{
    "disease_id": "DOID:0070486",
    "recommended_name": {
        "id": "DOID:0070486",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070486",
        "name": "Parkinson's disease 25",
        "description": "An early-onset Parkinson's disease characterized by mild to moderately impaired intellectual development that has_material_basis_in homozygous or compound heterozygous mutation in the PTPA gene on chromosome 9q34.11."
    },
    "synonyms": [
        {
            "id": "DOID:0070486",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070486",
            "name": "autosomal recessive early-onset Parkinson disease 25 with impaired intellectual development",
            "description": ""
        },
        {
            "id": "DOID:0070486",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070486",
            "name": "PARK25",
            "description": ""
        },
        {
            "id": "MONDO:0957576",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0957576",
            "name": "Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development",
            "description": ""
        },
        {
            "id": "MIM:620482",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/620482",
            "name": "Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development",
            "description": "Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070486"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070486",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070486",
            "categories": []
        },
        {
            "id": "MONDO:0957576",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0957576",
            "categories": []
        },
        {
            "id": "MIM:620482",
            "database": "MIM",
            "url": "https://www.omim.org/entry/620482",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A2CF49-1",
            "uniprot_ac": "A2CF49",
            "uniprot_id": "A2CF49_DANRE",
            "refseq_ac": "NP_001003425",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serine/threonine-protein phosphatase 2A activator",
                    "type": "recommended"
                },
                {
                    "name": "5.2.1.8",
                    "type": "synonym"
                },
                {
                    "name": "Phosphotyrosyl phosphatase activator",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 2A activator, regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A activator",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ptpa",
                    "type": "recommended"
                },
                {
                    "name": "fc23d07",
                    "type": "synonym"
                },
                {
                    "name": "ppp2r4",
                    "type": "synonym"
                },
                {
                    "name": "ptpa",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc23d07",
                    "type": "synonym"
                },
                {
                    "name": "zgc:92766",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0070486",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070486"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P58389-1",
            "uniprot_ac": "P58389",
            "uniprot_id": "PTPA_MOUSE",
            "refseq_ac": "NP_620087",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Serine/threonine-protein phosphatase 2A activator",
                    "type": "recommended"
                },
                {
                    "name": "5.2.1.8",
                    "type": "synonym"
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                {
                    "name": "PP2A, subunit B', PR53 isoform",
                    "type": "synonym"
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                {
                    "name": "Phosphotyrosyl phosphatase activator",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein phosphatase 2A regulatory subunit 4",
                    "type": "synonym"
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                {
                    "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'",
                    "type": "synonym"
                },
                {
                    "name": "phosphotyrosyl phosphatase activator",
                    "type": "synonym"
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                {
                    "name": "protein phosphatase 2A activator, regulatory subunit B",
                    "type": "synonym"
                },
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                    "name": "protein phosphatase 2A, regulatory subunit B (PR 53)",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A activator isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A activator",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A regulatory subunit B'",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ptpa",
                    "type": "recommended"
                },
                {
                    "name": "2610042B21Rik",
                    "type": "synonym"
                },
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                    "name": "PR53",
                    "type": "synonym"
                },
                {
                    "name": "Ppp2r4",
                    "type": "synonym"
                },
                {
                    "name": "Ptpa",
                    "type": "synonym"
                }
            ],
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                }
            ]
        },
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            "uniprot_canonical_ac": "Q15257-1",
            "uniprot_ac": "Q15257",
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            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Serine/threonine-protein phosphatase 2A activator",
                    "type": "recommended"
                },
                {
                    "name": "5.2.1.8",
                    "type": "synonym"
                },
                {
                    "name": "PP2A phosphatase activator",
                    "type": "synonym"
                },
                {
                    "name": "PP2A, subunit B', PR53 isoform",
                    "type": "synonym"
                },
                {
                    "name": "PTPA",
                    "type": "synonym"
                },
                {
                    "name": "Phosphotyrosyl phosphatase activator",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein phosphatase 2A regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'",
                    "type": "synonym"
                },
                {
                    "name": "phosphotyrosyl phosphatase activator",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 2 regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 2A activator, regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 2A regulatory subunit 4",
                    "type": "synonym"
                },
                {
                    "name": "protein phosphatase 2A, regulatory subunit B' (PR 53)",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A activator isoform f",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein phosphatase 2A regulatory subunit B'",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PTPA",
                    "type": "recommended"
                },
                {
                    "name": "PARK25",
                    "type": "synonym"
                },
                {
                    "name": "PP2A",
                    "type": "synonym"
                },
                {
                    "name": "PPP2R4",
                    "type": "synonym"
                },
                {
                    "name": "PR53",
                    "type": "synonym"
                },
                {
                    "name": "PTPA",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "620482",
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                },
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                    "id": "0070486",
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                }
            ]
        },
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            "uniprot_canonical_ac": "Q12461-1",
            "uniprot_ac": "Q12461",
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            "glycoprotein": "no",
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                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
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                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
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                {
                    "name": "Serine/threonine-protein phosphatase 2A activator 2",
                    "type": "recommended"
                },
                {
                    "name": "5.2.1.8",
                    "type": "synonym"
                },
                {
                    "name": "PPIase PTPA-2",
                    "type": "synonym"
                },
                {
                    "name": "Peptidyl-prolyl cis-trans isomerase PTPA-2",
                    "type": "synonym"
                },
                {
                    "name": "Phosphotyrosyl phosphatase activator 2",
                    "type": "synonym"
                },
                {
                    "name": "Rotamase PTPA-2",
                    "type": "synonym"
                },
                {
                    "name": "peptidylprolyl isomerase RRD2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RRD2",
                    "type": "recommended"
                },
                {
                    "name": "NOH1",
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                },
                {
                    "name": "RRD2",
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            ],
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                    "id": "0070486",
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                }
            ]
        },
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            "uniprot_canonical_ac": "P40454-1",
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                }
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                    "name": "Phosphotyrosyl phosphatase activator 1",
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                    "id": "0070486",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
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                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                    "name": "serine/threonine-protein phosphatase 2A activator",
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                    "name": "Ptpa",
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                    "id": "0070486",
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                    "name": "Phosphotyrosyl phosphatase activator",
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                    "name": "Dmel\\CG2104",
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                    "id": "0070486",
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                    "id": "0070486",
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            "uniprot_canonical_ac": "Q9VQQ0-1",
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                    "name": "CG3289-PA",
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                    "name": "PTPA",
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                    "name": "Phosphotyrosyl phosphatase activator",
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                    "id": "0070486",
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                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070486"
}