-8",
                    "type": "synonym"
                },
                {
                    "name": "TLR8",
                    "type": "synonym"
                },
                {
                    "name": "hTLR8",
                    "type": "synonym"
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            ],
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                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O15455-1",
            "uniprot_ac": "O15455",
            "uniprot_id": "TLR3_HUMAN",
            "refseq_ac": "NP_003256",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TLR3",
                    "type": "recommended"
                },
                {
                    "name": "CD283",
                    "type": "synonym"
                },
                {
                    "name": "IIAE2",
                    "type": "synonym"
                },
                {
                    "name": "IMD83",
                    "type": "synonym"
                },
                {
                    "name": "TLR3",
                    "type": "synonym"
                }
            ],
            "record_id": "O15455-1",
            "evidence": [
                {
                    "id": "0081013",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081013"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0081013"
}