{
    "disease_id": "DOID:0060411",
    "recommended_name": {
        "id": "DOID:0060411",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060411",
        "name": "chromosome 1q21.1 deletion syndrome",
        "description": "A chromosomal deletion syndrome that has_material_basis_in a contiguous deletion of the 1q21.1 region on chromosome 1 and is characterized by an increases the risk of delayed development, intellectual disability, physical abnormalities, and neurological and psychiatric problems."
    },
    "synonyms": [
        {
            "id": "DOID:0060411",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060411",
            "name": "1q21.1 microdeletion syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "chromosome 1q21.1 deletion syndrome",
            "description": "1q21.1 microdeletion syndrome is a newly described recurrent deletion syndrome with variable clinical manifestations but without the clinical picture of thrombocytopenia - absent radius (TAR) syndrome."
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "1q21.1 microdeletion syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "1q21.1 recurrent microdeletion (susceptibility locus for neurodevelopmental disorders)",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "Del(1)(q21)",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "chromosome 1q21.1 deletion syndrome, isolated cases",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "monosomy 1q21.1",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "1q21.1 microdeletion",
            "description": ""
        },
        {
            "id": "MONDO:0012914",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "name": "chromosome 1q21.1 microdeletion syndrome",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060411"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060411",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060411",
            "categories": []
        },
        {
            "id": "MONDO:0012914",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012914",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "G3X946-1",
            "uniprot_ac": "G3X946",
            "uniprot_id": "G3X946_MOUSE",
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            "glycoprotein": "no",
            "species": [
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                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 12",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gm4847",
                    "type": "recommended"
                },
                {
                    "name": "EG226604",
                    "type": "synonym"
                },
                {
                    "name": "Fmo12",
                    "type": "synonym"
                },
                {
                    "name": "Gm4847",
                    "type": "synonym"
                }
            ],
            "record_id": "G3X946-1",
            "evidence": [
                {
                    "id": "0060411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
        },
        {
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            "uniprot_ac": "Q8K2I3",
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                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 2",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.-",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 2",
                    "type": "synonym"
                },
                {
                    "name": "FMO 2",
                    "type": "synonym"
                },
                {
                    "name": "Pulmonary flavin-containing monooxygenase 2",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 2",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 2",
                    "type": "synonym"
                },
                {
                    "name": "pulmonary flavin-containing monooxygenase 2",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Fmo2",
                    "type": "recommended"
                },
                {
                    "name": "2310008D08Rik",
                    "type": "synonym"
                },
                {
                    "name": "2310042I22Rik",
                    "type": "synonym"
                },
                {
                    "name": "Fmo2",
                    "type": "synonym"
                }
            ],
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                    "id": "0060411",
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                }
            ]
        },
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                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase 1",
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                {
                    "name": "1.14.13.148",
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                {
                    "name": "1.14.13.8",
                    "type": "synonym"
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                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 1",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 1",
                    "type": "synonym"
                },
                {
                    "name": "FMO 1",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 1",
                    "type": "synonym"
                },
                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 1",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 1",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "hepatic flavin-containing monooxygenase 1",
                    "type": "synonym"
                },
                {
                    "name": "trimethylamine monooxygenase",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Fmo1",
                    "type": "recommended"
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                {
                    "name": "Fmo-1",
                    "type": "synonym"
                },
                {
                    "name": "Fmo1",
                    "type": "synonym"
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            ],
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                {
                    "id": "0060411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "J3QMN6-1",
            "uniprot_ac": "J3QMN6",
            "uniprot_id": "J3QMN6_MOUSE",
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            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
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                {
                    "name": "flavin containing monooxygenase 6",
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                }
            ],
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                {
                    "name": "Fmo6",
                    "type": "recommended"
                },
                {
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                    "type": "synonym"
                }
            ],
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                    "id": "0060411",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
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        },
        {
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            "uniprot_ac": "P97501",
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            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase 3",
                    "type": "recommended"
                },
                {
                    "name": "1.14.13.148",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.32",
                    "type": "synonym"
                },
                {
                    "name": "1.14.13.8",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "FMO 3",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 3",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline oxidase 3",
                    "type": "synonym"
                },
                {
                    "name": "flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
                },
                {
                    "name": "trimethylamine monooxygenase",
                    "type": "synonym"
                }
            ],
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                    "name": "Fmo3",
                    "type": "recommended"
                },
                {
                    "name": "Fmo3",
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                }
            ],
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                    "id": "0060411",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P97872-1",
            "uniprot_ac": "P97872",
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            "refseq_ac": "NP_001155235",
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                    "name": "Mus musculus",
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                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Flavin-containing monooxygenase 5",
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                {
                    "name": "1.6.3.1",
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                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 5",
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                {
                    "name": "Dimethylaniline oxidase 5",
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                },
                {
                    "name": "FMO 5",
                    "type": "synonym"
                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 5",
                    "type": "synonym"
                },
                {
                    "name": "NADPH oxidase",
                    "type": "synonym"
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                {
                    "name": "NAPDH oxidase",
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                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 5",
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                },
                {
                    "name": "dimethylaniline oxidase 5",
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                {
                    "name": "flavin-containing monooxygenase 5 isoform 1",
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                {
                    "name": "hepatic flavin-containing monooxygenase 5",
                    "type": "synonym"
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                    "name": "Fmo5",
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                    "name": "5033418D19Rik",
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                    "name": "Fmo5",
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                    "id": "0060411",
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                }
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            "uniprot_ac": "P38866",
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                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
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                {
                    "name": "Thiol-specific monooxygenase",
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                {
                    "name": "Flavin-dependent monooxygenase",
                    "type": "synonym"
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                {
                    "name": "N,N-dimethylaniline monooxygenase",
                    "type": "synonym"
                }
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                    "name": "FMO1",
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                    "id": "0060411",
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                }
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            "uniprot_ac": "D4ADX9",
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                    "name": "Rattus norvegicus",
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                    "glygen_name": "Rat",
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                }
            ],
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                {
                    "name": "Sulfotransferase",
                    "type": "recommended"
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                {
                    "name": "2.8.2.-",
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                {
                    "name": "sulfotransferase family 5A, member 1",
                    "type": "synonym"
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                    "name": "Sult5a1",
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                    "name": "Sult5a1",
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                    "id": "0060411",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
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            "uniprot_canonical_ac": "D3ZD07-1",
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                }
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                    "name": "Flavin-containing monooxygenase",
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                    "name": "1.-.-.-",
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                {
                    "name": "flavin containing monooxygenase 9 pseudogene",
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                {
                    "name": "flavin containing monooxygenase 9",
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            ],
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                    "name": "Fmo9",
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                    "name": "Fmo9p",
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                    "name": "Fmo9",
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                    "id": "0060411",
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                }
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                    "name": "Rattus norvegicus",
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                }
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                    "name": "Flavin-containing monooxygenase",
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                    "name": "1.-.-.-",
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                {
                    "name": "flavin-containing monooxygenase 5",
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                    "name": "Fmol",
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                    "name": "Fmol",
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                    "name": "LOC685351",
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                    "id": "0060411",
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                }
            ]
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                    "name": "Rattus norvegicus",
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                    "common_name": "Rat",
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                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
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                {
                    "name": "flavin-containing monooxygenase 5",
                    "type": "synonym"
                }
            ],
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                    "name": "Fmo13",
                    "type": "recommended"
                },
                {
                    "name": "Fmo13",
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                }
            ],
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                {
                    "id": "0060411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "M0R553-1",
            "uniprot_ac": "M0R553",
            "uniprot_id": "M0R553_RAT",
            "refseq_ac": "XP_006250268",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase",
                    "type": "recommended"
                },
                {
                    "name": "1.-.-.-",
                    "type": "synonym"
                },
                {
                    "name": "putative dimethylaniline monooxygenase [N-oxide-forming] 6",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Fmo6",
                    "type": "recommended"
                },
                {
                    "name": "Fmo6",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0060411",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060411"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8K4C0-1",
            "uniprot_ac": "Q8K4C0",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Flavin-containing monooxygenase 5",
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                },
                {
                    "name": "1.14.13.8",
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                {
                    "name": "1.6.3.1",
                    "type": "synonym"
                },
                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 5",
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                {
                    "name": "Dimethylaniline oxidase 5",
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                },
                {
                    "name": "FMO 5",
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                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 5",
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                {
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                {
                    "name": "NAPDH oxidase",
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                {
                    "name": "flavin-containing monooxygenase 5",
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                }
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                    "id": "0060411",
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            ],
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                {
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                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 4",
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                {
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                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 4",
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                {
                    "name": "dimethylaniline oxidase 4",
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                {
                    "name": "flavin containing monooxygenase 4",
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                {
                    "name": "hepatic flavin-containing monooxygenase 4",
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                }
            ],
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                    "id": "0060411",
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                    "name": "1.14.13.148",
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                    "name": "1.14.13.32",
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                {
                    "name": "1.14.13.8",
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                {
                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 3",
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                },
                {
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                },
                {
                    "name": "FMO 3",
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                },
                {
                    "name": "Hepatic flavin-containing monooxygenase 3",
                    "type": "synonym"
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                {
                    "name": "Trimethylamine monooxygenase",
                    "type": "synonym"
                },
                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 3",
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                },
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                {
                    "name": "flavin containing monooxygenase 3",
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                    "name": "flavin-containing monooxygenase 3",
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                },
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                    "name": "hepatic flavin-containing monooxygenase 3",
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                {
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                }
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                    "id": "0060411",
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                }
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                    "name": "Dimethylaniline monooxygenase [N-oxide-forming] 1",
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                },
                {
                    "name": "Dimethylaniline oxidase 1",
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                {
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                {
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                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 1",
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                {
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                    "name": "flavin-containing monooxygenase 1",
                    "type": "synonym"
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                {
                    "name": "hepatic flavin-containing monooxygenase 1",
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                }
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                    "name": "Fmo1",
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                    "name": "RFMO1A",
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                }
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                    "id": "0060411",
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                {
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                {
                    "name": "Pulmonary flavin-containing monooxygenase 2",
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                {
                    "name": "dimethylaniline monooxygenase [N-oxide-forming] 2",
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                {
                    "name": "flavin containing monooxygenase 2",
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                    "name": "pulmonary flavin-containing monooxygenase 2",
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                    "id": "0060411",
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                    "name": "Dmel\\CG2041",
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                {
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                    "name": "FMO 4",
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                {
                    "name": "Hepatic flavin-containing monooxygenase 4",
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                    "name": "Pulmonary flavin-containing monooxygenase 2",
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    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060411"
}