{
    "disease_id": "DOID:0080771",
    "recommended_name": {
        "id": "DOID:0080771",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080771",
        "name": "beta-thalassemia major",
        "description": "A beta thalassemia that is characterized by severe anemia and enlarged liver and spleen before 2 years of age."
    },
    "synonyms": [
        {
            "id": "DOID:0080771",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080771",
            "name": "Cooley's anemia",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080771"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080771",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080771",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P52430-1",
            "uniprot_ac": "P52430",
            "uniprot_id": "PON1_MOUSE",
            "refseq_ac": "NP_035264",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serum paraoxonase/arylesterase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "3.1.1.81",
                    "type": "synonym"
                },
                {
                    "name": "3.1.8.1",
                    "type": "synonym"
                },
                {
                    "name": "A-esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "Aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "PON 1",
                    "type": "synonym"
                },
                {
                    "name": "Serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "serum paraoxonase/arylesterase 1 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "serum paraoxonase/arylesterase 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Pon1",
                    "type": "recommended"
                },
                {
                    "name": "Pon1",
                    "type": "synonym"
                },
                {
                    "name": "Pon",
                    "type": "synonym"
                }
            ],
            "record_id": "P52430-1",
            "evidence": [
                {
                    "id": "0080771",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080771"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P55159-1",
            "uniprot_ac": "P55159",
            "uniprot_id": "PON1_RAT",
            "refseq_ac": "NP_114466",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serum paraoxonase/arylesterase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "3.1.1.81",
                    "type": "synonym"
                },
                {
                    "name": "3.1.8.1",
                    "type": "synonym"
                },
                {
                    "name": "A-esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "Aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "PON 1",
                    "type": "synonym"
                },
                {
                    "name": "Serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "serum paraoxonase/arylesterase 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Pon1",
                    "type": "recommended"
                },
                {
                    "name": "Pon1",
                    "type": "synonym"
                },
                {
                    "name": "Pon",
                    "type": "synonym"
                }
            ],
            "record_id": "P55159-1",
            "evidence": [
                {
                    "id": "0080771",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080771"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P27169-1",
            "uniprot_ac": "P27169",
            "uniprot_id": "PON1_HUMAN",
            "refseq_ac": "NP_000437",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serum paraoxonase/arylesterase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "3.1.1.81",
                    "type": "synonym"
                },
                {
                    "name": "3.1.8.1",
                    "type": "synonym"
                },
                {
                    "name": "A-esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "Aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "K-45",
                    "type": "synonym"
                },
                {
                    "name": "PON 1",
                    "type": "synonym"
                },
                {
                    "name": "Serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "aromatic esterase 1",
                    "type": "synonym"
                },
                {
                    "name": "arylesterase 1",
                    "type": "synonym"
                },
                {
                    "name": "arylesterase B-type",
                    "type": "synonym"
                },
                {
                    "name": "esterase A",
                    "type": "synonym"
                },
                {
                    "name": "paraoxonase B-type",
                    "type": "synonym"
                },
                {
                    "name": "serum aryldiakylphosphatase",
                    "type": "synonym"
                },
                {
                    "name": "serum aryldialkylphosphatase 1",
                    "type": "synonym"
                },
                {
                    "name": "serum paraoxonase/arylesterase 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PON1",
                    "type": "recommended"
                },
                {
                    "name": "ESA",
                    "type": "synonym"
                },
                {
                    "name": "MVCD5",
                    "type": "synonym"
                },
                {
                    "name": "PON1",
                    "type": "synonym"
                },
                {
                    "name": "PON",
                    "type": "synonym"
                }
            ],
            "record_id": "P27169-1",
            "evidence": [
                {
                    "id": "0080771",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080771"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080771"
}