{
    "disease_id": "DOID:0080846",
    "recommended_name": {
        "id": "DOID:0080846",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080846",
        "name": "latent autoimmune diabetes in adults",
        "description": "A type 1 diabetes mellitus that is characterized by a less intensive autoimmune process, highly variable -cell destruction, different degrees of insulin resistance and heterogeneous titre and pattern of islet autoantibody, sharing features with both type 1 and type 2 diabetes mellitus."
    },
    "synonyms": [
        {
            "id": "DOID:0080846",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080846",
            "name": "LADA",
            "description": ""
        },
        {
            "id": "DOID:0080846",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080846",
            "name": "type 1.5 diabetes",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080846"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080846",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080846",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P09793-1",
            "uniprot_ac": "P09793",
            "uniprot_id": "CTLA4_MOUSE",
            "refseq_ac": "NP_033973",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytotoxic T-lymphocyte protein 4",
                    "type": "recommended"
                },
                {
                    "name": "CD152 antigen",
                    "type": "synonym"
                },
                {
                    "name": "CTLA-4",
                    "type": "synonym"
                },
                {
                    "name": "Cytotoxic T-lymphocyte-associated antigen 4",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte protein 4 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte protein 4",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte-associated antigen 4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ctla4",
                    "type": "recommended"
                },
                {
                    "name": "Cd152",
                    "type": "synonym"
                },
                {
                    "name": "Ctla-4",
                    "type": "synonym"
                },
                {
                    "name": "Ctla4",
                    "type": "synonym"
                },
                {
                    "name": "Ly-56",
                    "type": "synonym"
                }
            ],
            "record_id": "P09793-1",
            "evidence": [
                {
                    "id": "0080846",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080846"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A096MJE4-1",
            "uniprot_ac": "A0A096MJE4",
            "uniprot_id": "A0A096MJE4_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytotoxic T-lymphocyte protein 4",
                    "type": "recommended"
                },
                {
                    "name": "Cytotoxic T-lymphocyte-associated antigen 4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ctla4",
                    "type": "recommended"
                }
            ],
            "record_id": "A0A096MJE4-1",
            "evidence": [
                {
                    "id": "0080846",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080846"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62696-1",
            "uniprot_ac": "Q62696",
            "uniprot_id": "DLG1_RAT",
            "refseq_ac": "NP_036920",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Disks large homolog 1",
                    "type": "recommended"
                },
                {
                    "name": "Drosophila discs-large tumor suppressor homologue (synapse associated protein)",
                    "type": "synonym"
                },
                {
                    "name": "SAP-97",
                    "type": "synonym"
                },
                {
                    "name": "SAP97",
                    "type": "synonym"
                },
                {
                    "name": "Synapse-associated protein 97",
                    "type": "synonym"
                },
                {
                    "name": "discs large homolog 1, scribble cell polarity complex component",
                    "type": "synonym"
                },
                {
                    "name": "discs, large homolog 1",
                    "type": "synonym"
                },
                {
                    "name": "disks large homolog 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "disks large homolog 1",
                    "type": "synonym"
                },
                {
                    "name": "synapse-associated protein 97",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dlg1",
                    "type": "recommended"
                },
                {
                    "name": "Dlg1",
                    "type": "synonym"
                },
                {
                    "name": "Dlgh1",
                    "type": "synonym"
                },
                {
                    "name": "SAP97",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62696-1",
            "evidence": [
                {
                    "id": "0080846",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080846"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P16410-1",
            "uniprot_ac": "P16410",
            "uniprot_id": "CTLA4_HUMAN",
            "refseq_ac": "NP_001032720",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytotoxic T-lymphocyte protein 4",
                    "type": "recommended"
                },
                {
                    "name": "CTLA-4",
                    "type": "synonym"
                },
                {
                    "name": "Cytotoxic T-lymphocyte-associated antigen 4",
                    "type": "synonym"
                },
                {
                    "name": "celiac disease 3",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T lymphocyte associated antigen 4 short spliced form",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM precursor",
                    "type": "synonym"
                },
                {
                    "name": "cytotoxic T-lymphocyte-associated serine esterase-4",
                    "type": "synonym"
                },
                {
                    "name": "gluten-sensitive enteropathy",
                    "type": "synonym"
                },
                {
                    "name": "insulin-dependent diabetes mellitus 12",
                    "type": "synonym"
                },
                {
                    "name": "ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CTLA4",
                    "type": "recommended"
                },
                {
                    "name": "ALPS5",
                    "type": "synonym"
                },
                {
                    "name": "CD152",
                    "type": "synonym"
                },
                {
                    "name": "CD",
                    "type": "synonym"
                },
                {
                    "name": "CELIAC3",
                    "type": "synonym"
                },
                {
                    "name": "CTLA-4",
                    "type": "synonym"
                },
                {
                    "name": "CTLA4",
                    "type": "synonym"
                },
                {
                    "name": "GRD4",
                    "type": "synonym"
                },
                {
                    "name": "GSE",
                    "type": "synonym"
                },
                {
                    "name": "IDDM12",
                    "type": "synonym"
                }
            ],
            "record_id": "P16410-1",
            "evidence": [
                {
                    "id": "0080846",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080846"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P05231-1",
            "uniprot_ac": "P05231",
            "uniprot_id": "IL6_HUMAN",
            "refseq_ac": "NP_000591",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-6",
                    "type": "recommended"
                },
                {
                    "name": "B-cell differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "B-cell stimulatory factor 2",
                    "type": "synonym"
                },
                {
                    "name": "BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "CDF",
                    "type": "synonym"
                },
                {
                    "name": "CTL differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "Hybridoma growth factor",
                    "type": "synonym"
                },
                {
                    "name": "IFN-beta-2",
                    "type": "synonym"
                },
                {
                    "name": "IL-6",
                    "type": "synonym"
                },
                {
                    "name": "Interferon beta-2",
                    "type": "synonym"
                },
                {
                    "name": "hybridoma growth factor",
                    "type": "synonym"
                },
                {
                    "name": "interferon beta-2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-6 isoform 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IL6",
                    "type": "recommended"
                },
                {
                    "name": "BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "BSF2",
                    "type": "synonym"
                },
                {
                    "name": "CDF",
                    "type": "synonym"
                },
                {
                    "name": "HGF",
                    "type": "synonym"
                },
                {
                    "name": "HSF",
                    "type": "synonym"
                },
                {
                    "name": "IFN-beta-2",
                    "type": "synonym"
                },
                {
                    "name": "IFNB2",
                    "type": "synonym"
                },
                {
                    "name": "IL-6",
                    "type": "synonym"
                },
                {
                    "name": "IL6",
                    "type": "synonym"
                }
            ],
            "record_id": "P05231-1",
            "evidence": [
                {
                    "id": "31772933",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31772933"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [
        {
            "biomarker_id": "AN6278-3",
            "biomarker_canonical_id": "AN6278",
            "best_biomarker_role": [
                {
                    "role": "risk"
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Interleukin-6",
                        "synonyms": [
                            {
                                "synonym": "Interferon beta-2"
                            },
                            {
                                "synonym": "IFN-beta-2"
                            },
                            {
                                "synonym": "CTL differentiation factor"
                            },
                            {
                                "synonym": "CDF"
                            },
                            {
                                "synonym": "B-cell stimulatory factor 2"
                            },
                            {
                                "synonym": "BSF-2"
                            },
                            {
                                "synonym": "Hybridoma growth factor"
                            }
                        ]
                    },
                    "biomarker": "increased IL6 level",
                    "assessed_biomarker_entity_id": "P05231-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "31772933",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/31772933"
                }
            ]
        }
    ],
    "association_flag": "1010",
    "record_id": "doid.0080846"
}