{
    "disease_id": "DOID:0080860",
    "recommended_name": {
        "id": "DOID:0080860",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080860",
        "name": "primary ovarian insufficiency 3",
        "description": "A primary ovarian insufficiency characterized by the cessation of ovarian function before the age of 40 years, with amenorrhea, hypoestrogenism, and elevated serum gonadotropin concentrations that has_material_basis_in heterozygous mutation in the FOXL2 gene on chromosome 3q22."
    },
    "synonyms": [
        {
            "id": "MONDO:0012169",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012169",
            "name": "premature ovarian failure 3",
            "description": ""
        },
        {
            "id": "MONDO:0012169",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012169",
            "name": "premature ovarian failure 3",
            "description": ""
        },
        {
            "id": "MONDO:0012169",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012169",
            "name": "premature ovarian failure type 3",
            "description": ""
        },
        {
            "id": "MONDO:0012169",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012169",
            "name": "Pof3",
            "description": ""
        },
        {
            "id": "MIM:608996",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/608996",
            "name": "Premature ovarian failure 3",
            "description": "Premature ovarian failure 3"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080860"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080860",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080860",
            "categories": []
        },
        {
            "id": "MONDO:0012169",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012169",
            "categories": []
        },
        {
            "id": "MIM:608996",
            "database": "MIM",
            "url": "https://www.omim.org/entry/608996",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "O88470-1",
            "uniprot_ac": "O88470",
            "uniprot_id": "FOXL2_MOUSE",
            "refseq_ac": "NP_036150",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Forkhead box protein L2",
                    "type": "recommended"
                },
                {
                    "name": "P-Frk",
                    "type": "synonym"
                },
                {
                    "name": "Pituitary forkhead factor",
                    "type": "synonym"
                },
                {
                    "name": "forkhead box protein L2",
                    "type": "synonym"
                },
                {
                    "name": "pituitary forkhead factor",
                    "type": "synonym"
                },
                {
                    "name": "putative transcription factor foxl2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Foxl2",
                    "type": "recommended"
                },
                {
                    "name": "BPES",
                    "type": "synonym"
                },
                {
                    "name": "Foxl2",
                    "type": "synonym"
                },
                {
                    "name": "P-Frk",
                    "type": "synonym"
                },
                {
                    "name": "PINTO",
                    "type": "synonym"
                },
                {
                    "name": "Pfrk",
                    "type": "synonym"
                }
            ],
            "record_id": "O88470-1",
            "evidence": [
                {
                    "id": "0080860",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080860"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P58012-1",
            "uniprot_ac": "P58012",
            "uniprot_id": "FOXL2_HUMAN",
            "refseq_ac": "NP_075555",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Forkhead box protein L2",
                    "type": "recommended"
                },
                {
                    "name": "forkhead box protein L2",
                    "type": "synonym"
                },
                {
                    "name": "forkhead transcription factor FOXL2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FOXL2",
                    "type": "recommended"
                },
                {
                    "name": "BPES1",
                    "type": "synonym"
                },
                {
                    "name": "BPES",
                    "type": "synonym"
                },
                {
                    "name": "FOXL2",
                    "type": "synonym"
                },
                {
                    "name": "PFRK",
                    "type": "synonym"
                },
                {
                    "name": "PINTO",
                    "type": "synonym"
                },
                {
                    "name": "POF3",
                    "type": "synonym"
                }
            ],
            "record_id": "P58012-1",
            "evidence": [
                {
                    "id": "608996",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/608996"
                },
                {
                    "id": "0080860",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080860"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P25364-1",
            "uniprot_ac": "P25364",
            "uniprot_id": "HCM1_YEAST",
            "refseq_ac": "NP_009991",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Forkhead transcription factor HCM1",
                    "type": "recommended"
                },
                {
                    "name": "Hcm1p",
                    "type": "synonym"
                },
                {
                    "name": "High-copy suppressor of calmodulin protein 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HCM1",
                    "type": "recommended"
                },
                {
                    "name": "HCM1",
                    "type": "synonym"
                },
                {
                    "name": "YCR65W",
                    "type": "synonym"
                },
                {
                    "name": "YCR902",
                    "type": "synonym"
                }
            ],
            "record_id": "P25364-1",
            "evidence": [
                {
                    "id": "0080860",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080860"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ABK0LZJ6-1",
            "uniprot_ac": "A0ABK0LZJ6",
            "uniprot_id": "A0ABK0LZJ6_RAT",
            "refseq_ac": "NP_001414120",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Forkhead box protein L2",
                    "type": "recommended"
                },
                {
                    "name": "forkhead box protein L2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Foxl2",
                    "type": "recommended"
                },
                {
                    "name": "Foxl2",
                    "type": "synonym"
                }
            ],
            "record_id": "A0ABK0LZJ6-1",
            "evidence": [
                {
                    "id": "0080860",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080860"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P32030-1",
            "uniprot_ac": "P32030",
            "uniprot_id": "SLP1_DROME",
            "refseq_ac": "NP_476730",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Fork head domain transcription factor slp1",
                    "type": "recommended"
                },
                {
                    "name": "CG16738-PA",
                    "type": "synonym"
                },
                {
                    "name": "Sloppy paired locus protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Sloppy-paired1",
                    "type": "synonym"
                },
                {
                    "name": "Sloppy-paired",
                    "type": "synonym"
                },
                {
                    "name": "sloppy paired 1",
                    "type": "synonym"
                },
                {
                    "name": "sloppy paired",
                    "type": "synonym"
                },
                {
                    "name": "sloppy-paired 1",
                    "type": "synonym"
                },
                {
                    "name": "sloppy-paired-1",
                    "type": "synonym"
                },
                {
                    "name": "slp1-PA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "slp1",
                    "type": "recommended"
                },
                {
                    "name": "CG16738",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG16738",
                    "type": "synonym"
                },
                {
                    "name": "Dmslp1",
                    "type": "synonym"
                },
                {
                    "name": "FD6",
                    "type": "synonym"
                },
                {
                    "name": "FoxG",
                    "type": "synonym"
                },
                {
                    "name": "SLP1",
                    "type": "synonym"
                },
                {
                    "name": "SLP",
                    "type": "synonym"
                },
                {
                    "name": "Sloppy-paired",
                    "type": "synonym"
                },
                {
                    "name": "Slp-1",
                    "type": "synonym"
                },
                {
                    "name": "Slp1",
                    "type": "synonym"
                },
                {
                    "name": "Slp",
                    "type": "synonym"
                },
                {
                    "name": "l(2)05965",
                    "type": "synonym"
                },
                {
                    "name": "sko1",
                    "type": "synonym"
                },
                {
                    "name": "slp 1",
                    "type": "synonym"
                },
                {
                    "name": "slp-1",
                    "type": "synonym"
                },
                {
                    "name": "slp-2",
                    "type": "synonym"
                },
                {
                    "name": "slp1",
                    "type": "synonym"
                },
                {
                    "name": "slp",
                    "type": "synonym"
                }
            ],
            "record_id": "P32030-1",
            "evidence": [
                {
                    "id": "0080860",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080860"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080860"
}