{
    "disease_id": "DOID:0050748",
    "recommended_name": {
        "id": "DOID:0050748",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050748",
        "name": "marginal zone lymphoma",
        "description": "A B-cell lymphoma arising from the marginal zone of lymphoid tissues that is characterized by the presence of small to medium sized atypical lymphocytes."
    },
    "synonyms": [
        {
            "id": "DOID:0050748",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050748",
            "name": "marginal zone B-cell lymphoma",
            "description": ""
        }
    ],
    "children": [
        {
            "id": "DOID:0050750",
            "label": "splenic marginal zone lymphoma",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0050909",
            "label": "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0050909",
        "DOID:0050748",
        "DOID:0050750"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050748",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050748",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q8WM94-1",
            "uniprot_ac": "Q8WM94",
            "uniprot_id": "Q8WM94_DANRE",
            "refseq_ac": "NP_001007206",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "MHC class II",
                    "type": "synonym"
                },
                {
                    "name": "Uncharacterized protein LOC368614 precursor",
                    "type": "synonym"
                },
                {
                    "name": "alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC368614 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2dga",
                    "type": "recommended"
                },
                {
                    "name": "MHCII",
                    "type": "synonym"
                },
                {
                    "name": "mhc2d8.35a2",
                    "type": "synonym"
                },
                {
                    "name": "mhc2dga",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-194e12.11",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-48c11.3",
                    "type": "synonym"
                },
                {
                    "name": "si:dz194e12.11",
                    "type": "synonym"
                },
                {
                    "name": "si:dz48c11.3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8WM94-1",
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                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0AB32TP70-1",
            "uniprot_ac": "A0AB32TP70",
            "uniprot_id": "A0AB32TP70_DANRE",
            "refseq_ac": "",
            "glycoprotein": "no",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Uncharacterized protein isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "hla-dpa1",
                    "type": "recommended"
                },
                {
                    "name": "zgc:123107",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TP70-1",
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                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M2B5P7-1",
            "uniprot_ac": "A0A8M2B5P7",
            "uniprot_id": "A0A8M2B5P7_DANRE",
            "refseq_ac": "XP_005159251",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2dbb",
                    "type": "recommended"
                },
                {
                    "name": "DBB",
                    "type": "synonym"
                },
                {
                    "name": "mhc2d18b",
                    "type": "synonym"
                },
                {
                    "name": "mhc2dbb",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "si:dz241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153067",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2B5P7-1",
            "evidence": [
                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M1NAM7-1",
            "uniprot_ac": "A0A8M1NAM7",
            "uniprot_id": "A0A8M1NAM7_DANRE",
            "refseq_ac": "NP_001071221",
            "glycoprotein": "no",
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                {
                    "name": "Danio rerio",
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                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "MHC class II",
                    "type": "synonym"
                },
                {
                    "name": "Uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2d8.45b1",
                    "type": "recommended"
                },
                {
                    "name": "mhc2d8.45b1",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-228j01.6",
                    "type": "synonym"
                },
                {
                    "name": "si:dz228j01.6",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1NAM7-1",
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                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01910-1",
            "uniprot_ac": "P01910",
            "uniprot_id": "HA2K_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "H-2 class II histocompatibility antigen, A-K alpha chain",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "H2-Aa",
                    "type": "recommended"
                }
            ],
            "record_id": "P01910-1",
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                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01921-1",
            "uniprot_ac": "P01921",
            "uniprot_id": "HB2D_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "H-2 class II histocompatibility antigen, A-D beta chain",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "H2-Ab1",
                    "type": "recommended"
                },
                {
                    "name": "H2-iabeta",
                    "type": "synonym"
                }
            ],
            "record_id": "P01921-1",
            "evidence": [
                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P20037-1",
            "uniprot_ac": "P20037",
            "uniprot_id": "HA2B_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rano class II histocompatibility antigen, B alpha chain",
                    "type": "recommended"
                },
                {
                    "name": "RT1 class II antigen, Ba chain",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RT1-Ba",
                    "type": "recommended"
                }
            ],
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                {
                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06341-1",
            "uniprot_ac": "P06341",
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                }
            ],
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        {
            "uniprot_canonical_ac": "P29826-1",
            "uniprot_ac": "P29826",
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                    "name": "Rattus norvegicus",
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                }
            ],
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                {
                    "name": "Rano class II histocompatibility antigen, B-1 beta chain",
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                {
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                    "type": "recommended"
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                    "id": "0050748",
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            "uniprot_canonical_ac": "P03372-1",
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                {
                    "name": "Homo sapiens",
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Estrogen receptor",
                    "type": "recommended"
                },
                {
                    "name": "E2 receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "ER-alpha",
                    "type": "synonym"
                },
                {
                    "name": "ER",
                    "type": "synonym"
                },
                {
                    "name": "Estradiol receptor",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 3 group A member 1",
                    "type": "synonym"
                },
                {
                    "name": "estradiol receptor",
                    "type": "synonym"
                },
                {
                    "name": "estrogen nuclear receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor alpha E1-E2-1-2",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor alpha E1-N2-E2-1-2",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 3 group A member 1",
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                },
                {
                    "name": "oestrogen receptor alpha",
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                }
            ],
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                {
                    "name": "ESR1",
                    "type": "recommended"
                },
                {
                    "name": "ER",
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                },
                {
                    "name": "ESR1",
                    "type": "synonym"
                },
                {
                    "name": "ESRA",
                    "type": "synonym"
                },
                {
                    "name": "ESR",
                    "type": "synonym"
                },
                {
                    "name": "ESTRR",
                    "type": "synonym"
                },
                {
                    "name": "Era",
                    "type": "synonym"
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                {
                    "name": "NR3A1",
                    "type": "synonym"
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            ],
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                {
                    "id": "0050748",
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            "uniprot_canonical_ac": "P01920-1",
            "uniprot_ac": "P01920",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
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                },
                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor",
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                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
                    "type": "synonym"
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                {
                    "name": "MHC class II DQ beta chain",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II HLA-DQ beta glycoprotein",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen DQB1",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen HLA-DQ-beta-1",
                    "type": "synonym"
                }
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                    "name": "HLA-DQB1",
                    "type": "recommended"
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                    "name": "CELIAC1",
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                {
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                    "name": "HLA-DQB",
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                {
                    "name": "IDDM1",
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                    "id": "0050748",
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                }
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            "uniprot_canonical_ac": "P01909-1",
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                    "taxid": 9606,
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                    "name": "HLA class II histocompatibility antigen, DQ alpha 1 chain",
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                    "name": "DC-1 alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "DC-alpha",
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                {
                    "name": "HLA class II histocompatibility antigen DQ alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "HLA class II histocompatibility antigen, DQ alpha 1 chain precursor",
                    "type": "synonym"
                },
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                    "name": "HLA class II histocompatibility antigen, DQ alpha 1 chain",
                    "type": "synonym"
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                    "name": "HLA-DCA",
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                {
                    "name": "MHC HLA-DQ alpha",
                    "type": "synonym"
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                {
                    "name": "MHC class II DQ alpha chain",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II DQA1",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II HLA-DQ-alpha-1",
                    "type": "synonym"
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                {
                    "name": "MHC class II antigen DQA1",
                    "type": "synonym"
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                {
                    "name": "MHC class II protein",
                    "type": "synonym"
                }
            ],
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                    "name": "HLA-DQA1",
                    "type": "recommended"
                },
                {
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                },
                {
                    "name": "DQ-A1",
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                {
                    "name": "DQA1",
                    "type": "synonym"
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                {
                    "name": "HLA-DQA1*",
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                {
                    "name": "HLA-DQA1",
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                {
                    "name": "HLA-DQA",
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                    "id": "0050748",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050748"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050748"
}