{
    "disease_id": "DOID:0060611",
    "recommended_name": {
        "id": "DOID:0060611",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060611",
        "name": "abdominal obesity-metabolic syndrome",
        "description": "A syndrome that is characterized by abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease."
    },
    "synonyms": [
        {
            "id": "MONDO:0011565",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "name": "metabolic syndrome X",
            "description": ""
        },
        {
            "id": "MONDO:0011565",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "name": "abdominal obesity-metabolic syndrome 1",
            "description": ""
        },
        {
            "id": "MONDO:0011565",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "name": "metabolic syndrome type X",
            "description": ""
        },
        {
            "id": "MONDO:0011565",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "name": "AOMS1",
            "description": ""
        },
        {
            "id": "MONDO:0011565",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "name": "abdominal obesity metabolic syndrome",
            "description": ""
        }
    ],
    "children": [
        {
            "id": "DOID:0060612",
            "label": "abdominal obesity-metabolic syndrome 3",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0080945",
            "label": "abdominal obesity-metabolic syndrome 4",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:14221",
            "label": "abdominal obesity-metabolic syndrome 1",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0060612",
        "DOID:0080945",
        "DOID:0060611",
        "DOID:14221"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060611",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060611",
            "categories": []
        },
        {
            "id": "MONDO:0011565",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011565",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AC58G1P7-1",
            "uniprot_ac": "A0AC58G1P7",
            "uniprot_id": "A0AC58G1P7_DANRE",
            "refseq_ac": "XP_073763663",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha",
                    "type": "recommended"
                },
                {
                    "name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ppargc1a",
                    "type": "recommended"
                },
                {
                    "name": "ppargc1a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AC58G1P7-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q90XF2-1",
            "uniprot_ac": "Q90XF2",
            "uniprot_id": "KPCI_DANRE",
            "refseq_ac": "NP_571930",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein kinase C iota type",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.13",
                    "type": "synonym"
                },
                {
                    "name": "Atypical protein kinase C-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "Heart and soul protein",
                    "type": "synonym"
                },
                {
                    "name": "aPKC-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "atypical protein kinase C-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "heart and soul protein",
                    "type": "synonym"
                },
                {
                    "name": "nPKC-iota",
                    "type": "synonym"
                },
                {
                    "name": "protein kinase C iota type",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "prkci",
                    "type": "recommended"
                },
                {
                    "name": "aPKC[l]",
                    "type": "synonym"
                },
                {
                    "name": "hal",
                    "type": "synonym"
                },
                {
                    "name": "has",
                    "type": "synonym"
                },
                {
                    "name": "prkci",
                    "type": "synonym"
                }
            ],
            "record_id": "Q90XF2-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ACD6B6Z2-1",
            "uniprot_ac": "A0ACD6B6Z2",
            "uniprot_id": "A0ACD6B6Z2_DANRE",
            "refseq_ac": "XP_696628",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Guanylate cyclase",
                    "type": "recommended"
                },
                {
                    "name": "4.6.1.2",
                    "type": "synonym"
                },
                {
                    "name": "guanylyl cyclase C isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "gucy2cb",
                    "type": "recommended"
                },
                {
                    "name": "gucy2cb",
                    "type": "synonym"
                }
            ],
            "record_id": "A0ACD6B6Z2-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A2R8QMP7-1",
            "uniprot_ac": "A0A2R8QMP7",
            "uniprot_id": "A0A2R8QMP7_DANRE",
            "refseq_ac": "XP_009301762",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "sirt3",
                    "type": "recommended"
                },
                {
                    "name": "sirt3",
                    "type": "synonym"
                },
                {
                    "name": "zgc:158774",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A2R8QMP7-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q3UWA6-1",
            "uniprot_ac": "Q3UWA6",
            "uniprot_id": "GUC2C_MOUSE",
            "refseq_ac": "NP_001120790",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Guanylyl cyclase C",
                    "type": "recommended"
                },
                {
                    "name": "4.6.1.2",
                    "type": "synonym"
                },
                {
                    "name": "GC-C",
                    "type": "synonym"
                },
                {
                    "name": "Heat-stable enterotoxin receptor",
                    "type": "synonym"
                },
                {
                    "name": "Intestinal guanylate cyclase",
                    "type": "synonym"
                },
                {
                    "name": "STA receptor",
                    "type": "synonym"
                },
                {
                    "name": "guanylyl cyclase C isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "guanylyl cyclase C",
                    "type": "synonym"
                },
                {
                    "name": "heat-stable enterotoxin receptor",
                    "type": "synonym"
                },
                {
                    "name": "intestinal guanylate cyclase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gucy2c",
                    "type": "recommended"
                },
                {
                    "name": "GC-C",
                    "type": "synonym"
                },
                {
                    "name": "Gcc",
                    "type": "synonym"
                },
                {
                    "name": "Guc2c",
                    "type": "synonym"
                },
                {
                    "name": "Gucy2c",
                    "type": "synonym"
                }
            ],
            "record_id": "Q3UWA6-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q3UNX5-1",
            "uniprot_ac": "Q3UNX5",
            "uniprot_id": "ACSM3_MOUSE",
            "refseq_ac": "NP_058566",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Acyl-coenzyme A synthetase ACSM3, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "6.2.1.17",
                    "type": "synonym"
                },
                {
                    "name": "6.2.1.2",
                    "type": "synonym"
                },
                {
                    "name": "Acyl-CoA synthetase medium-chain family member 3",
                    "type": "synonym"
                },
                {
                    "name": "Butyrate--CoA ligase 3",
                    "type": "synonym"
                },
                {
                    "name": "Butyryl-coenzyme A synthetase 3",
                    "type": "synonym"
                },
                {
                    "name": "Middle-chain acyl-CoA synthetase 3",
                    "type": "synonym"
                },
                {
                    "name": "Propionate--CoA ligase",
                    "type": "synonym"
                },
                {
                    "name": "Protein SA homolog",
                    "type": "synonym"
                },
                {
                    "name": "SA hypertension-associated homolog",
                    "type": "synonym"
                },
                {
                    "name": "acyl-coenzyme A synthetase ACSM3, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "butyrate--CoA ligase 3",
                    "type": "synonym"
                },
                {
                    "name": "butyryl-coenzyme A synthetase 3",
                    "type": "synonym"
                },
                {
                    "name": "middle-chain acyl-CoA synthetase 3",
                    "type": "synonym"
                },
                {
                    "name": "propionate--CoA ligase",
                    "type": "synonym"
                },
                {
                    "name": "protein SA homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Acsm3",
                    "type": "recommended"
                },
                {
                    "name": "Acsm3",
                    "type": "synonym"
                },
                {
                    "name": "Sah",
                    "type": "synonym"
                },
                {
                    "name": "Sa",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P37238-1",
            "uniprot_ac": "P37238",
            "uniprot_id": "PPARG_MOUSE",
            "refseq_ac": "NP_001120802",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Peroxisome proliferator-activated receptor gamma",
                    "type": "recommended"
                },
                {
                    "name": "Nuclear receptor subfamily 1 group C member 3",
                    "type": "synonym"
                },
                {
                    "name": "PPAR-gamma",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 1 group C member 3",
                    "type": "synonym"
                },
                {
                    "name": "peroxisome proliferator activated receptor gamma 2",
                    "type": "synonym"
                },
                {
                    "name": "peroxisome proliferator activated receptor gamma 4",
                    "type": "synonym"
                },
                {
                    "name": "peroxisome proliferator-activated receptor gamma isoform 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Pparg",
                    "type": "recommended"
                },
                {
                    "name": "Nr1c3",
                    "type": "synonym"
                },
                {
                    "name": "PPAR-gamma2",
                    "type": "synonym"
                },
                {
                    "name": "PPAR-gamma",
                    "type": "synonym"
                },
                {
                    "name": "PPARG",
                    "type": "synonym"
                },
                {
                    "name": "PPARgamma2",
                    "type": "synonym"
                },
                {
                    "name": "PPARgamma",
                    "type": "synonym"
                },
                {
                    "name": "Pparg",
                    "type": "synonym"
                }
            ],
            "record_id": "P37238-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8R104-1",
            "uniprot_ac": "Q8R104",
            "uniprot_id": "SIR3_MOUSE",
            "refseq_ac": "NP_001120823",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "NAD-dependent protein deacetylase sirtuin-3",
                    "type": "recommended"
                },
                {
                    "name": "2.3.1.-",
                    "type": "synonym"
                },
                {
                    "name": "2.3.1.286",
                    "type": "synonym"
                },
                {
                    "name": "NAD-dependent deacetylase sirtuin-3",
                    "type": "synonym"
                },
                {
                    "name": "NAD-dependent protein deacetylase sirtuin-3 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "NAD-dependent protein deacetylase sirtuin-3",
                    "type": "synonym"
                },
                {
                    "name": "NAD-dependent protein delactylase sirtuin-3",
                    "type": "synonym"
                },
                {
                    "name": "Regulatory protein SIR2 homolog 3",
                    "type": "synonym"
                },
                {
                    "name": "SIR2-like protein 3",
                    "type": "synonym"
                },
                {
                    "name": "SIRT3L mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "mSIR2L3",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial protein lysine deacetylase",
                    "type": "synonym"
                },
                {
                    "name": "regulatory protein SIR2 homolog 3",
                    "type": "synonym"
                },
                {
                    "name": "silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sirt3",
                    "type": "recommended"
                },
                {
                    "name": "2310003L23Rik",
                    "type": "synonym"
                },
                {
                    "name": "Sir2l3",
                    "type": "synonym"
                },
                {
                    "name": "Sirt3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8R104-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q60753-1",
            "uniprot_ac": "Q60753",
            "uniprot_id": "CTF1_MOUSE",
            "refseq_ac": "NP_031821",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cardiotrophin-1",
                    "type": "recommended"
                },
                {
                    "name": "CT-1",
                    "type": "synonym"
                },
                {
                    "name": "cardiotrophin-1 isoform 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ctf1",
                    "type": "recommended"
                },
                {
                    "name": "CT-1",
                    "type": "synonym"
                },
                {
                    "name": "Ctf1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q60753-1",
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q62074-1",
            "uniprot_ac": "Q62074",
            "uniprot_id": "KPCI_MOUSE",
            "refseq_ac": "NP_032883",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein kinase C iota type",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.13",
                    "type": "synonym"
                },
                {
                    "name": "Atypical protein kinase C-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "aPKC-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "atypical protein kinase C-lambda/iota",
                    "type": "synonym"
                },
                {
                    "name": "nPKC-iota",
                    "type": "synonym"
                },
                {
                    "name": "protein kinase C iota type isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "protein kinase C iota type",
                    "type": "synonym"
                },
                {
                    "name": "protein kinase C, lambda",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Prkci",
                    "type": "recommended"
                },
                {
                    "name": "2310021H13Rik",
                    "type": "synonym"
                },
                {
                    "name": "PKClambda",
                    "type": "synonym"
                },
                {
                    "name": "Pkci",
                    "type": "synonym"
                },
                {
                    "name": "Pkcl",
                    "type": "synonym"
                },
                {
                    "name": "Prkci",
                    "type": "synonym"
                },
                {
                    "name": "Prkcl",
                    "type": "synonym"
                },
                {
                    "name": "aPKClambda",
                    "type": "synonym"
                },
                {
                    "name": "mKIAA4165",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62074-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8K4Q6-1",
            "uniprot_ac": "Q8K4Q6",
            "uniprot_id": "NEIL1_MOUSE",
            "refseq_ac": "NP_082623",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Endonuclease 8-like 1",
                    "type": "recommended"
                },
                {
                    "name": "3.2.2.-",
                    "type": "synonym"
                },
                {
                    "name": "4.2.99.18",
                    "type": "synonym"
                },
                {
                    "name": "DNA glycosylase/AP lyase Neil1",
                    "type": "synonym"
                },
                {
                    "name": "DNA-(apurinic or apyrimidinic site) lyase Neil1",
                    "type": "synonym"
                },
                {
                    "name": "Endonuclease VIII-like 1",
                    "type": "synonym"
                },
                {
                    "name": "NEH1",
                    "type": "synonym"
                },
                {
                    "name": "Nei homolog 1",
                    "type": "synonym"
                },
                {
                    "name": "Nei-like protein 1",
                    "type": "synonym"
                },
                {
                    "name": "endonuclease 8-like 1 isoform 1",
                    "type": "synonym"
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                {
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                {
                    "name": "Dmel_CG10777",
                    "type": "synonym"
                },
                {
                    "name": "Mahe",
                    "type": "synonym"
                },
                {
                    "name": "cg10777",
                    "type": "synonym"
                },
                {
                    "name": "dDDX5",
                    "type": "synonym"
                },
                {
                    "name": "dmDDX17",
                    "type": "synonym"
                },
                {
                    "name": "dmDDX1",
                    "type": "synonym"
                },
                {
                    "name": "dmMahe",
                    "type": "synonym"
                },
                {
                    "name": "mahe",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P19109-1",
            "uniprot_ac": "P19109",
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            "refseq_ac": "NP_001163528",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
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                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "ATP-dependent RNA helicase p62",
                    "type": "recommended"
                },
                {
                    "name": "3.6.4.13",
                    "type": "synonym"
                },
                {
                    "name": "CG10279-PH",
                    "type": "synonym"
                },
                {
                    "name": "Lighten-up",
                    "type": "synonym"
                },
                {
                    "name": "Rm62, isoform H",
                    "type": "synonym"
                },
                {
                    "name": "Rm62-PH",
                    "type": "synonym"
                },
                {
                    "name": "helicase p62",
                    "type": "synonym"
                },
                {
                    "name": "lighten up",
                    "type": "synonym"
                },
                {
                    "name": "p68 RNA helicase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rm62",
                    "type": "recommended"
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                {
                    "name": "4136",
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                },
                {
                    "name": "CG10279",
                    "type": "synonym"
                },
                {
                    "name": "DmRH8",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG10279",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG10279",
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                {
                    "name": "Dmp68",
                    "type": "synonym"
                },
                {
                    "name": "Lip",
                    "type": "synonym"
                },
                {
                    "name": "RM62",
                    "type": "synonym"
                },
                {
                    "name": "Rm62",
                    "type": "synonym"
                },
                {
                    "name": "dmP68",
                    "type": "synonym"
                },
                {
                    "name": "l(3)01086",
                    "type": "synonym"
                },
                {
                    "name": "l(3)j3D2",
                    "type": "synonym"
                },
                {
                    "name": "l(3)j3D5",
                    "type": "synonym"
                },
                {
                    "name": "l(3)rG338",
                    "type": "synonym"
                },
                {
                    "name": "l(3)s5196",
                    "type": "synonym"
                },
                {
                    "name": "p62",
                    "type": "synonym"
                },
                {
                    "name": "p68",
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                },
                {
                    "name": "rm62",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "CG9809-PE",
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                },
                {
                    "name": "PGC-1/spargel",
                    "type": "synonym"
                },
                {
                    "name": "PPARG coactivator 1alpha",
                    "type": "synonym"
                },
                {
                    "name": "PPARGC1A",
                    "type": "synonym"
                },
                {
                    "name": "Spargel, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Spargel, isoform E",
                    "type": "synonym"
                },
                {
                    "name": "peroxisome proliferator-activated receptor gamma coactivator 1",
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                },
                {
                    "name": "peroxisome proliferator-activated receptor gamma coactivator-1alpha",
                    "type": "synonym"
                },
                {
                    "name": "spargel, isoform E",
                    "type": "synonym"
                },
                {
                    "name": "srl-PE",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "srl",
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                {
                    "name": "CG 9809",
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                },
                {
                    "name": "CG9809",
                    "type": "synonym"
                },
                {
                    "name": "DmPGC-1/spargel",
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                {
                    "name": "DmPGC-1alpha",
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                {
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                {
                    "name": "Dmel\\CG9809",
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                {
                    "name": "Dmel_CG9809",
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                {
                    "name": "PCG1-alpha",
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                },
                {
                    "name": "PGC-1-alpha",
                    "type": "synonym"
                },
                {
                    "name": "PGC-1alpha",
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                },
                {
                    "name": "PGC-1",
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                },
                {
                    "name": "PGC1-alpha",
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                },
                {
                    "name": "PGC1a",
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                },
                {
                    "name": "PGC1",
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                },
                {
                    "name": "Spargel",
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                },
                {
                    "name": "Srl",
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                },
                {
                    "name": "cg9809",
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                },
                {
                    "name": "dPCG1alpha",
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                },
                {
                    "name": "dPGC-1alpha",
                    "type": "synonym"
                },
                {
                    "name": "dPGC-1",
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                },
                {
                    "name": "dPGC1",
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                },
                {
                    "name": "dPGC",
                    "type": "synonym"
                },
                {
                    "name": "dh-PPRC1",
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                },
                {
                    "name": "spargel",
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                },
                {
                    "name": "srl",
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                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1Z9X0-1",
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                }
            ],
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                {
                    "name": "Atypical protein kinase C",
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                {
                    "name": "2.7.11.13",
                    "type": "synonym"
                },
                {
                    "name": "CG42783-PC",
                    "type": "synonym"
                },
                {
                    "name": "aPKC-PC",
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                },
                {
                    "name": "atypical PKC",
                    "type": "synonym"
                },
                {
                    "name": "atypical protein kinase C, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "atypical protein kinase C",
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                },
                {
                    "name": "atypical protein kinase",
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                },
                {
                    "name": "atypical-Protein kinase C",
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                },
                {
                    "name": "pschur",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "aPKC",
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                {
                    "name": "CG10261",
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                },
                {
                    "name": "CG30475",
                    "type": "synonym"
                },
                {
                    "name": "CG42783",
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                },
                {
                    "name": "DaPKC",
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                {
                    "name": "Dmel\\CG42783",
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                {
                    "name": "Dmel_CG42783",
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                {
                    "name": "PKCl",
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                },
                {
                    "name": "PKCzeta",
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                },
                {
                    "name": "PKC",
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                },
                {
                    "name": "a-PKC",
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                },
                {
                    "name": "aPKC zeta",
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                },
                {
                    "name": "aPKC-zeta",
                    "type": "synonym"
                },
                {
                    "name": "aPKCzeta",
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                {
                    "name": "aPKC",
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                {
                    "name": "aPkc",
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                },
                {
                    "name": "alphaPKCzeta",
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                },
                {
                    "name": "alphaPKC",
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                },
                {
                    "name": "apkc",
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                },
                {
                    "name": "daPKC",
                    "type": "synonym"
                },
                {
                    "name": "dapkc",
                    "type": "synonym"
                },
                {
                    "name": "i",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k06403",
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                },
                {
                    "name": "pkc-3",
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                {
                    "name": "psu",
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                }
            ],
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                    "id": "0060611",
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                }
            ]
        },
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            "uniprot_canonical_ac": "Q7JQ32-1",
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                {
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Receptor-type guanylate cyclase Gyc76C",
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                },
                {
                    "name": "CG42636-PA",
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                {
                    "name": "DrGC-1",
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                },
                {
                    "name": "Gyc76C-PA",
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                },
                {
                    "name": "gimli",
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                {
                    "name": "guanylyl cyclase at 76C, isoform A",
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                {
                    "name": "l(3)76BDl",
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                {
                    "name": "lethal (3) L0090",
                    "type": "synonym"
                },
                {
                    "name": "receptor-type guanylate cyclase",
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                }
            ],
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                {
                    "name": "Gyc76C",
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                    "name": "CG32215",
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                },
                {
                    "name": "CG42636",
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                },
                {
                    "name": "CG8742",
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                    "name": "DGC1",
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                {
                    "name": "Dmel\\CG42636",
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                    "name": "DrGC-1",
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                    "name": "GYC 76C",
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                {
                    "name": "Gyc76C",
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                },
                {
                    "name": "drgc",
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                },
                {
                    "name": "gim",
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                },
                {
                    "name": "gyc76C",
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                },
                {
                    "name": "l(3)76BDl",
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                },
                {
                    "name": "l(3)L0090",
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                }
            ],
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                    "id": "0060611",
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                }
            ]
        },
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                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "Guanylate cyclase",
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                {
                    "name": "CG10738-PD",
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                {
                    "name": "uncharacterized protein, isoform D",
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                }
            ],
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                    "name": "EHR",
                    "type": "recommended"
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                {
                    "name": "CG10738",
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                },
                {
                    "name": "Dmel\\CG10738",
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                {
                    "name": "Dmel_CG10738",
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                {
                    "name": "GYC",
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            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q07553-1",
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                {
                    "name": "Drosophila melanogaster",
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                }
            ],
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                {
                    "name": "Guanylate cyclase 32E",
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                    "name": "4.6.1.2",
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                },
                {
                    "name": "CG33114-PD",
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                },
                {
                    "name": "Gyc32E-PD",
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                },
                {
                    "name": "guanyl cyclase at 32E",
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                },
                {
                    "name": "guanylate cyclase receptor-type",
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                },
                {
                    "name": "guanylyl cyclase at 32E, isoform D",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Gyc32E",
                    "type": "recommended"
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                {
                    "name": "CG33114",
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                },
                {
                    "name": "CG6275",
                    "type": "synonym"
                },
                {
                    "name": "Cyg1",
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                },
                {
                    "name": "DMRGC",
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                },
                {
                    "name": "Dmel\\CG33114",
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                {
                    "name": "Dmel_CG33114",
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                {
                    "name": "GC",
                    "type": "synonym"
                },
                {
                    "name": "GYC 32E",
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                },
                {
                    "name": "Gyc-r",
                    "type": "synonym"
                },
                {
                    "name": "Gyc32E",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1ZB47-1",
            "uniprot_ac": "A1ZB47",
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            "refseq_ac": "NP_001033958",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "guanylate cyclase",
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                    "name": "4.6.1.2",
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                },
                {
                    "name": "CG33958-PA",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CG5719",
                    "type": "recommended"
                },
                {
                    "name": "CG14501",
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                },
                {
                    "name": "CG33958",
                    "type": "synonym"
                },
                {
                    "name": "CG5719",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG33958",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG33958",
                    "type": "synonym"
                },
                {
                    "name": "GYC",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A4V243-1",
            "uniprot_ac": "A4V243",
            "uniprot_id": "A4V243_DROME",
            "refseq_ac": "NP_001007096",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Guanylate cyclase",
                    "type": "recommended"
                },
                {
                    "name": "4.6.1.2",
                    "type": "synonym"
                },
                {
                    "name": "CG42637-PC",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein, isoform C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG42637",
                    "type": "recommended"
                },
                {
                    "name": "CG42637",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG42637",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG42637",
                    "type": "synonym"
                }
            ],
            "record_id": "A4V243-1",
            "evidence": [
                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q14406-1",
            "uniprot_ac": "Q14406",
            "uniprot_id": "CSHL_HUMAN",
            "refseq_ac": "NP_072101",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Chorionic somatomammotropin hormone-like 1",
                    "type": "recommended"
                },
                {
                    "name": "Chorionic somatomammotropin-like",
                    "type": "synonym"
                },
                {
                    "name": "Lactogen-like",
                    "type": "synonym"
                },
                {
                    "name": "chorionic somatomammotropin CS-5",
                    "type": "synonym"
                },
                {
                    "name": "chorionic somatomammotropin hormone-like 1 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "growth hormone B4",
                    "type": "synonym"
                },
                {
                    "name": "growth hormone cluster",
                    "type": "synonym"
                }
            ],
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                    "name": "CSHL1",
                    "type": "recommended"
                },
                {
                    "name": "CS-5",
                    "type": "synonym"
                },
                {
                    "name": "CSHL1",
                    "type": "synonym"
                },
                {
                    "name": "CSHP1",
                    "type": "synonym"
                },
                {
                    "name": "CSL",
                    "type": "synonym"
                },
                {
                    "name": "GHB4",
                    "type": "synonym"
                },
                {
                    "name": "hCS-L",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0060611",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060611"
                }
            ]
        },
        {
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                    "taxid": 9606,
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                }
            ],
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                    "name": "Complement factor D",
                    "type": "recommended"
                },
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                    "name": "3.4.21.46",
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                },
                {
                    "name": "Adipsin",
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                },
                {
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                    "type": "synonym"
                },
                {
                    "name": "D component of complement (adipsin)",
                    "type": "synonym"
                },
                {
                    "name": "Properdin factor D",
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                },
                {
                    "name": "complement factor D isoform 2 precursor",
                    "type": "synonym"
                },
                {
                    "name": "complement factor D preproprotein",
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                },
                {
                    "name": "properdin factor D",
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                }
            ],
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                    "name": "CFD",
                    "type": "recommended"
                },
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                    "name": "ADIPSIN",
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                },
                {
                    "name": "ADN",
                    "type": "synonym"
                },
                {
                    "name": "CFD",
                    "type": "synonym"
                },
                {
                    "name": "DF",
                    "type": "synonym"
                },
                {
                    "name": "PFD",
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                }
            ],
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                    "id": "0060611",
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                }
            ]
        },
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                }
            ],
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                },
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                {
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                {
                    "name": "RNA helicase p68",
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                },
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                }
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                    "name": "DDX5",
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                    "name": "G17P1",
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                    "name": "HELR",
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                    "name": "HLR1",
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                {
                    "name": "HUMP68",
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                    "id": "0060611",
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            ]
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                {
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                {
                    "name": "DEAD box protein p82",
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                },
                {
                    "name": "DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)",
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                    "name": "RH70",
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                    "id": "0060611",
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            ]
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                {
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            ]
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                {
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                }
            ],
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                    "name": "2.7.11.13",
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                },
                {
                    "name": "Atypical protein kinase C-lambda/iota",
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                {
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                },
                {
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                {
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                {
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            ]
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                {
                    "name": "cardiophin 1",
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                {
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                }
            ],
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                {
                    "name": "Glucose transporter type 9",
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                },
                {
                    "name": "Urate transporter",
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                {
                    "name": "glucose transporter type 9",
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                {
                    "name": "human glucose transporter-like protein-9",
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                {
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                }
            ]
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                    "name": "Homo sapiens",
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                }
            ],
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                    "name": "Peroxisome proliferator-activated receptor gamma",
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                },
                {
                    "name": "PPAR-gamma",
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                {
                    "name": "nuclear receptor subfamily 1 group C member 3",
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                },
                {
                    "name": "peroxisome proliferator-activated receptor gamma isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "peroxisome proliferator-activated receptor-gamma 5",
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                },
                {
                    "name": "peroxisome proliferator-activated receptor-gamma splicing",
                    "type": "synonym"
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                    "name": "PPARG",
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                {
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                },
                {
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                },
                {
                    "name": "GLM1",
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                {
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                },
                {
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                },
                {
                    "name": "PPARG2",
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                },
                {
                    "name": "PPARG5",
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                {
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                {
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                    "name": "sirtuin type 3",
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    "biomarkers": [],
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}