{
    "disease_id": "DOID:0070185",
    "recommended_name": {
        "id": "DOID:0070185",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070185",
        "name": "X-linked spermatogenic failure 2",
        "description": "A spermatogenic failure that is characterized by meiotic arrest of spermatocytes and mixed testicular atrophy that has_material_basis_in X-linked inheritance of mutation in the TEX11 gene on chromosome Xq13."
    },
    "synonyms": [
        {
            "id": "DOID:0070185",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070185",
            "name": "SPGFX2",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "spermatogenic failure, X-linked, 2",
            "description": "Any azoospermia in which the cause of the disease is a mutation in the TEX11 gene."
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "TEX11 azoospermia",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "azoospermia caused by mutation in TEX11",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "spermatogenic failure, X-linked, 2",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "spermatogenic failure, X-linked, 2, X-linked recessive",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "spermatogenic failure, X-linked, type 2",
            "description": ""
        },
        {
            "id": "MONDO:0010647",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "name": "SPGFX2",
            "description": ""
        },
        {
            "id": "MIM:309120",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/309120",
            "name": "Spermatogenic failure, X-linked, 2",
            "description": "Spermatogenic failure, X-linked, 2"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070185"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070185",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070185",
            "categories": []
        },
        {
            "id": "MONDO:0010647",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010647",
            "categories": []
        },
        {
            "id": "MIM:309120",
            "database": "MIM",
            "url": "https://www.omim.org/entry/309120",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q14AT2-1",
            "uniprot_ac": "Q14AT2",
            "uniprot_id": "TEX11_MOUSE",
            "refseq_ac": "NP_001161469",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Testis-expressed protein 11",
                    "type": "recommended"
                },
                {
                    "name": "Protein ZIP4 homolog",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4H",
                    "type": "synonym"
                },
                {
                    "name": "protein ZIP4 homolog",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed protein 11 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed protein 11",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed sequence 11 protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tex11",
                    "type": "recommended"
                },
                {
                    "name": "4930565P14Rik",
                    "type": "synonym"
                },
                {
                    "name": "Tex11",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4H",
                    "type": "synonym"
                },
                {
                    "name": "Zip4",
                    "type": "synonym"
                }
            ],
            "record_id": "Q14AT2-1",
            "evidence": [
                {
                    "id": "0070185",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070185"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8IYF3-1",
            "uniprot_ac": "Q8IYF3",
            "uniprot_id": "TEX11_HUMAN",
            "refseq_ac": "NP_001003811",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Testis-expressed protein 11",
                    "type": "recommended"
                },
                {
                    "name": "Protein ZIP4 homolog",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4H",
                    "type": "synonym"
                },
                {
                    "name": "protein ZIP4 homolog",
                    "type": "synonym"
                },
                {
                    "name": "testis expressed sequence 11",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed protein 11 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed protein 11",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed sequence 11 protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TEX11",
                    "type": "recommended"
                },
                {
                    "name": "MZIP4",
                    "type": "synonym"
                },
                {
                    "name": "SPGFX2",
                    "type": "synonym"
                },
                {
                    "name": "Spo22",
                    "type": "synonym"
                },
                {
                    "name": "TEX11",
                    "type": "synonym"
                },
                {
                    "name": "TGC1",
                    "type": "synonym"
                },
                {
                    "name": "TSGA3",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4H",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8IYF3-1",
            "evidence": [
                {
                    "id": "309120",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/309120"
                },
                {
                    "id": "0070185",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070185"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P40511-1",
            "uniprot_ac": "P40511",
            "uniprot_id": "SPO22_YEAST",
            "refseq_ac": "NP_012192",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Sporulation-specific protein 22",
                    "type": "recommended"
                },
                {
                    "name": "Spo22p",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SPO22",
                    "type": "recommended"
                },
                {
                    "name": "SPO22",
                    "type": "synonym"
                },
                {
                    "name": "ZIP4",
                    "type": "synonym"
                }
            ],
            "record_id": "P40511-1",
            "evidence": [
                {
                    "id": "0070185",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070185"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D3Z868-1",
            "uniprot_ac": "D3Z868",
            "uniprot_id": "D3Z868_RAT",
            "refseq_ac": "NP_001420274",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein ZIP4 homolog",
                    "type": "recommended"
                },
                {
                    "name": "testis expressed gene 11",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed protein 11",
                    "type": "synonym"
                },
                {
                    "name": "testis-expressed sequence 11 protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tex11",
                    "type": "recommended"
                },
                {
                    "name": "RGD1560239",
                    "type": "synonym"
                },
                {
                    "name": "Tex11",
                    "type": "synonym"
                }
            ],
            "record_id": "D3Z868-1",
            "evidence": [
                {
                    "id": "0070185",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070185"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070185"
}