{
    "disease_id": "DOID:0060851",
    "recommended_name": {
        "id": "DOID:0060851",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060851",
        "name": "pemphigus vulgaris",
        "description": "A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance."
    },
    "synonyms": [
        {
            "id": "DOID:0060851",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060851",
            "name": "familial pemphigus vulgaris",
            "description": ""
        },
        {
            "id": "MONDO:0008219",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008219",
            "name": "pemphigus vulgaris",
            "description": "Pemphigus is a group of chronic autoimmune skin diseases characterized by blister formations on the outer layer of the skin and the mucous membranes. Three clinical forms have been characterized, of which pemphigus vulgaris is the most frequent (75%)."
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060851"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060851",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060851",
            "categories": []
        },
        {
            "id": "MONDO:0008219",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008219",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M2B5P7-1",
            "uniprot_ac": "A0A8M2B5P7",
            "uniprot_id": "A0A8M2B5P7_DANRE",
            "refseq_ac": "XP_005159251",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2dbb",
                    "type": "recommended"
                },
                {
                    "name": "DBB",
                    "type": "synonym"
                },
                {
                    "name": "mhc2d18b",
                    "type": "synonym"
                },
                {
                    "name": "mhc2dbb",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "si:dz241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153067",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2B5P7-1",
            "evidence": [
                {
                    "id": "0060851",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060851"
                }
            ]
        },
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            "glycoprotein": "no",
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                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "MHC class II",
                    "type": "synonym"
                },
                {
                    "name": "Uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2d8.45b1",
                    "type": "recommended"
                },
                {
                    "name": "mhc2d8.45b1",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-228j01.6",
                    "type": "synonym"
                },
                {
                    "name": "si:dz228j01.6",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1NAM7-1",
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                {
                    "id": "0060851",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060851"
                }
            ]
        },
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            "uniprot_canonical_ac": "H2EQR6-1",
            "uniprot_ac": "H2EQR6",
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            "glycoprotein": "yes",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Desmoglein-2.1",
                    "type": "recommended"
                },
                {
                    "name": "Dsg alpha",
                    "type": "synonym"
                },
                {
                    "name": "desmocollin a",
                    "type": "synonym"
                },
                {
                    "name": "desmoglein-2.1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "desmoglein-2.1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "dsg2.1",
                    "type": "recommended"
                },
                {
                    "name": "dsc",
                    "type": "synonym"
                },
                {
                    "name": "dsg2.1",
                    "type": "synonym"
                },
                {
                    "name": "dsg2",
                    "type": "synonym"
                },
                {
                    "name": "dsga",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-51f12.6",
                    "type": "synonym"
                },
                {
                    "name": "wu:fj23f02",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060851",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060851"
                }
            ]
        },
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            "uniprot_canonical_ac": "A0A8M2BIB6-1",
            "uniprot_ac": "A0A8M2BIB6",
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            "refseq_ac": "",
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                    "name": "Danio rerio",
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                    "glygen_name": "Zebrafish",
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                }
            ],
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                {
                    "name": "Desmoglein-2-like protein",
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            ],
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                {
                    "name": "dsg2l",
                    "type": "recommended"
                },
                {
                    "name": "dsgb",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2BIB6-1",
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                {
                    "id": "0060851",
                    "database": "AGR",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35902-1",
            "uniprot_ac": "O35902",
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            "refseq_ac": "NP_085099",
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            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Desmoglein-3",
                    "type": "recommended"
                },
                {
                    "name": "130 kDa pemphigus vulgaris antigen homolog",
                    "type": "synonym"
                },
                {
                    "name": "desmoglein-3 preproprotein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dsg3",
                    "type": "recommended"
                },
                {
                    "name": "Dsg3",
                    "type": "synonym"
                },
                {
                    "name": "bal",
                    "type": "synonym"
                }
            ],
            "record_id": "O35902-1",
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                {
                    "id": "0060851",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060851"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01921-1",
            "uniprot_ac": "P01921",
            "uniprot_id": "HB2D_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
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                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "H-2 class II histocompatibility antigen, A-D beta chain",
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                }
            ],
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                {
                    "name": "H2-Ab1",
                    "type": "recommended"
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                {
                    "name": "H2-iabeta",
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                    "id": "0060851",
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            ],
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                    "name": "Rano class II histocompatibility antigen, A beta chain",
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                    "name": "RT1 class II histocompatibility antigen, A beta chain",
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                    "id": "0060851",
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            "uniprot_canonical_ac": "P29826-1",
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                    "name": "RT1.B-beta(1)",
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            ],
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                    "id": "0060851",
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                }
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                    "name": "Estrogen receptor",
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                    "name": "E2 receptor alpha",
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                {
                    "name": "Estradiol receptor",
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                },
                {
                    "name": "Nuclear receptor subfamily 3 group A member 1",
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                },
                {
                    "name": "estradiol receptor",
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                    "name": "estrogen nuclear receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor alpha E1-E2-1-2",
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                {
                    "name": "estrogen receptor alpha E1-N2-E2-1-2",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor isoform 1",
                    "type": "synonym"
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                {
                    "name": "nuclear receptor subfamily 3 group A member 1",
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            ],
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                    "name": "Desmoglein-3",
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                {
                    "name": "130 kDa pemphigus vulgaris antigen",
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                    "name": "cadherin family member 6",
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                    "id": "0060851",
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                    "name": "IDDM1",
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                    "id": "0060851",
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                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060851"
}