{
    "disease_id": "DOID:0070177",
    "recommended_name": {
        "id": "DOID:0070177",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070177",
        "name": "spermatogenic failure 22",
        "description": "A spermatogenic failure that is characterized by autosomal recessive inheritance of spermatocyte maturation arrest resulting in azoospermia that has_material_basis_in mutation in the MEIOB gene on chromosome 16p13."
    },
    "synonyms": [
        {
            "id": "DOID:0070177",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070177",
            "name": "SPGF22",
            "description": ""
        },
        {
            "id": "MONDO:0054726",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0054726",
            "name": "spermatogenic failure 22",
            "description": ""
        },
        {
            "id": "MONDO:0054726",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0054726",
            "name": "spermatogenic failure 22",
            "description": ""
        },
        {
            "id": "MONDO:0054726",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0054726",
            "name": "SPGF22",
            "description": ""
        },
        {
            "id": "MIM:617706",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/617706",
            "name": "Spermatogenic failure 22",
            "description": "Spermatogenic failure 22"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070177"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070177",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070177",
            "categories": []
        },
        {
            "id": "MONDO:0054726",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0054726",
            "categories": []
        },
        {
            "id": "MIM:617706",
            "database": "MIM",
            "url": "https://www.omim.org/entry/617706",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A2R8RX28-1",
            "uniprot_ac": "A0A2R8RX28",
            "uniprot_id": "A0A2R8RX28_DANRE",
            "refseq_ac": "XP_068074771",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Meiosis-specific with OB domain-containing protein isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "meiosis-specific with OB domain-containing protein isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "meiob",
                    "type": "recommended"
                },
                {
                    "name": "meiob",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A2R8RX28-1",
            "evidence": [
                {
                    "id": "0070177",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070177"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9D513-1",
            "uniprot_ac": "Q9D513",
            "uniprot_id": "MEIOB_MOUSE",
            "refseq_ac": "NP_083473",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Meiosis-specific with OB domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "3.1.-.-",
                    "type": "synonym"
                },
                {
                    "name": "MLZ-675",
                    "type": "synonym"
                },
                {
                    "name": "Protein expressed in male leptotene and zygotene spermatocytes 675",
                    "type": "synonym"
                },
                {
                    "name": "meiosis-specific with OB domain-containing protein",
                    "type": "synonym"
                },
                {
                    "name": "protein expressed in male leptotene and zygotene spermatocytes 675",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Meiob",
                    "type": "recommended"
                },
                {
                    "name": "4930528F23Rik",
                    "type": "synonym"
                },
                {
                    "name": "MLZ-675",
                    "type": "synonym"
                },
                {
                    "name": "Meiob",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9D513-1",
            "evidence": [
                {
                    "id": "0070177",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070177"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8N635-1",
            "uniprot_ac": "Q8N635",
            "uniprot_id": "MEIOB_HUMAN",
            "refseq_ac": "NP_001157032",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Meiosis-specific with OB domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "3.1.-.-",
                    "type": "synonym"
                },
                {
                    "name": "meiosis specific with OB domains",
                    "type": "synonym"
                },
                {
                    "name": "meiosis-specific with OB domain-containing protein isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "meiosis-specific with OB domain-containing protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MEIOB",
                    "type": "recommended"
                },
                {
                    "name": "C16orf73",
                    "type": "synonym"
                },
                {
                    "name": "MEIOB",
                    "type": "synonym"
                },
                {
                    "name": "POF23",
                    "type": "synonym"
                },
                {
                    "name": "SPGF22",
                    "type": "synonym"
                },
                {
                    "name": "gs129",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8N635-1",
            "evidence": [
                {
                    "id": "617706",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/617706"
                },
                {
                    "id": "0070177",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070177"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "B0BMX9-1",
            "uniprot_ac": "B0BMX9",
            "uniprot_id": "MEIOB_RAT",
            "refseq_ac": "NP_001108505",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Meiosis-specific with OB domain-containing protein",
                    "type": "recommended"
                },
                {
                    "name": "3.1.-.-",
                    "type": "synonym"
                },
                {
                    "name": "meiosis specific with OB domains",
                    "type": "synonym"
                },
                {
                    "name": "meiosis-specific with OB domain-containing protein",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein C16orf73 homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Meiob",
                    "type": "recommended"
                },
                {
                    "name": "Meiob",
                    "type": "synonym"
                }
            ],
            "record_id": "B0BMX9-1",
            "evidence": [
                {
                    "id": "0070177",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070177"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9W3M9-1",
            "uniprot_ac": "Q9W3M9",
            "uniprot_id": "HDM_DROME",
            "refseq_ac": "NP_572422",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein hold'em",
                    "type": "recommended"
                },
                {
                    "name": "CG15329-PA",
                    "type": "synonym"
                },
                {
                    "name": "hdm-PA",
                    "type": "synonym"
                },
                {
                    "name": "hold'em",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "hdm",
                    "type": "recommended"
                },
                {
                    "name": "CG15329",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG15329",
                    "type": "synonym"
                },
                {
                    "name": "HDM",
                    "type": "synonym"
                },
                {
                    "name": "Hdm",
                    "type": "synonym"
                },
                {
                    "name": "hdm",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9W3M9-1",
            "evidence": [
                {
                    "id": "0070177",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070177"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070177"
}