{
    "disease_id": "DOID:0060368",
    "recommended_name": {
        "id": "DOID:0060368",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060368",
        "name": "Parkinson's disease 2",
        "description": "An early-onset Parkinson's disease that has_material_basis_in mutation in the parkin gene on chromosome 6q25.2-q27."
    },
    "synonyms": [
        {
            "id": "DOID:0060368",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060368",
            "name": "autosomal recessive juvenile Parkinson disease 2",
            "description": ""
        },
        {
            "id": "DOID:0060368",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060368",
            "name": "autosomal recessive juvenile Parkinson's disease 2",
            "description": ""
        },
        {
            "id": "DOID:0060368",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060368",
            "name": "Parkinson disease juvenile type 2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "autosomal recessive juvenile Parkinson disease 2",
            "description": "A group of disorders which feature impaired motor control characterized by bradykinesia, muscle rigidity; tremor; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see Parkinson disease), secondary parkinsonism (see Parkinson disease, secondary) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the basal ganglia."
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "PRKN young-onset Parkinson disease",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "Parkinson disease, juvenile, type 2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "autosomal recessive juvenile Parkinson disease 2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "autosomal recessive juvenile Parkinson disease type 2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "young-onset Parkinson disease caused by mutation in PRKN",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "JP",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "PARK2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "PDJ",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "Parkinson disease 2",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "Parkinson disease 2, autosomal recessive juvenile",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "Parkinson disease autosomal recessive, early onset",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "Parkinsonism, early onset, with diurnal fluctuation",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "autosomal recessive juvenile Parkinson disease",
            "description": ""
        },
        {
            "id": "MONDO:0010820",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "name": "juvenile parkinsonism",
            "description": ""
        },
        {
            "id": "MIM:600116",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/600116",
            "name": "Parkinson disease 2",
            "description": "Parkinson disease 2"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060368"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060368",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060368",
            "categories": []
        },
        {
            "id": "MONDO:0010820",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010820",
            "categories": []
        },
        {
            "id": "MIM:600116",
            "database": "MIM",
            "url": "https://www.omim.org/entry/600116",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB13ABF7-1",
            "uniprot_ac": "A0AB13ABF7",
            "uniprot_id": "A0AB13ABF7_DANRE",
            "refseq_ac": "NP_001410636",
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            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "recommended"
                },
                {
                    "name": "2.3.2.31",
                    "type": "synonym"
                },
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson disease (autosomal recessive, juvenile) 2, parkin",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "prkn",
                    "type": "recommended"
                },
                {
                    "name": "park2",
                    "type": "synonym"
                },
                {
                    "name": "prkn",
                    "type": "synonym"
                },
                {
                    "name": "si:ch211-123f21.1",
                    "type": "synonym"
                },
                {
                    "name": "zgc:112390",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB13ABF7-1",
            "evidence": [
                {
                    "id": "0060368",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060368"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9WVS6-1",
            "uniprot_ac": "Q9WVS6",
            "uniprot_id": "PRKN_MOUSE",
            "refseq_ac": "NP_001304655",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "recommended"
                },
                {
                    "name": "2.3.2.31",
                    "type": "synonym"
                },
                {
                    "name": "E3 ubiquitin-protein ligase parkin isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "synonym"
                },
                {
                    "name": "Parkin RBR E3 ubiquitin-protein ligase",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson disease (autosomal recessive, juvenile) 2, parkin",
                    "type": "synonym"
                },
                {
                    "name": "parkin protein",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Prkn",
                    "type": "recommended"
                },
                {
                    "name": "Park2",
                    "type": "synonym"
                },
                {
                    "name": "Prkn",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9WVS6-1",
            "evidence": [
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                    "id": "0060368",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060368"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O60260-1",
            "uniprot_ac": "O60260",
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            "refseq_ac": "NP_004553",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "recommended"
                },
                {
                    "name": "2.3.2.31",
                    "type": "synonym"
                },
                {
                    "name": "E3 ubiquitin-protein ligase parkin isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "Parkin RBR E3 ubiquitin-protein ligase",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson disease (autosomal recessive, juvenile) 2, parkin",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson disease protein 2",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson juvenile disease protein 2",
                    "type": "synonym"
                },
                {
                    "name": "Parkin",
                    "type": "synonym"
                },
                {
                    "name": "parkinson juvenile disease protein 2",
                    "type": "synonym"
                },
                {
                    "name": "parkinson protein 2 E3 ubiquitin protein ligase",
                    "type": "synonym"
                },
                {
                    "name": "parkinson protein 2, E3 ubiquitin protein ligase (parkin)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PRKN",
                    "type": "recommended"
                },
                {
                    "name": "AR-JP",
                    "type": "synonym"
                },
                {
                    "name": "LPRS2",
                    "type": "synonym"
                },
                {
                    "name": "PARK2",
                    "type": "synonym"
                },
                {
                    "name": "PDJ",
                    "type": "synonym"
                },
                {
                    "name": "PRKN",
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                }
            ],
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                    "id": "600116",
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                {
                    "id": "0060368",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060368"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9JK66-1",
            "uniprot_ac": "Q9JK66",
            "uniprot_id": "PRKN_RAT",
            "refseq_ac": "NP_064478",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "recommended"
                },
                {
                    "name": "2.3.2.31",
                    "type": "synonym"
                },
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "synonym"
                },
                {
                    "name": "Parkin RBR E3 ubiquitin-protein ligase",
                    "type": "synonym"
                },
                {
                    "name": "Parkinson disease (autosomal recessive, juvenile) 2, parkin",
                    "type": "synonym"
                },
                {
                    "name": "parkin RBR E3 ubiquitin protein ligase 2",
                    "type": "synonym"
                },
                {
                    "name": "parkin variant SV5DEL",
                    "type": "synonym"
                },
                {
                    "name": "parkinson protein 2, E3 ubiquitin protein ligase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Prkn",
                    "type": "recommended"
                },
                {
                    "name": "AABR07001519.1",
                    "type": "synonym"
                },
                {
                    "name": "Park2",
                    "type": "synonym"
                },
                {
                    "name": "Park",
                    "type": "synonym"
                },
                {
                    "name": "Prkn",
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                }
            ],
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                    "id": "0060368",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0060368"
                }
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            "uniprot_canonical_ac": "Q7KTX7-1",
            "uniprot_ac": "Q7KTX7",
            "uniprot_id": "PRKN_DROME",
            "refseq_ac": "NP_730600",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "E3 ubiquitin-protein ligase parkin",
                    "type": "recommended"
                },
                {
                    "name": "2.3.2.31",
                    "type": "synonym"
                },
                {
                    "name": "CG10523-PB",
                    "type": "synonym"
                },
                {
                    "name": "D-parkin",
                    "type": "synonym"
                },
                {
                    "name": "dparkin",
                    "type": "synonym"
                },
                {
                    "name": "ortholog of PRKN",
                    "type": "synonym"
                },
                {
                    "name": "park-PB",
                    "type": "synonym"
                },
                {
                    "name": "parkin F",
                    "type": "synonym"
                },
                {
                    "name": "parkin, isoform B",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "park",
                    "type": "recommended"
                },
                {
                    "name": "AAN12155.1",
                    "type": "synonym"
                },
                {
                    "name": "CG10523",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG10523",
                    "type": "synonym"
                },
                {
                    "name": "Dpark",
                    "type": "synonym"
                },
                {
                    "name": "PARK2",
                    "type": "synonym"
                },
                {
                    "name": "PARKIN",
                    "type": "synonym"
                },
                {
                    "name": "PARK",
                    "type": "synonym"
                },
                {
                    "name": "PK",
                    "type": "synonym"
                },
                {
                    "name": "Parkin",
                    "type": "synonym"
                },
                {
                    "name": "Park",
                    "type": "synonym"
                },
                {
                    "name": "SD01679",
                    "type": "synonym"
                },
                {
                    "name": "dPARKIN",
                    "type": "synonym"
                },
                {
                    "name": "dParkin",
                    "type": "synonym"
                },
                {
                    "name": "dparkin",
                    "type": "synonym"
                },
                {
                    "name": "dpark",
                    "type": "synonym"
                },
                {
                    "name": "dpk",
                    "type": "synonym"
                },
                {
                    "name": "park1",
                    "type": "synonym"
                },
                {
                    "name": "parkin",
                    "type": "synonym"
                },
                {
                    "name": "park",
                    "type": "synonym"
                },
                {
                    "name": "pk",
                    "type": "synonym"
                },
                {
                    "name": "prkn",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7KTX7-1",
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                {
                    "id": "0060368",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060368"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060368"
}