{
    "disease_id": "DOID:0070176",
    "recommended_name": {
        "id": "DOID:0070176",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070176",
        "name": "spermatogenic failure 4",
        "description": "A spermatogenic failure that is characterized by autosomal dominant inheritance of nonobstructive azoospermia caused by meiotic abnormalities that has_material_basis_in mutation in the SYCP3 gene on chromosome 12q23."
    },
    "synonyms": [
        {
            "id": "DOID:0070176",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070176",
            "name": "SPGF4",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "spermatogenic failure 4",
            "description": "Any azoospermia in which the cause of the disease is a mutation in the SYCP3 gene."
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "SYCP3 azoospermia",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "azoospermia caused by mutation in SYCP3",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "spermatogenic failure 4",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "spermatogenic failure type 4",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "SPGF4",
            "description": ""
        },
        {
            "id": "MONDO:0010052",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "name": "arrest of spermatogenesis",
            "description": ""
        },
        {
            "id": "MIM:270960",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/270960",
            "name": "Spermatogenic failure 4",
            "description": "Spermatogenic failure 4"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070176"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070176",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070176",
            "categories": []
        },
        {
            "id": "MONDO:0010052",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010052",
            "categories": []
        },
        {
            "id": "MIM:270960",
            "database": "MIM",
            "url": "https://www.omim.org/entry/270960",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A087WRF5-1",
            "uniprot_ac": "A0A087WRF5",
            "uniprot_id": "A0A087WRF5_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene 28891",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 20792",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 20837",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 20838",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21094",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21256",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21739",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21861",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 57478",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm20792",
                    "type": "recommended"
                },
                {
                    "name": "Gm21739",
                    "type": "recommended"
                },
                {
                    "name": "Gm20792",
                    "type": "synonym"
                },
                {
                    "name": "Gm20837",
                    "type": "synonym"
                },
                {
                    "name": "Gm20838",
                    "type": "synonym"
                },
                {
                    "name": "Gm21094",
                    "type": "synonym"
                },
                {
                    "name": "Gm21256",
                    "type": "synonym"
                },
                {
                    "name": "Gm21739",
                    "type": "synonym"
                },
                {
                    "name": "Gm21861",
                    "type": "synonym"
                },
                {
                    "name": "Gm28891",
                    "type": "synonym"
                },
                {
                    "name": "Gm57478",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WRF5-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A087WQC7-1",
            "uniprot_ac": "A0A087WQC7",
            "uniprot_id": "A0A087WQC7_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 20736",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21258",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm20736",
                    "type": "recommended"
                },
                {
                    "name": "Gm21258",
                    "type": "recommended"
                },
                {
                    "name": "Gm20736",
                    "type": "synonym"
                },
                {
                    "name": "Gm21258",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WQC7-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A087WP44-1",
            "uniprot_ac": "A0A087WP44",
            "uniprot_id": "A0A087WP44_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene 28827",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene 28897",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene 29110",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene 29564",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21760",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 31571",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm29564",
                    "type": "recommended"
                },
                {
                    "name": "Gm31571",
                    "type": "recommended"
                },
                {
                    "name": "Gm21760",
                    "type": "synonym"
                },
                {
                    "name": "Gm28827",
                    "type": "synonym"
                },
                {
                    "name": "Gm28897",
                    "type": "synonym"
                },
                {
                    "name": "Gm29110",
                    "type": "synonym"
                },
                {
                    "name": "Gm29564",
                    "type": "synonym"
                },
                {
                    "name": "Gm31571",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WP44-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A087WS79-1",
            "uniprot_ac": "A0A087WS79",
            "uniprot_id": "A0A087WS79_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 21294",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm21294",
                    "type": "recommended"
                }
            ],
            "record_id": "A0A087WS79-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P05531-1",
            "uniprot_ac": "P05531",
            "uniprot_id": "XLR_MOUSE",
            "refseq_ac": "NP_001278676",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "X-linked lymphocyte-regulated protein PM1",
                    "type": "recommended"
                },
                {
                    "name": "X-linked gene family of B-cell surface antigens",
                    "type": "synonym"
                },
                {
                    "name": "X-linked lymphocyte-regulated complex",
                    "type": "synonym"
                },
                {
                    "name": "X-linked lymphocyte-regulated protein PM1 isoform a",
                    "type": "synonym"
                },
                {
                    "name": "X-linked lymphocyte-regulated protein pM1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Xlr",
                    "type": "recommended"
                },
                {
                    "name": "Xlr",
                    "type": "synonym"
                }
            ],
            "record_id": "P05531-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A087WPP3-1",
            "uniprot_ac": "A0A087WPP3",
            "uniprot_id": "A0A087WPP3_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 20820",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm20820",
                    "type": "recommended"
                }
            ],
            "record_id": "A0A087WPP3-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A087WRL2-1",
            "uniprot_ac": "A0A087WRL2",
            "uniprot_id": "A0A087WRL2_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 21865",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 30737",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 35134",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm21865",
                    "type": "recommended"
                },
                {
                    "name": "Gm35134",
                    "type": "recommended"
                },
                {
                    "name": "Gm21865",
                    "type": "synonym"
                },
                {
                    "name": "Gm30737",
                    "type": "synonym"
                },
                {
                    "name": "Gm35134",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WRL2-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
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        {
            "uniprot_canonical_ac": "A0A087WRP6-1",
            "uniprot_ac": "A0A087WRP6",
            "uniprot_id": "A0A087WRP6_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene 28576",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene 28998",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm28576",
                    "type": "recommended"
                },
                {
                    "name": "Gm28998",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WRP6-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
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        },
        {
            "uniprot_canonical_ac": "A0A0A6YX04-1",
            "uniprot_ac": "A0A0A6YX04",
            "uniprot_id": "A0A0A6YX04_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 29866",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm29866",
                    "type": "recommended"
                }
            ],
            "record_id": "A0A0A6YX04-1",
            "evidence": [
                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
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            "uniprot_canonical_ac": "A0A087WRK3-1",
            "uniprot_ac": "A0A087WRK3",
            "uniprot_id": "A0A087WRK3_MOUSE",
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            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene 28553",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 20817",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21173",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21497",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm21173",
                    "type": "recommended"
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                {
                    "name": "Gm28553",
                    "type": "recommended"
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                {
                    "name": "Gm20817",
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                {
                    "name": "Gm21173",
                    "type": "synonym"
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                {
                    "name": "Gm21497",
                    "type": "synonym"
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                {
                    "name": "Gm28553",
                    "type": "synonym"
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            ],
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                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
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            "uniprot_canonical_ac": "A0A087WSS0-1",
            "uniprot_ac": "A0A087WSS0",
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            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 20911",
                    "type": "synonym"
                },
                {
                    "name": "X-linked lymphocyte-regulated protein PM1-like",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm20911",
                    "type": "recommended"
                },
                {
                    "name": "Gm20911",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A087WSS0-1",
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                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
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        {
            "uniprot_canonical_ac": "A0A087WRT9-1",
            "uniprot_ac": "A0A087WRT9",
            "uniprot_id": "A0A087WRT9_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Predicted gene 28490",
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                {
                    "name": "Predicted gene 29582",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm29582",
                    "type": "recommended"
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                {
                    "name": "Gm28490",
                    "type": "synonym"
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                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
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            "uniprot_canonical_ac": "A0A087WQA3-1",
            "uniprot_ac": "A0A087WQA3",
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                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
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            ],
            "protein_names": [
                {
                    "name": "Predicted gene, 20843",
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                },
                {
                    "name": "Predicted gene, 20888",
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                },
                {
                    "name": "Predicted gene, 20937",
                    "type": "synonym"
                },
                {
                    "name": "Predicted gene, 21209",
                    "type": "synonym"
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                {
                    "name": "Predicted gene, 21518",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm21209",
                    "type": "recommended"
                },
                {
                    "name": "Gm21518",
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                {
                    "name": "Gm21650",
                    "type": "recommended"
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                {
                    "name": "Gm20843",
                    "type": "synonym"
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                {
                    "name": "Gm20888",
                    "type": "synonym"
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                {
                    "name": "Gm20937",
                    "type": "synonym"
                },
                {
                    "name": "Gm21209",
                    "type": "synonym"
                },
                {
                    "name": "Gm21518",
                    "type": "synonym"
                },
                {
                    "name": "Gm21650",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0070176",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070176"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P70281-1",
            "uniprot_ac": "P70281",
            "uniprot_id": "SYCP3_MOUSE",
            "refseq_ac": "NP_035647",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Synaptonemal complex protein 3",
                    "type": "recommended"
                },
                {
                    "name": "SCP-3",
                    "type": "synonym"
                },
                {
                    "name": "synaptonemal complex protein 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sycp3",
                    "type": "recommended"
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    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
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}