{
    "disease_id": "DOID:0061085",
    "recommended_name": {
        "id": "DOID:0061085",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0061085",
        "name": "immunodeficiency 119",
        "description": "A T cell, B cell, and NK cell deficiency that is characterized by the onset of recurrent upper and lower respiratory infections and warts in childhood and that has_material_basis_in homozygous mutation in the ICOSLG gene on chromosome 21q22. Affected individuals are susceptible to chronic DNA-based viral infections, including HPV and HSV."
    },
    "synonyms": [
        {
            "id": "MONDO:0970993",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0970993",
            "name": "immunodeficiency 119",
            "description": ""
        },
        {
            "id": "MIM:620825",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/620825",
            "name": "Immunodeficiency 119",
            "description": "Immunodeficiency 119"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0061085"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0061085",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061085",
            "categories": []
        },
        {
            "id": "MONDO:0970993",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0970993",
            "categories": []
        },
        {
            "id": "MIM:620825",
            "database": "MIM",
            "url": "https://www.omim.org/entry/620825",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q9JHJ8-1",
            "uniprot_ac": "Q9JHJ8",
            "uniprot_id": "ICOSL_MOUSE",
            "refseq_ac": "NP_056605",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "ICOS ligand",
                    "type": "recommended"
                },
                {
                    "name": "B7 homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "B7-H2",
                    "type": "synonym"
                },
                {
                    "name": "B7-like protein Gl50",
                    "type": "synonym"
                },
                {
                    "name": "B7-related protein 1",
                    "type": "synonym"
                },
                {
                    "name": "B7RP-1",
                    "type": "synonym"
                },
                {
                    "name": "ICOS ligand precursor",
                    "type": "synonym"
                },
                {
                    "name": "LICOS",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Icoslg",
                    "type": "recommended"
                },
                {
                    "name": "Icosl",
                    "type": "recommended"
                },
                {
                    "name": "B7-H2",
                    "type": "synonym"
                },
                {
                    "name": "B7RP-1",
                    "type": "synonym"
                },
                {
                    "name": "B7h2",
                    "type": "synonym"
                },
                {
                    "name": "B7h",
                    "type": "synonym"
                },
                {
                    "name": "B7rp1",
                    "type": "synonym"
                },
                {
                    "name": "GI50",
                    "type": "synonym"
                },
                {
                    "name": "GL50-B",
                    "type": "synonym"
                },
                {
                    "name": "GL50",
                    "type": "synonym"
                },
                {
                    "name": "ICOS-L",
                    "type": "synonym"
                },
                {
                    "name": "Icoslg",
                    "type": "synonym"
                },
                {
                    "name": "Icosl",
                    "type": "synonym"
                },
                {
                    "name": "LICOS",
                    "type": "synonym"
                },
                {
                    "name": "Ly115l",
                    "type": "synonym"
                },
                {
                    "name": "mKIAA0653",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9JHJ8-1",
            "evidence": [
                {
                    "id": "0061085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O75144-1",
            "uniprot_ac": "O75144",
            "uniprot_id": "ICOSL_HUMAN",
            "refseq_ac": "NP_001269979",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "ICOS ligand",
                    "type": "recommended"
                },
                {
                    "name": "B7 homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "B7 homologue 2",
                    "type": "synonym"
                },
                {
                    "name": "B7-H2",
                    "type": "synonym"
                },
                {
                    "name": "B7-like protein Gl50",
                    "type": "synonym"
                },
                {
                    "name": "B7-related protein 1",
                    "type": "synonym"
                },
                {
                    "name": "B7RP-1",
                    "type": "synonym"
                },
                {
                    "name": "ICOS ligand isoform b precursor",
                    "type": "synonym"
                },
                {
                    "name": "transmembrane protein B7-H2 ICOS ligand",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ICOSLG",
                    "type": "recommended"
                },
                {
                    "name": "B7-H2",
                    "type": "synonym"
                },
                {
                    "name": "B7H2",
                    "type": "synonym"
                },
                {
                    "name": "B7RP-1",
                    "type": "synonym"
                },
                {
                    "name": "B7RP1",
                    "type": "synonym"
                },
                {
                    "name": "B7h",
                    "type": "synonym"
                },
                {
                    "name": "CD275",
                    "type": "synonym"
                },
                {
                    "name": "GL50",
                    "type": "synonym"
                },
                {
                    "name": "ICOS-L",
                    "type": "synonym"
                },
                {
                    "name": "ICOSLG",
                    "type": "synonym"
                },
                {
                    "name": "ICOSL",
                    "type": "synonym"
                },
                {
                    "name": "IMD119",
                    "type": "synonym"
                },
                {
                    "name": "KIAA0653",
                    "type": "synonym"
                },
                {
                    "name": "LICOS",
                    "type": "synonym"
                }
            ],
            "record_id": "O75144-1",
            "evidence": [
                {
                    "id": "620825",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/620825"
                },
                {
                    "id": "0061085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1LVL2-1",
            "uniprot_ac": "F1LVL2",
            "uniprot_id": "F1LVL2_RAT",
            "refseq_ac": "NP_001414305",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "ICOS ligand",
                    "type": "recommended"
                },
                {
                    "name": "B7 homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "B7-like protein Gl50",
                    "type": "synonym"
                },
                {
                    "name": "B7-related protein 1",
                    "type": "synonym"
                },
                {
                    "name": "ICOS ligand isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "icos ligand",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Icoslg",
                    "type": "recommended"
                },
                {
                    "name": "Icoslg",
                    "type": "synonym"
                },
                {
                    "name": "Icosl",
                    "type": "synonym"
                },
                {
                    "name": "RGD1562791",
                    "type": "synonym"
                }
            ],
            "record_id": "F1LVL2-1",
            "evidence": [
                {
                    "id": "0061085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061085"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0061085"
}