{
    "disease_id": "DOID:0070183",
    "recommended_name": {
        "id": "DOID:0070183",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070183",
        "name": "spermatogenic failure 5",
        "description": "A spermatogenic failure that is characterized by autosomal recessive inheritance of large-headed, multiflagellar, polyploid spermatozoa that has_material_basis_in mutation in the AURKC gene on chromosome 19q13."
    },
    "synonyms": [
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "male infertility with large-headed, multiflagellar, polyploid spermatozoa",
            "description": ""
        },
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "SPGF5",
            "description": ""
        },
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "macrocephalic sperm head syndrome",
            "description": ""
        },
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "male infertility due to macrozoospermia",
            "description": ""
        },
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "infertility associated with multitailed spermatozoa and excessive DNA",
            "description": ""
        },
        {
            "id": "DOID:0070183",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "name": "Infertility associated with multi-tailed spermatozoa and excessive deoxyribonucleic acid",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "spermatogenic failure 5",
            "description": "A male infertility due to sperm disorder characterized by the presence, in sperm, of a very high percentage of spermatozoa with enlarged head, irregular head shape, multiple flagella, and abnormal midpiece and acrosome. It is generally associated with severe oligoasthenozoospermia and a high rate of sperm chromosomal abnormalities (polyploidy, aneuploidy)."
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "SPGF5",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "macrocephalic sperm head syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "macrozoospermia with multiflagellar polyploid spermatozoa",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "male infertility due to large-headed multiflagellar polyploid spermatozoa",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "male infertility due to macrozoospermia",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "male infertility with large-headed, multiflagellar, polyploid spermatozoa",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "spermatogenic failure 5",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "spermatogenic failure type 5",
            "description": ""
        },
        {
            "id": "MONDO:0009461",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "name": "macrozoospermia",
            "description": ""
        },
        {
            "id": "MIM:243060",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/243060",
            "name": "Spermatogenic failure 5",
            "description": "Spermatogenic failure 5"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070183"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070183",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070183",
            "categories": []
        },
        {
            "id": "MONDO:0009461",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0009461",
            "categories": []
        },
        {
            "id": "MIM:243060",
            "database": "MIM",
            "url": "https://www.omim.org/entry/243060",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q6NW76-1",
            "uniprot_ac": "Q6NW76",
            "uniprot_id": "AURKB_DANRE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Aurora kinase B",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine kinase A",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase 12",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase aurora-B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "aurkb",
                    "type": "recommended"
                },
                {
                    "name": "CHUNP6896",
                    "type": "synonym"
                },
                {
                    "name": "aurB",
                    "type": "synonym"
                },
                {
                    "name": "cei",
                    "type": "synonym"
                },
                {
                    "name": "fa09g06",
                    "type": "synonym"
                },
                {
                    "name": "fd02h12",
                    "type": "synonym"
                },
                {
                    "name": "stka",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa09g06",
                    "type": "synonym"
                },
                {
                    "name": "wu:fd02h12",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6NW76-1",
            "evidence": [
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O88445-1",
            "uniprot_ac": "O88445",
            "uniprot_id": "AURKC_MOUSE",
            "refseq_ac": "NP_001074435",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Aurora kinase C",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "ARK-3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora/IPL1-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora/IPL1/Eg2 protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase 13",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase aurora-C",
                    "type": "synonym"
                },
                {
                    "name": "aurora 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora B",
                    "type": "synonym"
                },
                {
                    "name": "aurora kinase C",
                    "type": "synonym"
                },
                {
                    "name": "aurora-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora/IPL1-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora/Ipl1/Eg2 protein 1",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine kinase 13 (aurora/IPL-like)",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase 13",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase aurora-C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Aurkc",
                    "type": "recommended"
                },
                {
                    "name": "AIE1",
                    "type": "synonym"
                },
                {
                    "name": "AIK3",
                    "type": "synonym"
                },
                {
                    "name": "ARK-3",
                    "type": "synonym"
                },
                {
                    "name": "Aie1",
                    "type": "synonym"
                },
                {
                    "name": "Aik3",
                    "type": "synonym"
                },
                {
                    "name": "Airk3",
                    "type": "synonym"
                },
                {
                    "name": "Ark3",
                    "type": "synonym"
                },
                {
                    "name": "Aurkc",
                    "type": "synonym"
                },
                {
                    "name": "IAK3",
                    "type": "synonym"
                },
                {
                    "name": "Stk13",
                    "type": "synonym"
                }
            ],
            "record_id": "O88445-1",
            "evidence": [
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9UQB9-1",
            "uniprot_ac": "Q9UQB9",
            "uniprot_id": "AURKC_HUMAN",
            "refseq_ac": "NP_001015878",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Aurora kinase C",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "ARK-3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora/IPL1-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "Aurora/IPL1/Eg2 protein 2",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase 13",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase aurora-C",
                    "type": "synonym"
                },
                {
                    "name": "aurora 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora kinase C isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "aurora-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora/IPL1-related kinase 3",
                    "type": "synonym"
                },
                {
                    "name": "aurora/IPL1/EG2 protein 2",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory protein Li 90",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine kinase 13 (aurora/IPL1-like)",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase 13",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase aurora-C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "AURKC",
                    "type": "recommended"
                },
                {
                    "name": "AIE2",
                    "type": "synonym"
                },
                {
                    "name": "AIK3",
                    "type": "synonym"
                },
                {
                    "name": "AIRK3",
                    "type": "synonym"
                },
                {
                    "name": "ARK3",
                    "type": "synonym"
                },
                {
                    "name": "AURKC",
                    "type": "synonym"
                },
                {
                    "name": "AurC",
                    "type": "synonym"
                },
                {
                    "name": "HEL-S-90",
                    "type": "synonym"
                },
                {
                    "name": "SPGF5",
                    "type": "synonym"
                },
                {
                    "name": "STK13",
                    "type": "synonym"
                },
                {
                    "name": "aurora-C",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9UQB9-1",
            "evidence": [
                {
                    "id": "243060",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/243060"
                },
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P38991-1",
            "uniprot_ac": "P38991",
            "uniprot_id": "AURK_YEAST",
            "refseq_ac": "NP_015115",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Aurora kinase",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "Increase-in-ploidy protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Spindle assembly checkpoint kinase",
                    "type": "synonym"
                },
                {
                    "name": "aurora kinase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IPL1",
                    "type": "recommended"
                },
                {
                    "name": "IPL1",
                    "type": "synonym"
                },
                {
                    "name": "PAC15",
                    "type": "synonym"
                }
            ],
            "record_id": "P38991-1",
            "evidence": [
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D4AD76-1",
            "uniprot_ac": "D4AD76",
            "uniprot_id": "D4AD76_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "non-specific serine/threonine protein kinase",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Aurkc",
                    "type": "recommended"
                }
            ],
            "record_id": "D4AD76-1",
            "evidence": [
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VGF9-1",
            "uniprot_ac": "Q9VGF9",
            "uniprot_id": "Q9VGF9_DROME",
            "refseq_ac": "NP_476749",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Aurora kinase",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "A-type aurora kinase",
                    "type": "synonym"
                },
                {
                    "name": "Aurora-A kinase",
                    "type": "synonym"
                },
                {
                    "name": "AuroraA",
                    "type": "synonym"
                },
                {
                    "name": "CG3068-PA",
                    "type": "synonym"
                },
                {
                    "name": "aurA-PA",
                    "type": "synonym"
                },
                {
                    "name": "aurka",
                    "type": "synonym"
                },
                {
                    "name": "aurora A kinase",
                    "type": "synonym"
                },
                {
                    "name": "aurora A",
                    "type": "synonym"
                },
                {
                    "name": "aurora-A",
                    "type": "synonym"
                },
                {
                    "name": "early-A",
                    "type": "synonym"
                },
                {
                    "name": "fruhe2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "aurA",
                    "type": "recommended"
                },
                {
                    "name": "2",
                    "type": "synonym"
                },
                {
                    "name": "87A7-9/2",
                    "type": "synonym"
                },
                {
                    "name": "AAK",
                    "type": "synonym"
                },
                {
                    "name": "AURKA",
                    "type": "synonym"
                },
                {
                    "name": "AUR",
                    "type": "synonym"
                },
                {
                    "name": "Aur-A",
                    "type": "synonym"
                },
                {
                    "name": "AurA",
                    "type": "synonym"
                },
                {
                    "name": "Aurora A",
                    "type": "synonym"
                },
                {
                    "name": "Aur",
                    "type": "synonym"
                },
                {
                    "name": "CG3068",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG3068",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG3068",
                    "type": "synonym"
                },
                {
                    "name": "aur-A",
                    "type": "synonym"
                },
                {
                    "name": "aurA",
                    "type": "synonym"
                },
                {
                    "name": "aurka",
                    "type": "synonym"
                },
                {
                    "name": "aur",
                    "type": "synonym"
                },
                {
                    "name": "ck10",
                    "type": "synonym"
                },
                {
                    "name": "ck[10]",
                    "type": "synonym"
                },
                {
                    "name": "l(3)87Ac",
                    "type": "synonym"
                },
                {
                    "name": "l(3)ck10",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VGF9-1",
            "evidence": [
                {
                    "id": "0070183",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070183"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070183"
}