{
    "disease_id": "DOID:0050852",
    "recommended_name": {
        "id": "DOID:0050852",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050852",
        "name": "limb ischemia",
        "description": "An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0050852"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050852",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050852",
            "categories": []
        }
    ],
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                {
                    "name": "2.3.3.16",
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                },
                {
                    "name": "CG3861-PA",
                    "type": "synonym"
                },
                {
                    "name": "Protein knockdown",
                    "type": "synonym"
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                {
                    "name": "citrate synthase",
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                {
                    "name": "kdn-PA",
                    "type": "synonym"
                },
                {
                    "name": "knockdown, isoform A",
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                {
                    "name": "lethal (1) G0030",
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                    "name": "Cs1",
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                {
                    "name": "BEST:GM01832",
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                    "name": "CG 3861",
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                    "name": "CG3861",
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                {
                    "name": "CS",
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                {
                    "name": "Csyn",
                    "type": "synonym"
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                {
                    "name": "Dmel\\CG3861",
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                    "name": "Kdn",
                    "type": "synonym"
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                    "name": "csyn",
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                {
                    "name": "kdn",
                    "type": "synonym"
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                {
                    "name": "l (1) G0030",
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                {
                    "name": "l(1)G0030",
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                {
                    "name": "l(1)G0033",
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                {
                    "name": "l(1)G0159",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050852",
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            ]
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            "uniprot_canonical_ac": "P10041-1",
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                {
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            ],
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                {
                    "name": "Neurogenic locus protein delta",
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                {
                    "name": "CG3619-PC",
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                {
                    "name": "Delta-PC",
                    "type": "synonym"
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                {
                    "name": "complementation group 1",
                    "type": "synonym"
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                {
                    "name": "delta, isoform C",
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                {
                    "name": "delta",
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                {
                    "name": "overflow",
                    "type": "synonym"
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            ],
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                {
                    "name": "Delta",
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                {
                    "name": "03",
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                {
                    "name": "0495/20",
                    "type": "synonym"
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                {
                    "name": "04",
                    "type": "synonym"
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                {
                    "name": "0926/11",
                    "type": "synonym"
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                {
                    "name": "09",
                    "type": "synonym"
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                {
                    "name": "1053/14",
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                {
                    "name": "1119/09",
                    "type": "synonym"
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                {
                    "name": "11",
                    "type": "synonym"
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                {
                    "name": "1304/03",
                    "type": "synonym"
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                {
                    "name": "1423/11",
                    "type": "synonym"
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                {
                    "name": "1440/11",
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                {
                    "name": "1485/04",
                    "type": "synonym"
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                {
                    "name": "14",
                    "type": "synonym"
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                {
                    "name": "20",
                    "type": "synonym"
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                {
                    "name": "C1",
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                {
                    "name": "CG3619",
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                {
                    "name": "CT12133",
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                {
                    "name": "D1",
                    "type": "synonym"
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                {
                    "name": "DL",
                    "type": "synonym"
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                {
                    "name": "Deltal",
                    "type": "synonym"
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                {
                    "name": "Delta",
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                {
                    "name": "Dl",
                    "type": "synonym"
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                {
                    "name": "Dmel\\CG3619",
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                {
                    "name": "Dmel_CG3619",
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                {
                    "name": "E(ls)2",
                    "type": "synonym"
                },
                {
                    "name": "EC3-5",
                    "type": "synonym"
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                {
                    "name": "anon-WO0118547.269",
                    "type": "synonym"
                },
                {
                    "name": "delta D1",
                    "type": "synonym"
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                {
                    "name": "delta",
                    "type": "synonym"
                },
                {
                    "name": "dmDelta",
                    "type": "synonym"
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                {
                    "name": "l(3)05151",
                    "type": "synonym"
                },
                {
                    "name": "l(3)92Ab",
                    "type": "synonym"
                },
                {
                    "name": "l(3)j8C3",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050852",
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            ]
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                }
            ],
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                    "name": "Fibroblast growth factor receptor homolog 1",
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                    "name": "2.7.10.1",
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                {
                    "name": "CG7223-PB",
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                {
                    "name": "DmHD-38",
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                    "name": "FGF receptor",
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                    "name": "Protein heartless",
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                {
                    "name": "Tyrosine kinase 1",
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                    "name": "dTk1",
                    "type": "synonym"
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                {
                    "name": "fibroblast growth factor receptor 1",
                    "type": "synonym"
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                {
                    "name": "fibroblast growth factor receptor",
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                {
                    "name": "heartless, isoform B",
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                {
                    "name": "heartless",
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                {
                    "name": "htl-PB",
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                }
            ],
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                {
                    "name": "htl",
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                    "name": "CG7223",
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                    "name": "CT22273",
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                },
                {
                    "name": "CT39172",
                    "type": "synonym"
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                {
                    "name": "DFGF-R1",
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                {
                    "name": "DFGF-R2",
                    "type": "synonym"
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                {
                    "name": "DFR-1",
                    "type": "synonym"
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                {
                    "name": "DFR1/DFGF-R2",
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                },
                {
                    "name": "DFR1",
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                {
                    "name": "DPR3",
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                {
                    "name": "DTRK(FR1)",
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                {
                    "name": "Dfr-1",
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                    "name": "Dfr1",
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                    "name": "DmHD-38",
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                    "name": "Dmel\\CG7223",
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                    "name": "Dtk1",
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                    "name": "EMS2",
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                {
                    "name": "FGF-R2",
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                {
                    "name": "FGFR2",
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                    "name": "FGFR",
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                    "name": "FR1",
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                {
                    "name": "Fr1",
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                    "name": "HD-38",
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                {
                    "name": "HTL/FGFR1",
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                {
                    "name": "Htl",
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                {
                    "name": "Tk1",
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                    "name": "dtk1",
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                {
                    "name": "htl",
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                {
                    "name": "i100",
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                {
                    "name": "i150",
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                {
                    "name": "i79",
                    "type": "synonym"
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                {
                    "name": "j372",
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            ],
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                    "id": "0050852",
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                    "name": "CG32134-PB",
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                    "name": "FGF receptor",
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                    "name": "FGFR",
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                    "name": "Fibroblast-growth-factor-receptor",
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                    "name": "Protein breathless",
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                    "name": "Tyrosine kinase 2",
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                    "name": "Tyrosine kinase receptor HD-311",
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                    "name": "breathless, isoform B",
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                    "name": "breathless",
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                    "name": "btl-PB",
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                    "name": "dFGF-R1",
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                    "name": "dTk2",
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                {
                    "name": "devenir",
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                {
                    "name": "fibrobast growth factor receptor",
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                {
                    "name": "fibroblast growth factor receptor 1",
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                },
                {
                    "name": "fibroblast growth factor receptor",
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                {
                    "name": "lethal (3) j2E11",
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                {
                    "name": "no terminal cell clones-L",
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                    "name": "btl",
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                    "name": "0844/01",
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                    "name": "CG32134",
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                    "name": "CG6714",
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                    "name": "CT20816",
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                    "name": "FGFR",
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                    "name": "FR2",
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                    "name": "Fgf-r",
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                    "name": "Fgfr",
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                    "name": "HD-311",
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                    "name": "Tk2",
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                    "name": "btl",
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                    "name": "dFGFR",
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                    "name": "dev",
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                    "name": "dtk2",
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                    "name": "fgf-r",
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                {
                    "name": "l(3)00208",
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                {
                    "name": "l(3)j2E11",
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                    "id": "0050852",
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                    "name": "7951",
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                    "name": "CG31031",
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                    "name": "CG45051",
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                    "name": "CG7951",
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                    "name": "Dmel\\CG45051",
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                    "name": "Dmel_CG45051",
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                    "name": "HIF alpha",
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                    "name": "HIF-1alpha",
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                    "name": "HIF-1a",
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                    "name": "HIF-1",
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                    "name": "HIF-alpha/sima",
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                    "name": "HIF1A",
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                    "name": "HIF1alpha",
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                    "name": "HIF1",
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                    "name": "HIFalpha",
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                    "name": "Hif-1A",
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                {
                    "name": "Hif1alpha",
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                    "name": "Hifalpha",
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                    "name": "SIMA",
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                    "name": "Sima",
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                    "name": "bHLHe56",
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                    "name": "dHIF-1alpha",
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                    "name": "dHIF-alpha",
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                    "name": "hif",
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                    "name": "l(3)j11B7",
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                    "name": "sima",
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                    "id": "0050852",
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            "uniprot_canonical_ac": "O00299-1",
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                    "name": "Chloride intracellular channel protein 1",
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                    "name": "Chloride channel ABP",
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                    "name": "Glutaredoxin-like oxidoreductase CLIC1",
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                {
                    "name": "Glutathione-dependent dehydroascorbate reductase CLIC1",
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                },
                {
                    "name": "NCC27",
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                {
                    "name": "Nuclear chloride ion channel 27",
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                {
                    "name": "RNCC protein",
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                    "name": "Regulatory nuclear chloride ion channel protein",
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                    "name": "chloride channel ABP",
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                {
                    "name": "glutaredoxin-like oxidoreductase CLIC1",
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                {
                    "name": "glutathione-dependent dehydroascorbate reductase CLIC1",
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                {
                    "name": "hRNCC",
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                {
                    "name": "nuclear chloride ion channel 27",
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                {
                    "name": "nuclear chloride ion channel protein",
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                {
                    "name": "p64CLCP",
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                {
                    "name": "regulatory nuclear chloride ion channel protein",
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                    "name": "CLIC1",
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                    "name": "CL1C1",
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                {
                    "name": "CLCNL1",
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                {
                    "name": "CLIC1",
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                {
                    "name": "G6",
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                {
                    "name": "NCC27",
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                    "id": "0050852",
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                }
            ]
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        {
            "uniprot_canonical_ac": "Q03468-1",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "DNA excision repair protein ERCC-6",
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                    "name": "3.6.4.-",
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                {
                    "name": "ATP-dependent helicase ERCC6",
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                {
                    "name": "Chimeric CSB-PGBD3 protein",
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                {
                    "name": "Homo sapiens",
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                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "ETS translocation variant 2",
                    "type": "recommended"
                },
                {
                    "name": "ETS translocation variant 2 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "Ets-related protein 71",
                    "type": "synonym"
                },
                {
                    "name": "ets variant gene 2",
                    "type": "synonym"
                },
                {
                    "name": "ets-related protein 71",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ETV2",
                    "type": "recommended"
                },
                {
                    "name": "ER71",
                    "type": "synonym"
                },
                {
                    "name": "ETSRP71",
                    "type": "synonym"
                },
                {
                    "name": "ETV2",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050852",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q16647-1",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Prostacyclin synthase",
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                },
                {
                    "name": "4.2.1.152",
                    "type": "synonym"
                },
                {
                    "name": "5.3.99.4",
                    "type": "synonym"
                },
                {
                    "name": "Hydroperoxy icosatetraenoate dehydratase",
                    "type": "synonym"
                },
                {
                    "name": "Prostaglandin I2 synthase",
                    "type": "synonym"
                },
                {
                    "name": "cytochrome P450, family 8, subfamily A, polypeptide 1",
                    "type": "synonym"
                },
                {
                    "name": "hydroperoxy icosatetraenoate dehydratase",
                    "type": "synonym"
                },
                {
                    "name": "prostacyclin synthase",
                    "type": "synonym"
                },
                {
                    "name": "prostaglandin I2 (prostacyclin) synthase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "PTGIS",
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                },
                {
                    "name": "CYP8A1",
                    "type": "synonym"
                },
                {
                    "name": "CYP8",
                    "type": "synonym"
                },
                {
                    "name": "PGIS",
                    "type": "synonym"
                },
                {
                    "name": "PTGIS",
                    "type": "synonym"
                },
                {
                    "name": "PTGI",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050852",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "P29474-1",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Nitric oxide synthase 3",
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                {
                    "name": "1.14.13.39",
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                },
                {
                    "name": "Constitutive NOS",
                    "type": "synonym"
                },
                {
                    "name": "EC-NOS",
                    "type": "synonym"
                },
                {
                    "name": "Endothelial NOS",
                    "type": "synonym"
                },
                {
                    "name": "NOS type III",
                    "type": "synonym"
                },
                {
                    "name": "NOSIII",
                    "type": "synonym"
                },
                {
                    "name": "Nitric oxide synthase, endothelial",
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                },
                {
                    "name": "cNOS",
                    "type": "synonym"
                },
                {
                    "name": "constitutive NOS",
                    "type": "synonym"
                },
                {
                    "name": "eNOS",
                    "type": "synonym"
                },
                {
                    "name": "endothelial NOS",
                    "type": "synonym"
                },
                {
                    "name": "nitric oxide synthase 3 (endothelial cell)",
                    "type": "synonym"
                },
                {
                    "name": "nitric oxide synthase 3 isoform 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NOS3",
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                {
                    "name": "EC-NOS",
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                },
                {
                    "name": "ECNOS",
                    "type": "synonym"
                },
                {
                    "name": "MYMY8",
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                },
                {
                    "name": "NOS3",
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                },
                {
                    "name": "NOSIII",
                    "type": "synonym"
                },
                {
                    "name": "cNOS",
                    "type": "synonym"
                },
                {
                    "name": "eNOS",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050852",
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            ]
        },
        {
            "uniprot_canonical_ac": "P25098-1",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "G protein-coupled receptor kinase 2",
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                {
                    "name": "2.7.11.15",
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                },
                {
                    "name": "2.7.11.16",
                    "type": "synonym"
                },
                {
                    "name": "Beta-ARK-1",
                    "type": "synonym"
                },
                {
                    "name": "Beta-adrenergic receptor kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "adrenergic beta receptor kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "beta-ARK-1",
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                },
                {
                    "name": "beta-adrenergic receptor kinase 1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "GRK2",
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                {
                    "name": "ADRBK1",
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                },
                {
                    "name": "BARK1",
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                },
                {
                    "name": "BARK",
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                },
                {
                    "name": "BETA-ARK1",
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                },
                {
                    "name": "GRK2",
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                }
            ],
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                    "id": "0050852",
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            ]
        },
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                    "name": "Homo sapiens",
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            ],
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                {
                    "name": "Heme oxygenase 1",
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                {
                    "name": "1.14.14.18",
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                },
                {
                    "name": "HO-1",
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                {
                    "name": "heat shock protein, 32-kD",
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                },
                {
                    "name": "heme oxygenase (decycling) 1",
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                {
                    "name": "heme oxygenase 1",
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            ],
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                    "name": "HMOX1",
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                    "name": "HMOX1D",
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                {
                    "name": "HMOX1",
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                {
                    "name": "HO-1",
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                {
                    "name": "HO1",
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                {
                    "name": "HO",
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                {
                    "name": "HSP32",
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                },
                {
                    "name": "bK286B10",
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            ],
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                    "id": "0050852",
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            ]
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            "uniprot_canonical_ac": "O75390-1",
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            ],
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                {
                    "name": "Citrate synthase, mitochondrial",
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                {
                    "name": "2.3.3.1",
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                {
                    "name": "Citrate (Si)-synthase",
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                {
                    "name": "citrate (Si)-synthase",
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                {
                    "name": "citrate synthase, mitochondrial precursor",
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                {
                    "name": "citrate synthase, mitochondrial",
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            ],
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                {
                    "name": "CS",
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                {
                    "name": "CS",
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                    "id": "0050852",
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            ]
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            ],
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                    "name": "Vascular endothelial growth factor A, long form",
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                    "name": "L-VEGF",
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                    "name": "VPF",
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                    "name": "vascular endothelial growth factor A, long form isoform c",
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                {
                    "name": "vascular endothelial growth factor A, long form",
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                {
                    "name": "vascular endothelial growth factor A121",
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                {
                    "name": "vascular endothelial growth factor A165",
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                {
                    "name": "vascular permeability factor",
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                    "name": "VEGFA",
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                    "name": "MVCD1",
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                    "name": "VEGF",
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                    "name": "FGFR1/PLAG1 fusion",
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                    "name": "FLT-2",
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                    "name": "FMS-like tyrosine kinase 2",
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                {
                    "name": "basic fibroblast growth factor receptor 1",
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                    "name": "fibroblast growth factor receptor 1 isoform 10 precursor",
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                    "name": "fms-related tyrosine kinase 2",
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                {
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                    "name": "hydroxyaryl-protein kinase",
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                    "name": "BFGFR",
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                    "name": "CD331",
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                    "name": "ECCL",
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                    "name": "FGFR1",
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                    "name": "HRTFDS",
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                    "name": "KAL2",
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                    "name": "OGD",
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                {
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                {
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                {
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                    "name": "HIF1A",
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                {
                    "name": "HIF1",
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                {
                    "name": "MOP1",
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                    "name": "bHLHe78",
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    ],
    "glycans": [],
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    "association_flag": "1000",
    "record_id": "doid.0050852"
}