{
    "disease_id": "DOID:0060466",
    "recommended_name": {
        "id": "DOID:0060466",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060466",
        "name": "gingival fibromatosis",
        "description": "A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa."
    },
    "synonyms": [
        {
            "id": "DOID:0060466",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060466",
            "name": "hereditary gingival fibromatosis",
            "description": ""
        },
        {
            "id": "DOID:0060466",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060466",
            "name": "hereditary gingival hyperplasia",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "fibromatosis, gingival, 1",
            "description": "Any gingival fibromatosis in which the cause of the disease is a mutation in the SOS1 gene."
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "SOS1 gingival fibromatosis",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "SOS1 hereditary gingival fibromatosis",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "fibromatosis, gingival, 1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "fibromatosis, gingival, type 1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "gingival fibromatosis caused by mutation in SOS1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "hereditary gingival fibromatosis caused by mutation in SOS1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "GGF1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "GINGF",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "GINGF1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "HGF1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "fibromatosis gingival, hereditary, 1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "gingival fibromatosis, 1",
            "description": ""
        },
        {
            "id": "MONDO:0007609",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "name": "hereditary gingival fibromatosis, 1",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "fibromatosis, gingival, 2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "GINGF2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "fibromatosis, gingival, 2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "GGF2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "HGF2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "fibromatosis gingival, hereditary, 2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "gingival fibromatosis, 2",
            "description": ""
        },
        {
            "id": "MONDO:0011563",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "name": "hereditary gingival fibromatosis, 2",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "fibromatosis, gingival, 3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "GINGF3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "fibromatosis, gingival, 3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "GGF3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "HGF3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "fibromatosis gingival, hereditary, 3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "gingival fibromatosis, 3",
            "description": ""
        },
        {
            "id": "MONDO:0012378",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "name": "hereditary gingival fibromatosis, 3",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "fibromatosis, gingival, 4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "GINGF4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "fibromatosis, gingival, 4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "GGF4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "HGF4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "fibromatosis gingival, hereditary, 4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "gingival fibromatosis, 4",
            "description": ""
        },
        {
            "id": "MONDO:0012598",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "name": "hereditary gingival fibromatosis, 4",
            "description": ""
        },
        {
            "id": "MIM:135300",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/135300",
            "name": "Fibromatosis, gingival, 1",
            "description": "Fibromatosis, gingival, 1"
        }
    ],
    "children": [
        {
            "id": "DOID:0080280",
            "label": "gingival fibromatosis 5",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0080280",
        "DOID:0060466"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060466",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060466",
            "categories": []
        },
        {
            "id": "MONDO:0007609",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007609",
            "categories": []
        },
        {
            "id": "MONDO:0011563",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011563",
            "categories": []
        },
        {
            "id": "MONDO:0012378",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012378",
            "categories": []
        },
        {
            "id": "MONDO:0012598",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012598",
            "categories": []
        },
        {
            "id": "MIM:135300",
            "database": "MIM",
            "url": "https://www.omim.org/entry/135300",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q62245-1",
            "uniprot_ac": "Q62245",
            "uniprot_id": "SOS1_MOUSE",
            "refseq_ac": "NP_033257",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Son of sevenless homolog 1",
                    "type": "recommended"
                },
                {
                    "name": "SOS-1",
                    "type": "synonym"
                },
                {
                    "name": "guanine nucleotide releasing factor",
                    "type": "synonym"
                },
                {
                    "name": "mSOS-1",
                    "type": "synonym"
                },
                {
                    "name": "ras guanine exchange factor",
                    "type": "synonym"
                },
                {
                    "name": "son of sevenless homolog 1",
                    "type": "synonym"
                },
                {
                    "name": "son-of-sevenless 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sos1",
                    "type": "recommended"
                },
                {
                    "name": "4430401P03Rik",
                    "type": "synonym"
                },
                {
                    "name": "9630010N06",
                    "type": "synonym"
                },
                {
                    "name": "Sos1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q62245-1",
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                {
                    "id": "0060466",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060466"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q07889-1",
            "uniprot_ac": "Q07889",
            "uniprot_id": "SOS1_HUMAN",
            "refseq_ac": "NP_005624",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Son of sevenless homolog 1",
                    "type": "recommended"
                },
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                    "name": "SOS-1",
                    "type": "synonym"
                },
                {
                    "name": "gingival fibromatosis, hereditary, 1",
                    "type": "synonym"
                },
                {
                    "name": "guanine nucleotide exchange factor",
                    "type": "synonym"
                },
                {
                    "name": "son of sevenless homolog 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "son of sevenless homolog 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SOS1",
                    "type": "recommended"
                },
                {
                    "name": "GF1",
                    "type": "synonym"
                },
                {
                    "name": "GGF1",
                    "type": "synonym"
                },
                {
                    "name": "GINGF",
                    "type": "synonym"
                },
                {
                    "name": "HGF",
                    "type": "synonym"
                },
                {
                    "name": "NS4",
                    "type": "synonym"
                },
                {
                    "name": "SOS-1",
                    "type": "synonym"
                },
                {
                    "name": "SOS1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q07889-1",
            "evidence": [
                {
                    "id": "135300",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/135300"
                },
                {
                    "id": "0060466",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060466"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P04821-1",
            "uniprot_ac": "P04821",
            "uniprot_id": "CDC25_YEAST",
            "refseq_ac": "NP_013413",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cell division control protein 25",
                    "type": "recommended"
                },
                {
                    "name": "Ras family guanine nucleotide exchange factor CDC25",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CDC25",
                    "type": "recommended"
                },
                {
                    "name": "CDC25",
                    "type": "synonym"
                },
                {
                    "name": "CTN1",
                    "type": "synonym"
                },
                {
                    "name": "L2142.6",
                    "type": "synonym"
                }
            ],
            "record_id": "P04821-1",
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                {
                    "id": "0060466",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060466"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D4A3T0-1",
            "uniprot_ac": "D4A3T0",
            "uniprot_id": "D4A3T0_RAT",
            "refseq_ac": "NP_001094186",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "SOS Ras/Rac guanine nucleotide exchange factor 1",
                    "type": "synonym"
                },
                {
                    "name": "son of sevenless homolog 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sos1",
                    "type": "recommended"
                },
                {
                    "name": "Sos1",
                    "type": "synonym"
                }
            ],
            "record_id": "D4A3T0-1",
            "evidence": [
                {
                    "id": "0060466",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060466"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P26675-1",
            "uniprot_ac": "P26675",
            "uniprot_id": "SOS_DROME",
            "refseq_ac": "NP_476597",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protein son of sevenless",
                    "type": "recommended"
                },
                {
                    "name": "CG7793-PA",
                    "type": "synonym"
                },
                {
                    "name": "Son of sevenless",
                    "type": "synonym"
                },
                {
                    "name": "Son-of-sevenless",
                    "type": "synonym"
                },
                {
                    "name": "Sos-PA",
                    "type": "synonym"
                },
                {
                    "name": "lethal 24 in the black-reduced region",
                    "type": "synonym"
                },
                {
                    "name": "lethal 25 in the black-reduced region",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sos",
                    "type": "recommended"
                },
                {
                    "name": "2.3",
                    "type": "synonym"
                },
                {
                    "name": "34Ea",
                    "type": "synonym"
                },
                {
                    "name": "BG:DS00941.4",
                    "type": "synonym"
                },
                {
                    "name": "CG7793",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG7793",
                    "type": "synonym"
                },
                {
                    "name": "E(sev)2A",
                    "type": "synonym"
                },
                {
                    "name": "E(var)189",
                    "type": "synonym"
                },
                {
                    "name": "EC2-5",
                    "type": "synonym"
                },
                {
                    "name": "EK2-8",
                    "type": "synonym"
                },
                {
                    "name": "EY2-3",
                    "type": "synonym"
                },
                {
                    "name": "SOS",
                    "type": "synonym"
                },
                {
                    "name": "SoS",
                    "type": "synonym"
                },
                {
                    "name": "Sos1",
                    "type": "synonym"
                },
                {
                    "name": "Sos",
                    "type": "synonym"
                },
                {
                    "name": "Su(tor)2-2",
                    "type": "synonym"
                },
                {
                    "name": "br24",
                    "type": "synonym"
                },
                {
                    "name": "br25",
                    "type": "synonym"
                },
                {
                    "name": "dSos",
                    "type": "synonym"
                },
                {
                    "name": "dme-SOS",
                    "type": "synonym"
                },
                {
                    "name": "l(2)34Ea",
                    "type": "synonym"
                },
                {
                    "name": "l(2)Sos",
                    "type": "synonym"
                },
                {
                    "name": "l(2)br24",
                    "type": "synonym"
                },
                {
                    "name": "l(2)br25",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k05224",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k06321",
                    "type": "synonym"
                },
                {
                    "name": "sos",
                    "type": "synonym"
                }
            ],
            "record_id": "P26675-1",
            "evidence": [
                {
                    "id": "0060466",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060466"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060466"
}