{
    "disease_id": "DOID:0050824",
    "recommended_name": {
        "id": "DOID:0050824",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050824",
        "name": "sinoatrial node disease",
        "description": "A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm."
    },
    "synonyms": [
        {
            "id": "DOID:0050824",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050824",
            "name": "SA node",
            "description": ""
        },
        {
            "id": "DOID:0050824",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050824",
            "name": "sinuatrial node",
            "description": ""
        }
    ],
    "children": [
        {
            "id": "DOID:13884",
            "label": "sick sinus syndrome",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:13884",
        "DOID:0050824"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050824",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050824",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M9QGU1-1",
            "uniprot_ac": "A0A8M9QGU1",
            "uniprot_id": "A0A8M9QGU1_DANRE",
            "refseq_ac": "XP_021333150",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ankyrin-2b isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-2b isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ank2b",
                    "type": "recommended"
                },
                {
                    "name": "ank2b",
                    "type": "synonym"
                },
                {
                    "name": "ank2",
                    "type": "synonym"
                },
                {
                    "name": "zgc:101738",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M9QGU1-1",
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M9QDK6-1",
            "uniprot_ac": "A0A8M9QDK6",
            "uniprot_id": "A0A8M9QDK6_DANRE",
            "refseq_ac": "XP_021331695",
            "glycoprotein": "yes",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Ankyrin-2 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-2 isoform X1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "ank2a",
                    "type": "recommended"
                },
                {
                    "name": "ank2a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M9QDK6-1",
            "evidence": [
                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8C8R3-1",
            "uniprot_ac": "Q8C8R3",
            "uniprot_id": "ANK2_MOUSE",
            "refseq_ac": "NP_001029340",
            "glycoprotein": "yes",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ankyrin-2",
                    "type": "recommended"
                },
                {
                    "name": "ANK-2",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin-B",
                    "type": "synonym"
                },
                {
                    "name": "Brain ankyrin",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-2 isoform 3",
                    "type": "synonym"
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                {
                    "name": "ankyrin-B",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Ank2",
                    "type": "recommended"
                },
                {
                    "name": "100043364",
                    "type": "synonym"
                },
                {
                    "name": "Ank-2",
                    "type": "synonym"
                },
                {
                    "name": "Ank2",
                    "type": "synonym"
                },
                {
                    "name": "AnkB",
                    "type": "synonym"
                },
                {
                    "name": "Gm4392",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8C8R3-1",
            "evidence": [
                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q923J1-1",
            "uniprot_ac": "Q923J1",
            "uniprot_id": "TRPM7_MOUSE",
            "refseq_ac": "NP_001157797",
            "glycoprotein": "no",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Transient receptor potential cation channel subfamily M member 7",
                    "type": "recommended"
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                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "Channel-kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC7",
                    "type": "synonym"
                },
                {
                    "name": "Long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "TRP-PLIK",
                    "type": "synonym"
                },
                {
                    "name": "Transient receptor potential-phospholipase C-interacting kinase",
                    "type": "synonym"
                },
                {
                    "name": "channel-kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential M7",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential cation channel subfamily M member 7 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential-phospholipase C-interacting kinase",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential-related protein, ChaK",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trpm7",
                    "type": "recommended"
                },
                {
                    "name": "2310022G15Rik",
                    "type": "synonym"
                },
                {
                    "name": "4833414K03Rik",
                    "type": "synonym"
                },
                {
                    "name": "5033407O22Rik",
                    "type": "synonym"
                },
                {
                    "name": "CHAK1",
                    "type": "synonym"
                },
                {
                    "name": "CHAK",
                    "type": "synonym"
                },
                {
                    "name": "Chak",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "Ltpr7",
                    "type": "synonym"
                },
                {
                    "name": "Ltrpc7",
                    "type": "synonym"
                },
                {
                    "name": "TRPPLIK",
                    "type": "synonym"
                },
                {
                    "name": "Trpm7",
                    "type": "synonym"
                }
            ],
            "record_id": "Q923J1-1",
            "evidence": [
                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q925B3-1",
            "uniprot_ac": "Q925B3",
            "uniprot_id": "TRPM7_RAT",
            "refseq_ac": "NP_446157",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transient receptor potential cation channel subfamily M member 7",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC7",
                    "type": "synonym"
                },
                {
                    "name": "Long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "TRP-PLIK",
                    "type": "synonym"
                },
                {
                    "name": "Transient receptor potential-phospholipase C-interacting kinase",
                    "type": "synonym"
                },
                {
                    "name": "long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential cation channel subfamily M member 7",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential-phospholipase C-interacting kinase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trpm7",
                    "type": "recommended"
                },
                {
                    "name": "Chak",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "Ltrpc7",
                    "type": "synonym"
                },
                {
                    "name": "Trp-plik",
                    "type": "synonym"
                },
                {
                    "name": "Trpm7",
                    "type": "synonym"
                }
            ],
            "record_id": "Q925B3-1",
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1M5N3-1",
            "uniprot_ac": "F1M5N3",
            "uniprot_id": "F1M5N3_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
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                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                {
                    "name": "Ankyrin 2",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Ank2",
                    "type": "recommended"
                }
            ],
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A8DYE2-1",
            "uniprot_ac": "A8DYE2",
            "uniprot_id": "TRPCG_DROME",
            "refseq_ac": "NP_001036548",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Transient receptor potential cation channel trpm",
                    "type": "recommended"
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                {
                    "name": "CG44240-PB",
                    "type": "synonym"
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                {
                    "name": "Transient receptor potential cation channel, subfamily M ortholog",
                    "type": "synonym"
                },
                {
                    "name": "Trpm-PB",
                    "type": "synonym"
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                {
                    "name": "transient receptor potential cation channel, subfamily M ortholog",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential cation channel, subfamily M, isoform B",
                    "type": "synonym"
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                {
                    "name": "transient receptor potential channel M",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Trpm",
                    "type": "recommended"
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                {
                    "name": "BcDNA:GH04950",
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                },
                {
                    "name": "CG16805",
                    "type": "synonym"
                },
                {
                    "name": "CG30078",
                    "type": "synonym"
                },
                {
                    "name": "CG30079",
                    "type": "synonym"
                },
                {
                    "name": "CG34123",
                    "type": "synonym"
                },
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                    "name": "CG34187",
                    "type": "synonym"
                },
                {
                    "name": "CG44240",
                    "type": "synonym"
                },
                {
                    "name": "DmTRPM",
                    "type": "synonym"
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                {
                    "name": "Dmel\\CG44240",
                    "type": "synonym"
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                {
                    "name": "Dmel_CG44240",
                    "type": "synonym"
                },
                {
                    "name": "TRPM",
                    "type": "synonym"
                },
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                    "name": "TrpM",
                    "type": "synonym"
                },
                {
                    "name": "Trpm",
                    "type": "synonym"
                },
                {
                    "name": "dTRPM",
                    "type": "synonym"
                },
                {
                    "name": "mdcds_11815",
                    "type": "synonym"
                },
                {
                    "name": "trpm",
                    "type": "synonym"
                }
            ],
            "record_id": "A8DYE2-1",
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "M9MRX4-1",
            "uniprot_ac": "M9MRX4",
            "uniprot_id": "M9MRX4_DROME",
            "refseq_ac": "NP_001189070",
            "glycoprotein": "yes",
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                {
                    "name": "Drosophila melanogaster",
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                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "Ank2-PU",
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                },
                {
                    "name": "Ankyrin 2, isoform U",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin2 extra large",
                    "type": "synonym"
                },
                {
                    "name": "CG42734-PU",
                    "type": "synonym"
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                {
                    "name": "Dank2",
                    "type": "synonym"
                },
                {
                    "name": "SP2523",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin 2, isoform U",
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                },
                {
                    "name": "ankyrin2-XL",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Ank2",
                    "type": "recommended"
                },
                {
                    "name": "Ank2",
                    "type": "synonym"
                },
                {
                    "name": "CG18025",
                    "type": "synonym"
                },
                {
                    "name": "CG18227",
                    "type": "synonym"
                },
                {
                    "name": "CG18768",
                    "type": "synonym"
                },
                {
                    "name": "CG32373",
                    "type": "synonym"
                },
                {
                    "name": "CG32375",
                    "type": "synonym"
                },
                {
                    "name": "CG32377",
                    "type": "synonym"
                },
                {
                    "name": "CG34121",
                    "type": "synonym"
                },
                {
                    "name": "CG34158",
                    "type": "synonym"
                },
                {
                    "name": "CG34416",
                    "type": "synonym"
                },
                {
                    "name": "CG42734",
                    "type": "synonym"
                },
                {
                    "name": "CG7462",
                    "type": "synonym"
                },
                {
                    "name": "CG7493",
                    "type": "synonym"
                },
                {
                    "name": "DAnk2",
                    "type": "synonym"
                },
                {
                    "name": "Dank2",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG42734",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG42734",
                    "type": "synonym"
                },
                {
                    "name": "ESTS:149B10S",
                    "type": "synonym"
                },
                {
                    "name": "SP2523",
                    "type": "synonym"
                },
                {
                    "name": "ank2-L",
                    "type": "synonym"
                },
                {
                    "name": "ank2",
                    "type": "synonym"
                },
                {
                    "name": "dank2",
                    "type": "synonym"
                },
                {
                    "name": "sp2523",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q0KIE7-1",
            "uniprot_ac": "Q0KIE7",
            "uniprot_id": "Q0KIE7_DROME",
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                {
                    "name": "Drosophila melanogaster",
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                    "common_name": "Fruit fly",
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                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                    "name": "Ank-PE",
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                {
                    "name": "Ank1",
                    "type": "synonym"
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                {
                    "name": "Ankyrin, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin, isoform D",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin, isoform E",
                    "type": "synonym"
                },
                {
                    "name": "CG1651-PE",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin, isoform E",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ank",
                    "type": "recommended"
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                {
                    "name": "ANK",
                    "type": "synonym"
                },
                {
                    "name": "Ank",
                    "type": "synonym"
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                {
                    "name": "CG1651",
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                {
                    "name": "CG32008",
                    "type": "synonym"
                },
                {
                    "name": "DAnk1",
                    "type": "synonym"
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                {
                    "name": "Dank1",
                    "type": "synonym"
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                {
                    "name": "Dmel\\CG1651",
                    "type": "synonym"
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                {
                    "name": "Dmel_CG1651",
                    "type": "synonym"
                },
                {
                    "name": "ank",
                    "type": "synonym"
                },
                {
                    "name": "dank1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q96QT4-1",
            "uniprot_ac": "Q96QT4",
            "uniprot_id": "TRPM7_HUMAN",
            "refseq_ac": "NP_001288141",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transient receptor potential cation channel subfamily M member 7",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "Channel-kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "LTRPC ion channel family member 7",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC7",
                    "type": "synonym"
                },
                {
                    "name": "Long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "channel-kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "long transient receptor potential channel 7",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential cation channel subfamily M member 7 isoform b",
                    "type": "synonym"
                },
                {
                    "name": "transient receptor potential-phospholipase C-interacting kinase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TRPM7",
                    "type": "recommended"
                },
                {
                    "name": "ALSPDC",
                    "type": "synonym"
                },
                {
                    "name": "CHAK1",
                    "type": "synonym"
                },
                {
                    "name": "CHAK",
                    "type": "synonym"
                },
                {
                    "name": "LTRPC7",
                    "type": "synonym"
                },
                {
                    "name": "LTrpC-7",
                    "type": "synonym"
                },
                {
                    "name": "TRP-PLIK",
                    "type": "synonym"
                },
                {
                    "name": "TRPM7",
                    "type": "synonym"
                }
            ],
            "record_id": "Q96QT4-1",
            "evidence": [
                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q01484-4",
            "uniprot_ac": "Q01484",
            "uniprot_id": "ANK2_HUMAN",
            "refseq_ac": "NP_001120965",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ankyrin-2",
                    "type": "recommended"
                },
                {
                    "name": "ANK-2",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin-B",
                    "type": "synonym"
                },
                {
                    "name": "Brain ankyrin",
                    "type": "synonym"
                },
                {
                    "name": "Non-erythroid ankyrin",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin 2, neuronal",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin B",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin, brain",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-2 isoform 3",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-2, nonerythrocytic",
                    "type": "synonym"
                },
                {
                    "name": "non-erythroid ankyrin",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ANK2",
                    "type": "recommended"
                },
                {
                    "name": "ANK-2",
                    "type": "synonym"
                },
                {
                    "name": "ANK2",
                    "type": "synonym"
                },
                {
                    "name": "ANKB",
                    "type": "synonym"
                },
                {
                    "name": "CFAP87",
                    "type": "synonym"
                },
                {
                    "name": "FAP87",
                    "type": "synonym"
                },
                {
                    "name": "LQT4",
                    "type": "synonym"
                },
                {
                    "name": "brank-2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q01484-4",
            "evidence": [
                {
                    "id": "0050824",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050824"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050824"
}