{
    "disease_id": "DOID:0070082",
    "recommended_name": {
        "id": "DOID:0070082",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070082",
        "name": "schizophrenia 6",
        "description": "A schizophrenia that has_material_basis_in an autosomal dominant mutation of the SCZD6 gene on chromosome 8p21."
    },
    "synonyms": [
        {
            "id": "DOID:0070082",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070082",
            "name": "SCZD6",
            "description": ""
        },
        {
            "id": "MONDO:0011280",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011280",
            "name": "schizophrenia 6",
            "description": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21."
        },
        {
            "id": "MONDO:0011280",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011280",
            "name": "SCZD6",
            "description": ""
        },
        {
            "id": "MONDO:0011280",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011280",
            "name": "schizophrenia 6",
            "description": ""
        },
        {
            "id": "MONDO:0011280",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011280",
            "name": "schizophrenia susceptibility locus, chromosome 8P-related",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070082"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070082",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070082",
            "categories": []
        },
        {
            "id": "MONDO:0011280",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011280",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A0R4IBM0-1",
            "uniprot_ac": "A0A0R4IBM0",
            "uniprot_id": "A0A0R4IBM0_DANRE",
            "refseq_ac": "NP_001264015",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pro-neuregulin-1, membrane-bound isoform isoform IIb12",
                    "type": "synonym"
                },
                {
                    "name": "neuregulin 1 type I isoform",
                    "type": "synonym"
                },
                {
                    "name": "neuregulin 1 type II isoform",
                    "type": "synonym"
                },
                {
                    "name": "neuregulin 1 type III isoform",
                    "type": "synonym"
                },
                {
                    "name": "neuregulin1",
                    "type": "synonym"
                },
                {
                    "name": "pro-neuregulin-1, membrane-bound isoform isoform IIb12",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "nrg1",
                    "type": "recommended"
                },
                {
                    "name": "nrg1",
                    "type": "synonym"
                },
                {
                    "name": "wu:fm70e01",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A0R4IBM0-1",
            "evidence": [
                {
                    "id": "0070082",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070082"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6DR98-1",
            "uniprot_ac": "Q6DR98",
            "uniprot_id": "NRG1_MOUSE",
            "refseq_ac": "NP_001351350",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pro-neuregulin-1, membrane-bound isoform",
                    "type": "recommended"
                },
                {
                    "name": "ARIA",
                    "type": "synonym"
                },
                {
                    "name": "Acetylcholine receptor-inducing activity",
                    "type": "synonym"
                },
                {
                    "name": "Glial growth factor",
                    "type": "synonym"
                },
                {
                    "name": "HRG",
                    "type": "synonym"
                },
                {
                    "name": "Heregulin",
                    "type": "synonym"
                },
                {
                    "name": "Neu differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "Pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "Sensory and motor neuron-derived factor",
                    "type": "synonym"
                },
                {
                    "name": "heregulin",
                    "type": "synonym"
                },
                {
                    "name": "pro-neuregulin-1, membrane-bound isoform isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "pro-neuregulin-1, membrane-bound isoform",
                    "type": "synonym"
                },
                {
                    "name": "type I neuregulin 1",
                    "type": "synonym"
                },
                {
                    "name": "type III neuregulin 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nrg1",
                    "type": "recommended"
                },
                {
                    "name": "6030402G23Rik",
                    "type": "synonym"
                },
                {
                    "name": "ARIA",
                    "type": "synonym"
                },
                {
                    "name": "D230005F13Rik",
                    "type": "synonym"
                },
                {
                    "name": "GGFII",
                    "type": "synonym"
                },
                {
                    "name": "GGF",
                    "type": "synonym"
                },
                {
                    "name": "HRGalpha",
                    "type": "synonym"
                },
                {
                    "name": "HRG",
                    "type": "synonym"
                },
                {
                    "name": "Hgl",
                    "type": "synonym"
                },
                {
                    "name": "NDF",
                    "type": "synonym"
                },
                {
                    "name": "Nrg1",
                    "type": "synonym"
                },
                {
                    "name": "Pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "SMDF",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6DR98-1",
            "evidence": [
                {
                    "id": "0070082",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070082"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P43322-1",
            "uniprot_ac": "P43322",
            "uniprot_id": "NRG1_RAT",
            "refseq_ac": "NP_001258052",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pro-neuregulin-1, membrane-bound isoform",
                    "type": "recommended"
                },
                {
                    "name": "ARIA",
                    "type": "synonym"
                },
                {
                    "name": "Acetylcholine receptor-inducing activity",
                    "type": "synonym"
                },
                {
                    "name": "Glial growth factor",
                    "type": "synonym"
                },
                {
                    "name": "HRG",
                    "type": "synonym"
                },
                {
                    "name": "Heregulin",
                    "type": "synonym"
                },
                {
                    "name": "Neu differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "Pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "Sensory and motor neuron-derived factor",
                    "type": "synonym"
                },
                {
                    "name": "glial growth factor",
                    "type": "synonym"
                },
                {
                    "name": "neuregulin 1 type III beta 3",
                    "type": "synonym"
                },
                {
                    "name": "pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "pro-neuregulin-1, membrane-bound isoform isoform 6",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nrg1",
                    "type": "recommended"
                },
                {
                    "name": "Ndf",
                    "type": "synonym"
                },
                {
                    "name": "Nrg1",
                    "type": "synonym"
                }
            ],
            "record_id": "P43322-1",
            "evidence": [
                {
                    "id": "0070082",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070082"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q94918-1",
            "uniprot_ac": "Q94918",
            "uniprot_id": "VEIN_DROME",
            "refseq_ac": "NP_523942",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein vein",
                    "type": "recommended"
                },
                {
                    "name": "CG10491-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dm vein",
                    "type": "synonym"
                },
                {
                    "name": "Epidermal growth factor-like protein",
                    "type": "synonym"
                },
                {
                    "name": "Protein defective dorsal discs",
                    "type": "synonym"
                },
                {
                    "name": "defective dorsal discs",
                    "type": "synonym"
                },
                {
                    "name": "vein, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "vein",
                    "type": "synonym"
                },
                {
                    "name": "vn-PA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "vn",
                    "type": "recommended"
                },
                {
                    "name": "CG10491",
                    "type": "synonym"
                },
                {
                    "name": "CT29452",
                    "type": "synonym"
                },
                {
                    "name": "Dm vn",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG10491",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG10491",
                    "type": "synonym"
                },
                {
                    "name": "P1749",
                    "type": "synonym"
                },
                {
                    "name": "Vein",
                    "type": "synonym"
                },
                {
                    "name": "Vn",
                    "type": "synonym"
                },
                {
                    "name": "ddd",
                    "type": "synonym"
                },
                {
                    "name": "l(3)10567",
                    "type": "synonym"
                },
                {
                    "name": "l(3)10568",
                    "type": "synonym"
                },
                {
                    "name": "l(3)L6A",
                    "type": "synonym"
                },
                {
                    "name": "l(3)ddd",
                    "type": "synonym"
                },
                {
                    "name": "l(3)rF264",
                    "type": "synonym"
                },
                {
                    "name": "l(3)vn10567",
                    "type": "synonym"
                },
                {
                    "name": "vn",
                    "type": "synonym"
                },
                {
                    "name": "wvn",
                    "type": "synonym"
                }
            ],
            "record_id": "Q94918-1",
            "evidence": [
                {
                    "id": "0070082",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070082"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q02297-1",
            "uniprot_ac": "Q02297",
            "uniprot_id": "NRG1_HUMAN",
            "refseq_ac": "NP_001153467",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Pro-neuregulin-1, membrane-bound isoform",
                    "type": "recommended"
                },
                {
                    "name": "ARIA",
                    "type": "synonym"
                },
                {
                    "name": "Acetylcholine receptor-inducing activity",
                    "type": "synonym"
                },
                {
                    "name": "Breast cancer cell differentiation factor p45",
                    "type": "synonym"
                },
                {
                    "name": "Glial growth factor",
                    "type": "synonym"
                },
                {
                    "name": "HRG",
                    "type": "synonym"
                },
                {
                    "name": "Heregulin",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform alpha 2a",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform alpha 2b",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform alpha beta 2a",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform alpha beta 3",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform beta 2a",
                    "type": "synonym"
                },
                {
                    "name": "NRG1 class VII isoform beta 3",
                    "type": "synonym"
                },
                {
                    "name": "Neu differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "Pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "Sensory and motor neuron-derived factor",
                    "type": "synonym"
                },
                {
                    "name": "acetylcholine receptor-inducing activity",
                    "type": "synonym"
                },
                {
                    "name": "glial growth factor 2",
                    "type": "synonym"
                },
                {
                    "name": "heregulin, alpha (45kD, ERBB2 p185-activator)",
                    "type": "synonym"
                },
                {
                    "name": "neu differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "pro-NRG1",
                    "type": "synonym"
                },
                {
                    "name": "pro-neuregulin-1, membrane-bound isoform isoform HRG-beta1c",
                    "type": "synonym"
                },
                {
                    "name": "sensory and motor neuron derived factor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NRG1",
                    "type": "recommended"
                },
                {
                    "name": "ARIA",
                    "type": "synonym"
                },
                {
                    "name": "GGF2",
                    "type": "synonym"
                },
                {
                    "name": "GGF",
                    "type": "synonym"
                },
                {
                    "name": "HGL",
                    "type": "synonym"
                },
                {
                    "name": "HRG1",
                    "type": "synonym"
                },
                {
                    "name": "HRGA",
                    "type": "synonym"
                },
                {
                    "name": "HRG",
                    "type": "synonym"
                },
                {
                    "name": "MST131",
                    "type": "synonym"
                },
                {
                    "name": "MSTP131",
                    "type": "synonym"
                },
                {
                    "name": "NDF",
                    "type": "synonym"
                },
                {
                    "name": "NRG1-IT2",
                    "type": "synonym"
                },
                {
                    "name": "NRG1",
                    "type": "synonym"
                },
                {
                    "name": "SMDF",
                    "type": "synonym"
                }
            ],
            "record_id": "Q02297-1",
            "evidence": [
                {
                    "id": "0070082",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070082"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070082"
}