{
    "disease_id": "DOID:0060075",
    "recommended_name": {
        "id": "DOID:0060075",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060075",
        "name": "estrogen-receptor positive breast cancer",
        "description": "A breast cancer that is characterized by the presence of estrogen receptors."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
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    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060075",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060075",
            "categories": []
        }
    ],
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            "uniprot_ac": "F1QAD7",
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                }
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Disintegrin and metalloproteinase domain-containing protein 28",
                    "type": "recommended"
                },
                {
                    "name": "3.4.24.-",
                    "type": "synonym"
                },
                {
                    "name": "ADAM 28",
                    "type": "synonym"
                },
                {
                    "name": "Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II",
                    "type": "synonym"
                },
                {
                    "name": "MDC-L",
                    "type": "synonym"
                },
                {
                    "name": "Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L",
                    "type": "synonym"
                },
                {
                    "name": "disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "disintegrin and metalloproteinase domain-containing protein 28",
                    "type": "synonym"
                },
                {
                    "name": "eMDC II",
                    "type": "synonym"
                },
                {
                    "name": "epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II",
                    "type": "synonym"
                },
                {
                    "name": "epididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein II",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "metalloproteinase-like, disintegrin-like, and cysteine-rich protein-L",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ADAM28",
                    "type": "recommended"
                },
                {
                    "name": "ADAM 28",
                    "type": "synonym"
                },
                {
                    "name": "ADAM23",
                    "type": "synonym"
                },
                {
                    "name": "ADAM28",
                    "type": "synonym"
                },
                {
                    "name": "MDC-L",
                    "type": "synonym"
                },
                {
                    "name": "MDCL",
                    "type": "synonym"
                },
                {
                    "name": "eMDC II",
                    "type": "synonym"
                },
                {
                    "name": "eMDCII",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9UKQ2-1",
            "evidence": [
                {
                    "id": "0060075",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060075"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P42336-1",
            "uniprot_ac": "P42336",
            "uniprot_id": "PK3CA_HUMAN",
            "refseq_ac": "NP_006209",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
                    "type": "recommended"
                },
                {
                    "name": "2.7.1.137",
                    "type": "synonym"
                },
                {
                    "name": "2.7.1.153",
                    "type": "synonym"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "PI3-kinase p110 subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "PI3-kinase subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "PI3K-alpha",
                    "type": "synonym"
                },
                {
                    "name": "PI3Kalpha",
                    "type": "synonym"
                },
                {
                    "name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "Phosphoinositide 3-kinase alpha",
                    "type": "synonym"
                },
                {
                    "name": "Phosphoinositide-3-kinase catalytic alpha polypeptide",
                    "type": "synonym"
                },
                {
                    "name": "PtdIns-3-kinase subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "PtdIns-3-kinase subunit p110-alpha",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine protein kinase PIK3CA",
                    "type": "synonym"
                },
                {
                    "name": "mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "p110alpha",
                    "type": "synonym"
                },
                {
                    "name": "phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha",
                    "type": "synonym"
                },
                {
                    "name": "phosphatidylinositol 3-kinase, catalytic, alpha polypeptide",
                    "type": "synonym"
                },
                {
                    "name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform",
                    "type": "synonym"
                },
                {
                    "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha",
                    "type": "synonym"
                },
                {
                    "name": "phosphoinositide 3-kinase alpha",
                    "type": "synonym"
                },
                {
                    "name": "phosphoinositide-3-kinase, catalytic, alpha polypeptide",
                    "type": "synonym"
                },
                {
                    "name": "ptdIns-3-kinase subunit p110-alpha",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine protein kinase PIK3CA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PIK3CA",
                    "type": "recommended"
                },
                {
                    "name": "CCM4",
                    "type": "synonym"
                },
                {
                    "name": "CLAPO",
                    "type": "synonym"
                },
                {
                    "name": "CLOVE",
                    "type": "synonym"
                },
                {
                    "name": "CWS5",
                    "type": "synonym"
                },
                {
                    "name": "HMH",
                    "type": "synonym"
                },
                {
                    "name": "MCAP",
                    "type": "synonym"
                },
                {
                    "name": "MCMTC",
                    "type": "synonym"
                },
                {
                    "name": "MCM",
                    "type": "synonym"
                },
                {
                    "name": "PI3K-alpha",
                    "type": "synonym"
                },
                {
                    "name": "PI3K",
                    "type": "synonym"
                },
                {
                    "name": "PIK3CA",
                    "type": "synonym"
                },
                {
                    "name": "p110-alpha",
                    "type": "synonym"
                }
            ],
            "record_id": "P42336-1",
            "evidence": [
                {
                    "id": "0060075",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060075"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060075"
}