{
    "disease_id": "DOID:0080744",
    "recommended_name": {
        "id": "DOID:0080744",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080744",
        "name": "antisynthetase syndrome",
        "description": "An autoimmune disease that is characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease, and serum autoantibodies to aminoacyl transfer RNA synthetases."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0080744"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080744",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080744",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P01825-1",
            "uniprot_ac": "P01825",
            "uniprot_id": "HV459_HUMAN",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Immunoglobulin heavy variable 4-59",
                    "type": "recommended"
                },
                {
                    "name": "Ig heavy chain V-II region NEWM",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IGHV4-59",
                    "type": "recommended"
                }
            ],
            "record_id": "P01825-1",
            "evidence": [
                {
                    "id": "40607430",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [
        {
            "biomarker_id": "BB3843-1",
            "biomarker_canonical_id": "BB3843",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Immunoglobulin heavy variable 4-59",
                        "synonyms": [
                            {
                                "synonym": "Ig heavy chain V-II region NEWM"
                            }
                        ]
                    },
                    "biomarker": "increased level of fucosylated N-glycan on immunoglobulin G",
                    "assessed_biomarker_entity_id": "P01825-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40607430",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3844-1",
            "biomarker_canonical_id": "BB3844",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Immunoglobulin heavy variable 4-59",
                        "synonyms": [
                            {
                                "synonym": "Ig heavy chain V-II region NEWM"
                            }
                        ]
                    },
                    "biomarker": "decreased level of N-acetylneuraminic acid on immunoglobulin G",
                    "assessed_biomarker_entity_id": "P01825-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40607430",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3845-1",
            "biomarker_canonical_id": "BB3845",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Immunoglobulin heavy variable 4-59",
                        "synonyms": [
                            {
                                "synonym": "Ig heavy chain V-II region NEWM"
                            }
                        ]
                    },
                    "biomarker": "decreased level of sialylated IgG on immunoglobulin G",
                    "assessed_biomarker_entity_id": "P01825-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40607430",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        }
    ],
    "association_flag": "1010",
    "record_id": "doid.0080744"
}