{
    "disease_id": "DOID:0060584",
    "recommended_name": {
        "id": "DOID:0060584",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060584",
        "name": "Noonan syndrome 6",
        "description": "A Noonan syndrome that has_material_basis_in heterozygous mutation in the NRAS gene on chromosome 1p13."
    },
    "synonyms": [
        {
            "id": "DOID:0060584",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060584",
            "name": "NS6",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "Noonan syndrome 6",
            "description": "Any Noonan syndrome in which the cause of the disease is a mutation in the NRAS gene."
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "NRAS Noonan syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "NS6",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "Noonan syndrome 6",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "Noonan syndrome caused by mutation in NRAS",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "Noonan syndrome type 6",
            "description": ""
        },
        {
            "id": "MONDO:0013186",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "name": "NRAS gene related Noonan syndrome",
            "description": ""
        },
        {
            "id": "MIM:613224",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/613224",
            "name": "Noonan syndrome 6",
            "description": "Noonan syndrome 6"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060584"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060584",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060584",
            "categories": []
        },
        {
            "id": "MONDO:0013186",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013186",
            "categories": []
        },
        {
            "id": "MIM:613224",
            "database": "MIM",
            "url": "https://www.omim.org/entry/613224",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P79737-1",
            "uniprot_ac": "P79737",
            "uniprot_id": "RASN_DANRE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "GTPase NRas",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "Transforming protein N-Ras",
                    "type": "synonym"
                },
                {
                    "name": "ZRas-B1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "nras",
                    "type": "recommended"
                }
            ],
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            "evidence": [
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060584"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08556-1",
            "uniprot_ac": "P08556",
            "uniprot_id": "RASN_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "GTPase NRas",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "Transforming protein N-Ras",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nras",
                    "type": "recommended"
                }
            ],
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01111-1",
            "uniprot_ac": "P01111",
            "uniprot_id": "RASN_HUMAN",
            "refseq_ac": "NP_002515",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "GTPase NRas",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "GTPase NRas",
                    "type": "synonym"
                },
                {
                    "name": "N-ras protein part 4",
                    "type": "synonym"
                },
                {
                    "name": "Transforming protein N-Ras",
                    "type": "synonym"
                },
                {
                    "name": "neuroblastoma RAS viral (v-ras) oncogene homolog",
                    "type": "synonym"
                },
                {
                    "name": "proto-oncogene GTPase",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein N-Ras",
                    "type": "synonym"
                },
                {
                    "name": "v-ras neuroblastoma RAS viral oncogene homolog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NRAS",
                    "type": "recommended"
                },
                {
                    "name": "ALPS4",
                    "type": "synonym"
                },
                {
                    "name": "CMNS",
                    "type": "synonym"
                },
                {
                    "name": "HRAS1",
                    "type": "synonym"
                },
                {
                    "name": "N-ras",
                    "type": "synonym"
                },
                {
                    "name": "NCMS",
                    "type": "synonym"
                },
                {
                    "name": "NRAS1",
                    "type": "synonym"
                },
                {
                    "name": "NRAS",
                    "type": "synonym"
                },
                {
                    "name": "NS6",
                    "type": "synonym"
                },
                {
                    "name": "RALD1",
                    "type": "synonym"
                }
            ],
            "record_id": "P01111-1",
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                {
                    "id": "613224",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/613224"
                },
                {
                    "id": "0060584",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060584"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q04970-1",
            "uniprot_ac": "Q04970",
            "uniprot_id": "RASN_RAT",
            "refseq_ac": "NP_542944",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "GTPase NRas",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "GTPase NRas",
                    "type": "synonym"
                },
                {
                    "name": "Transforming protein N-Ras",
                    "type": "synonym"
                },
                {
                    "name": "neuroblastoma RAS viral (v-ras) oncogene homolog",
                    "type": "synonym"
                },
                {
                    "name": "neuroblastoma RAS viral oncogene homolog",
                    "type": "synonym"
                },
                {
                    "name": "neuroblastoma ras oncogene",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein N-Ras",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nras",
                    "type": "recommended"
                },
                {
                    "name": "Nras",
                    "type": "synonym"
                }
            ],
            "record_id": "Q04970-1",
            "evidence": [
                {
                    "id": "0060584",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060584"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08646-1",
            "uniprot_ac": "P08646",
            "uniprot_id": "RAS1_DROME",
            "refseq_ac": "NP_476699",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ras-like protein 1",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "CG9375-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dmras85D",
                    "type": "synonym"
                },
                {
                    "name": "Dras1",
                    "type": "synonym"
                },
                {
                    "name": "Ras GTPase",
                    "type": "synonym"
                },
                {
                    "name": "Ras oncogene at 85B",
                    "type": "synonym"
                },
                {
                    "name": "Ras oncogene at 85D",
                    "type": "synonym"
                },
                {
                    "name": "Ras1",
                    "type": "synonym"
                },
                {
                    "name": "Ras85D-PA",
                    "type": "synonym"
                },
                {
                    "name": "enhancer of faf",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ras85D",
                    "type": "recommended"
                },
                {
                    "name": "C-ras1",
                    "type": "synonym"
                },
                {
                    "name": "CG9375",
                    "type": "synonym"
                },
                {
                    "name": "D-Ras1",
                    "type": "synonym"
                },
                {
                    "name": "D-Ras",
                    "type": "synonym"
                },
                {
                    "name": "D-ras-1",
                    "type": "synonym"
                },
                {
                    "name": "D-ras1",
                    "type": "synonym"
                },
                {
                    "name": "DRAS1",
                    "type": "synonym"
                },
                {
                    "name": "DRas85D/Ras",
                    "type": "synonym"
                },
                {
                    "name": "DRas",
                    "type": "synonym"
                },
                {
                    "name": "Dm Ras1",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9375",
                    "type": "synonym"
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                {
                    "name": "Dmras85D",
                    "type": "synonym"
                },
                {
                    "name": "Dras1",
                    "type": "synonym"
                },
                {
                    "name": "Dras85D",
                    "type": "synonym"
                },
                {
                    "name": "Dras",
                    "type": "synonym"
                },
                {
                    "name": "E(faf)",
                    "type": "synonym"
                },
                {
                    "name": "E(sev)3C",
                    "type": "synonym"
                },
                {
                    "name": "EC3-3",
                    "type": "synonym"
                },
                {
                    "name": "EK3-4",
                    "type": "synonym"
                },
                {
                    "name": "P08646",
                    "type": "synonym"
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                {
                    "name": "RAS1",
                    "type": "synonym"
                },
                {
                    "name": "RAS85D",
                    "type": "synonym"
                },
                {
                    "name": "RAS",
                    "type": "synonym"
                },
                {
                    "name": "RTK",
                    "type": "synonym"
                },
                {
                    "name": "Ras 85D",
                    "type": "synonym"
                },
                {
                    "name": "Ras-1",
                    "type": "synonym"
                },
                {
                    "name": "Ras.85D",
                    "type": "synonym"
                },
                {
                    "name": "Ras1/RAs85D",
                    "type": "synonym"
                },
                {
                    "name": "Ras185D",
                    "type": "synonym"
                },
                {
                    "name": "Ras1",
                    "type": "synonym"
                },
                {
                    "name": "Ras85DNt",
                    "type": "synonym"
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                {
                    "name": "Ras85D",
                    "type": "synonym"
                },
                {
                    "name": "Ras85d",
                    "type": "synonym"
                },
                {
                    "name": "Ras85",
                    "type": "synonym"
                },
                {
                    "name": "RasI",
                    "type": "synonym"
                },
                {
                    "name": "RasV12",
                    "type": "synonym"
                },
                {
                    "name": "Ras[V12]",
                    "type": "synonym"
                },
                {
                    "name": "Rasv12",
                    "type": "synonym"
                },
                {
                    "name": "Ras",
                    "type": "synonym"
                },
                {
                    "name": "S35097",
                    "type": "synonym"
                },
                {
                    "name": "Su(tor)3-2",
                    "type": "synonym"
                },
                {
                    "name": "dRAS1",
                    "type": "synonym"
                },
                {
                    "name": "dRas1",
                    "type": "synonym"
                },
                {
                    "name": "dRas85D",
                    "type": "synonym"
                },
                {
                    "name": "dRas",
                    "type": "synonym"
                },
                {
                    "name": "dras1",
                    "type": "synonym"
                },
                {
                    "name": "fs(3)05703",
                    "type": "synonym"
                },
                {
                    "name": "l(3)06677",
                    "type": "synonym"
                },
                {
                    "name": "l(3)s1747",
                    "type": "synonym"
                },
                {
                    "name": "p21[Ras1]",
                    "type": "synonym"
                },
                {
                    "name": "ras 1",
                    "type": "synonym"
                },
                {
                    "name": "ras1",
                    "type": "synonym"
                },
                {
                    "name": "ras85B",
                    "type": "synonym"
                },
                {
                    "name": "ras85D",
                    "type": "synonym"
                },
                {
                    "name": "ras[V12]",
                    "type": "synonym"
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                {
                    "name": "ras",
                    "type": "synonym"
                }
            ],
            "record_id": "P08646-1",
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                {
                    "id": "0060584",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060584"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060584"
}