{
    "disease_id": "DOID:0061006",
    "recommended_name": {
        "id": "DOID:0061006",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0061006",
        "name": "advanced sleep phase syndrome 4",
        "description": "An advanced sleep phase syndrome that has_material_basis_in heterozygous mutation in the TIMELESS gene on chromosome 12q13."
    },
    "synonyms": [
        {
            "id": "DOID:0061006",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061006",
            "name": "familial advanced sleep phase syndrome 4",
            "description": ""
        },
        {
            "id": "DOID:0061006",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061006",
            "name": "FASPS4",
            "description": ""
        },
        {
            "id": "MONDO:0031044",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0031044",
            "name": "advance sleep phase syndrome, familial, 4",
            "description": ""
        },
        {
            "id": "MONDO:0031044",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0031044",
            "name": "FASPS4",
            "description": ""
        },
        {
            "id": "MONDO:0031044",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0031044",
            "name": "advance sleep phase syndrome, familial, 4",
            "description": ""
        },
        {
            "id": "MIM:620015",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/620015",
            "name": "Advanced sleep phase syndrome, familial, 4",
            "description": "Advanced sleep phase syndrome, familial, 4"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0061006"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0061006",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061006",
            "categories": []
        },
        {
            "id": "MONDO:0031044",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0031044",
            "categories": []
        },
        {
            "id": "MIM:620015",
            "database": "MIM",
            "url": "https://www.omim.org/entry/620015",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "E7FGL0-1",
            "uniprot_ac": "E7FGL0",
            "uniprot_id": "E7FGL0_DANRE",
            "refseq_ac": "NP_001265529",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein timeless homolog",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog",
                    "type": "synonym"
                },
                {
                    "name": "timeless homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "timeless",
                    "type": "recommended"
                },
                {
                    "name": "Tim",
                    "type": "synonym"
                },
                {
                    "name": "fa95g04",
                    "type": "synonym"
                },
                {
                    "name": "fd23d07",
                    "type": "synonym"
                },
                {
                    "name": "im:6903167",
                    "type": "synonym"
                },
                {
                    "name": "timeless",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa95g04",
                    "type": "synonym"
                },
                {
                    "name": "wu:fd23d07",
                    "type": "synonym"
                }
            ],
            "record_id": "E7FGL0-1",
            "evidence": [
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9R1X4-1",
            "uniprot_ac": "Q9R1X4",
            "uniprot_id": "TIM_MOUSE",
            "refseq_ac": "NP_001129554",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein timeless homolog",
                    "type": "recommended"
                },
                {
                    "name": "mTim",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Timeless",
                    "type": "recommended"
                },
                {
                    "name": "Debt69",
                    "type": "synonym"
                },
                {
                    "name": "Tim1",
                    "type": "synonym"
                },
                {
                    "name": "Timeless1",
                    "type": "synonym"
                },
                {
                    "name": "Timeless",
                    "type": "synonym"
                },
                {
                    "name": "tim",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9R1X4-1",
            "evidence": [
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9UNS1-1",
            "uniprot_ac": "Q9UNS1",
            "uniprot_id": "TIM_HUMAN",
            "refseq_ac": "NP_001317224",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein timeless homolog",
                    "type": "recommended"
                },
                {
                    "name": "Tof1 homolog",
                    "type": "synonym"
                },
                {
                    "name": "hTIM",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog",
                    "type": "synonym"
                },
                {
                    "name": "timeless circadian clock 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TIMELESS",
                    "type": "recommended"
                },
                {
                    "name": "FASPS4",
                    "type": "synonym"
                },
                {
                    "name": "TIM1",
                    "type": "synonym"
                },
                {
                    "name": "TIMELESS1",
                    "type": "synonym"
                },
                {
                    "name": "TIMELESS",
                    "type": "synonym"
                },
                {
                    "name": "TIM",
                    "type": "synonym"
                },
                {
                    "name": "hTIM",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9UNS1-1",
            "evidence": [
                {
                    "id": "620015",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/620015"
                },
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P53840-1",
            "uniprot_ac": "P53840",
            "uniprot_id": "TOF1_YEAST",
            "refseq_ac": "NP_014126",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Topoisomerase 1-associated factor 1",
                    "type": "recommended"
                },
                {
                    "name": "Tof1p",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TOF1",
                    "type": "recommended"
                },
                {
                    "name": "N0636",
                    "type": "synonym"
                },
                {
                    "name": "TOF1",
                    "type": "synonym"
                }
            ],
            "record_id": "P53840-1",
            "evidence": [
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Z2Y1-1",
            "uniprot_ac": "Q9Z2Y1",
            "uniprot_id": "TIM_RAT",
            "refseq_ac": "NP_112630",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein timeless homolog",
                    "type": "recommended"
                },
                {
                    "name": "Timeless-like protein",
                    "type": "synonym"
                },
                {
                    "name": "protein timeless homolog",
                    "type": "synonym"
                },
                {
                    "name": "rTIM",
                    "type": "synonym"
                },
                {
                    "name": "rTLP",
                    "type": "synonym"
                },
                {
                    "name": "timeless circadian clock",
                    "type": "synonym"
                },
                {
                    "name": "timeless homolog",
                    "type": "synonym"
                },
                {
                    "name": "timeless-like protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Timeless",
                    "type": "recommended"
                },
                {
                    "name": "Timeless",
                    "type": "synonym"
                },
                {
                    "name": "Tim",
                    "type": "synonym"
                },
                {
                    "name": "rTIM",
                    "type": "synonym"
                },
                {
                    "name": "rTLP",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Z2Y1-1",
            "evidence": [
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8INH7-1",
            "uniprot_ac": "Q8INH7",
            "uniprot_id": "Q8INH7_DROME",
            "refseq_ac": "NP_524341",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG7855-PA",
                    "type": "synonym"
                },
                {
                    "name": "Timeout",
                    "type": "synonym"
                },
                {
                    "name": "timeless 2",
                    "type": "synonym"
                },
                {
                    "name": "timeless2",
                    "type": "synonym"
                },
                {
                    "name": "timeout-PA",
                    "type": "synonym"
                },
                {
                    "name": "timeout",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "timeout",
                    "type": "recommended"
                },
                {
                    "name": "CG14381",
                    "type": "synonym"
                },
                {
                    "name": "CG14382",
                    "type": "synonym"
                },
                {
                    "name": "CG7855",
                    "type": "synonym"
                },
                {
                    "name": "CG8148",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG7855",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG7855",
                    "type": "synonym"
                },
                {
                    "name": "TIM2",
                    "type": "synonym"
                },
                {
                    "name": "Tim-2",
                    "type": "synonym"
                },
                {
                    "name": "dtim2",
                    "type": "synonym"
                },
                {
                    "name": "tim2",
                    "type": "synonym"
                },
                {
                    "name": "timeout",
                    "type": "synonym"
                },
                {
                    "name": "tim",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8INH7-1",
            "evidence": [
                {
                    "id": "0061006",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061006"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0061006"
}