{
    "disease_id": "DOID:0080411",
    "recommended_name": {
        "id": "DOID:0080411",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080411",
        "name": "familial adenomatous polyposis 3",
        "description": "A familial adenomatous polyposis that has_material_basis_in homozygous or compound heterozygous mutation in the NTHL1 gene on chromosome 16p13."
    },
    "synonyms": [
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "familial adenomatous polyposis 3",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "FAP3",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "NTHL1-related AFAP",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "NTHL1-related attenuated FAP",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "NTHL1-related attenuated familial adenomatous polyposis",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "familial adenomatous polyposis 3",
            "description": ""
        },
        {
            "id": "MONDO:0014630",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "name": "familial adenomatous polyposis type 3",
            "description": ""
        },
        {
            "id": "MIM:616415",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/616415",
            "name": "Familial adenomatous polyposis 3",
            "description": "Familial adenomatous polyposis 3"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080411"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080411",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080411",
            "categories": []
        },
        {
            "id": "MONDO:0014630",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014630",
            "categories": []
        },
        {
            "id": "MIM:616415",
            "database": "MIM",
            "url": "https://www.omim.org/entry/616415",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1QBP9-1",
            "uniprot_ac": "F1QBP9",
            "uniprot_id": "F1QBP9_DANRE",
            "refseq_ac": "XP_001346643",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III-like protein 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease III-like protein 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "nthl1",
                    "type": "recommended"
                },
                {
                    "name": "NTHL1",
                    "type": "synonym"
                },
                {
                    "name": "nthl1",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QBP9-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35980-1",
            "uniprot_ac": "O35980",
            "uniprot_id": "NTH_MOUSE",
            "refseq_ac": "NP_032769",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III-like protein 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycoslyase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease III-like protein 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease III-like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "thymine glycol DNA glycosylase/AP lyase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nthl1",
                    "type": "recommended"
                },
                {
                    "name": "Nth1",
                    "type": "synonym"
                },
                {
                    "name": "Nthl1",
                    "type": "synonym"
                },
                {
                    "name": "Octs3",
                    "type": "synonym"
                }
            ],
            "record_id": "O35980-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P78549-2",
            "uniprot_ac": "P78549",
            "uniprot_id": "NTH_HUMAN",
            "refseq_ac": "NP_001305123",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III-like protein 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycoslyase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease III-like protein 1 isoform 3",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease III-like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "hNTH1",
                    "type": "synonym"
                },
                {
                    "name": "nth endonuclease III-like 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NTHL1",
                    "type": "recommended"
                },
                {
                    "name": "FAP3",
                    "type": "synonym"
                },
                {
                    "name": "NTH1",
                    "type": "synonym"
                },
                {
                    "name": "NTHL1",
                    "type": "synonym"
                },
                {
                    "name": "OCTS3",
                    "type": "synonym"
                },
                {
                    "name": "hNTH1",
                    "type": "synonym"
                }
            ],
            "record_id": "P78549-2",
            "evidence": [
                {
                    "id": "616415",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/616415"
                },
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q08214-1",
            "uniprot_ac": "Q08214",
            "uniprot_id": "NTH2_YEAST",
            "refseq_ac": "NP_014599",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III homolog 2",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase 2",
                    "type": "synonym"
                },
                {
                    "name": "Endonuclease III-like glycosylase 2",
                    "type": "synonym"
                },
                {
                    "name": "Redoxyendonuclease 2",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional N-glycosylase/AP lyase NTG2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NTG2",
                    "type": "recommended"
                },
                {
                    "name": "NTG2",
                    "type": "synonym"
                },
                {
                    "name": "SCR2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q08214-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P31378-1",
            "uniprot_ac": "P31378",
            "uniprot_id": "NTH1_YEAST",
            "refseq_ac": "NP_009387",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III homolog 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase 1",
                    "type": "synonym"
                },
                {
                    "name": "Endonuclease III-like glycosylase 1",
                    "type": "synonym"
                },
                {
                    "name": "Redoxyendonuclease 1",
                    "type": "synonym"
                },
                {
                    "name": "bifunctional N-glycosylase/AP lyase NTG1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NTG1",
                    "type": "recommended"
                },
                {
                    "name": "FUN33",
                    "type": "synonym"
                },
                {
                    "name": "NTG1",
                    "type": "synonym"
                },
                {
                    "name": "OGG2",
                    "type": "synonym"
                },
                {
                    "name": "SCR1",
                    "type": "synonym"
                },
                {
                    "name": "ogg2",
                    "type": "synonym"
                }
            ],
            "record_id": "P31378-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D4A4E8-1",
            "uniprot_ac": "D4A4E8",
            "uniprot_id": "D4A4E8_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III-like protein 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nthl1",
                    "type": "recommended"
                },
                {
                    "name": "NTHL1",
                    "type": "synonym"
                }
            ],
            "record_id": "D4A4E8-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VIH0-1",
            "uniprot_ac": "Q9VIH0",
            "uniprot_id": "Q9VIH0_DROME",
            "refseq_ac": "NP_610078",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease III homolog",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase",
                    "type": "synonym"
                },
                {
                    "name": "CG9272-PA",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase",
                    "type": "synonym"
                },
                {
                    "name": "Nth-like DNA glycosylase 1",
                    "type": "synonym"
                },
                {
                    "name": "Nthl1-PA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nthl1",
                    "type": "recommended"
                },
                {
                    "name": "9272",
                    "type": "synonym"
                },
                {
                    "name": "CG9272",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9272",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG9272",
                    "type": "synonym"
                },
                {
                    "name": "NTH1",
                    "type": "synonym"
                },
                {
                    "name": "NTHL1",
                    "type": "synonym"
                },
                {
                    "name": "Nth1",
                    "type": "synonym"
                },
                {
                    "name": "Nthl1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VIH0-1",
            "evidence": [
                {
                    "id": "0080411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080411"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080411"
}