{
    "disease_id": "DOID:0080883",
    "recommended_name": {
        "id": "DOID:0080883",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080883",
        "name": "vitamin D-dependent rickets",
        "description": "A bone development disease that is characterized by softening and weakening of the bones, hypocalcemia, high levels of parathyroid hormone and hypophosphatemia."
    },
    "synonyms": [],
    "children": [
        {
            "id": "DOID:0080884",
            "label": "vitamin D-dependent rickets type 2A",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0080886",
            "label": "vitamin D-dependent rickets type 1A",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0080887",
            "label": "vitamin D-dependent rickets type 1B",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0080887",
        "DOID:0080883",
        "DOID:0080886",
        "DOID:0080884"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080883",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080883",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A0G2KYH9-1",
            "uniprot_ac": "A0A0G2KYH9",
            "uniprot_id": "A0A0G2KYH9_DANRE",
            "refseq_ac": "XP_001342606",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cxcl8a",
                    "type": "recommended"
                },
                {
                    "name": "cxcl8a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A0G2KYH9-1",
            "evidence": [
                {
                    "id": "0080883",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9PTN2-1",
            "uniprot_ac": "Q9PTN2",
            "uniprot_id": "VDRA_DANRE",
            "refseq_ac": "NP_570994",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin D3 receptor A",
                    "type": "recommended"
                },
                {
                    "name": "1,25-dihydroxyvitamin D3 receptor A",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group I member 1-A",
                    "type": "synonym"
                },
                {
                    "name": "VDR-A",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group I member 1-A",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D (1,25- dihydroxyvitamin D3) receptor a",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D3 receptor A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "vdra",
                    "type": "recommended"
                },
                {
                    "name": "NR1I1-A",
                    "type": "synonym"
                },
                {
                    "name": "VDR-A",
                    "type": "synonym"
                },
                {
                    "name": "VDRalpha",
                    "type": "synonym"
                },
                {
                    "name": "nr1i1a",
                    "type": "synonym"
                },
                {
                    "name": "vdra",
                    "type": "synonym"
                },
                {
                    "name": "vdr",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9PTN2-1",
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                {
                    "id": "0080883",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P48281-1",
            "uniprot_ac": "P48281",
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            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Vitamin D3 receptor",
                    "type": "recommended"
                },
                {
                    "name": "1,25-dihydroxyvitamin D3 receptor",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group I member 1",
                    "type": "synonym"
                },
                {
                    "name": "VDR",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group I member 1",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D receptor",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D3 receptor",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Vdr",
                    "type": "recommended"
                },
                {
                    "name": "Nr1i1",
                    "type": "synonym"
                },
                {
                    "name": "Vdr",
                    "type": "synonym"
                }
            ],
            "record_id": "P48281-1",
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                {
                    "id": "0080883",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P13053-1",
            "uniprot_ac": "P13053",
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            "refseq_ac": "NP_058754",
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            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Vitamin D3 receptor",
                    "type": "recommended"
                },
                {
                    "name": "1,25-dihydroxyvitamin D3 receptor",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group I member 1",
                    "type": "synonym"
                },
                {
                    "name": "VDR",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group I member 1",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D (1,25- dihydroxyvitamin D3) receptor",
                    "type": "synonym"
                },
                {
                    "name": "vitamin D3 receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Vdr",
                    "type": "recommended"
                },
                {
                    "name": "Nr1i1",
                    "type": "synonym"
                },
                {
                    "name": "Vdr",
                    "type": "synonym"
                }
            ],
            "record_id": "P13053-1",
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                {
                    "id": "0080883",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q24143-1",
            "uniprot_ac": "Q24143",
            "uniprot_id": "HR96_DROME",
            "refseq_ac": "NP_524493",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nuclear hormone receptor HR96",
                    "type": "recommended"
                },
                {
                    "name": "CG11783-PA",
                    "type": "synonym"
                },
                {
                    "name": "Hr96-PA",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group J member 1",
                    "type": "synonym"
                },
                {
                    "name": "dHR96",
                    "type": "synonym"
                },
                {
                    "name": "hormone receptor-like in 96",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Hr96",
                    "type": "recommended"
                },
                {
                    "name": "CG11783",
                    "type": "synonym"
                },
                {
                    "name": "DHR96",
                    "type": "synonym"
                },
                {
                    "name": "Dhr96",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG11783",
                    "type": "synonym"
                },
                {
                    "name": "HR96",
                    "type": "synonym"
                },
                {
                    "name": "Hr96",
                    "type": "synonym"
                },
                {
                    "name": "NR1J1",
                    "type": "synonym"
                },
                {
                    "name": "dHR96",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0080883",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q92765-1",
            "uniprot_ac": "Q92765",
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            "refseq_ac": "NP_001454",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Secreted frizzled-related protein 3",
                    "type": "recommended"
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                {
                    "name": "Frezzled",
                    "type": "synonym"
                },
                {
                    "name": "Fritz",
                    "type": "synonym"
                },
                {
                    "name": "Frizzled-related protein 1",
                    "type": "synonym"
                },
                {
                    "name": "FrzB-1",
                    "type": "synonym"
                },
                {
                    "name": "frezzled",
                    "type": "synonym"
                },
                {
                    "name": "frizzled homolog-related",
                    "type": "synonym"
                },
                {
                    "name": "frizzled-related protein 1",
                    "type": "synonym"
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                {
                    "name": "sFRP-3",
                    "type": "synonym"
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                {
                    "name": "secreted frizzled-related protein 3 precursor",
                    "type": "synonym"
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                {
                    "name": "secreted frizzled-related protein 3",
                    "type": "synonym"
                }
            ],
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                    "name": "FRZB",
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                    "name": "FIZ",
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                },
                {
                    "name": "FRE",
                    "type": "synonym"
                },
                {
                    "name": "FRITZ",
                    "type": "synonym"
                },
                {
                    "name": "FRP-3",
                    "type": "synonym"
                },
                {
                    "name": "FRP",
                    "type": "synonym"
                },
                {
                    "name": "FRZB-1",
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                },
                {
                    "name": "FRZB-PEN",
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                {
                    "name": "FRZB1",
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                {
                    "name": "FRZB",
                    "type": "synonym"
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                {
                    "name": "FZRB",
                    "type": "synonym"
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                {
                    "name": "OS1",
                    "type": "synonym"
                },
                {
                    "name": "SFRP3",
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                {
                    "name": "SRFP3",
                    "type": "synonym"
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                {
                    "name": "hFIZ",
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            ],
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                    "id": "0080883",
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            ]
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                    "name": "Homo sapiens",
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                }
            ],
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                {
                    "name": "Interleukin-8",
                    "type": "recommended"
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                    "name": "(Ala-IL-8)77",
                    "type": "synonym"
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                {
                    "name": "(Ser-IL-8)72",
                    "type": "synonym"
                },
                {
                    "name": "C-X-C motif chemokine 8",
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                {
                    "name": "Chemokine (C-X-C motif) ligand 8",
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                {
                    "name": "Emoctakin",
                    "type": "synonym"
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                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein III",
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                {
                    "name": "GCP/IL-8 protein II",
                    "type": "synonym"
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                {
                    "name": "GCP/IL-8 protein IV",
                    "type": "synonym"
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                {
                    "name": "GCP/IL-8 protein I",
                    "type": "synonym"
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                {
                    "name": "GCP/IL-8 protein VI",
                    "type": "synonym"
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                {
                    "name": "GCP/IL-8 protein V",
                    "type": "synonym"
                },
                {
                    "name": "Granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IL-8(1-77)",
                    "type": "synonym"
                },
                {
                    "name": "IL-8",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form III",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form II",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form IV",
                    "type": "synonym"
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                {
                    "name": "IL8/NAP1 form I",
                    "type": "synonym"
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                {
                    "name": "IL8/NAP1 form VI",
                    "type": "synonym"
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                {
                    "name": "IL8/NAP1 form V",
                    "type": "synonym"
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                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte-derived neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-b",
                    "type": "synonym"
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                {
                    "name": "MDNCF-c",
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                {
                    "name": "MDNCF",
                    "type": "synonym"
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                {
                    "name": "MONAP",
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                {
                    "name": "Monocyte-derived neutrophil chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil-activating peptide",
                    "type": "synonym"
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                {
                    "name": "NAF",
                    "type": "synonym"
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                {
                    "name": "NAP-1",
                    "type": "synonym"
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                {
                    "name": "Neutrophil-activating factor",
                    "type": "synonym"
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                {
                    "name": "Neutrophil-activating protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Protein 3-10C",
                    "type": "synonym"
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                {
                    "name": "T-cell chemotactic factor",
                    "type": "synonym"
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                {
                    "name": "alveolar macrophage chemotactic factor I",
                    "type": "synonym"
                },
                {
                    "name": "beta endothelial cell-derived neutrophil activating peptide",
                    "type": "synonym"
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                {
                    "name": "beta-thromboglobulin-like protein",
                    "type": "synonym"
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                {
                    "name": "chemokine (C-X-C motif) ligand 8",
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                    "name": "emoctakin",
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                {
                    "name": "granulocyte chemotactic protein 1",
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                {
                    "name": "interleukin 8",
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                {
                    "name": "interleukin-8 isoform 1 precursor",
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                {
                    "name": "lung giant cell carcinoma-derived chemotactic protein",
                    "type": "synonym"
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                {
                    "name": "lymphocyte derived neutrophil activating peptide",
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                    "name": "monocyte-derived neutrophil chemotactic factor",
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                {
                    "name": "monocyte-derived neutrophil-activating peptide",
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                {
                    "name": "neutrophil-activating peptide 1",
                    "type": "synonym"
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                {
                    "name": "small inducible cytokine subfamily B, member 8",
                    "type": "synonym"
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                {
                    "name": "tumor necrosis factor-induced gene 1",
                    "type": "synonym"
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                    "name": "CXCL8",
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                    "name": "CXCL8",
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                    "name": "GCP1",
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                    "name": "IL8",
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                    "name": "LECT",
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                    "name": "LUCT",
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                    "name": "LYNAP",
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                    "name": "MDNCF",
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                    "name": "SCYB8",
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                    "id": "0080883",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
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                    "name": "Homo sapiens",
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                }
            ],
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                    "name": "Vitamin D3 receptor",
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                    "name": "1,25-dihydroxyvitamin D3 receptor",
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                {
                    "name": "Nuclear receptor subfamily 1 group I member 1",
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                    "name": "VDR",
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                {
                    "name": "nuclear receptor subfamily 1 group I member 1",
                    "type": "synonym"
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                {
                    "name": "protein phosphatase 1, regulatory subunit 163",
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                {
                    "name": "vitamin D (1,25- dihydroxyvitamin D3) receptor",
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                {
                    "name": "vitamin D3 receptor isoform VDRA",
                    "type": "synonym"
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                {
                    "name": "vitamin D3 receptor",
                    "type": "synonym"
                }
            ],
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                    "name": "VDR",
                    "type": "recommended"
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                {
                    "name": "NR1I1",
                    "type": "synonym"
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                {
                    "name": "PPP1R163",
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                {
                    "name": "VDR",
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                }
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                    "id": "0080883",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080883"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080883"
}