{
    "disease_id": "DOID:0050668",
    "recommended_name": {
        "id": "DOID:0050668",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050668",
        "name": "alcohol-related birth defects",
        "description": "A fetal alcohol spectrum disorder that results in damage to organs, bones, or muscles due to prenatal alcohol exposure."
    },
    "synonyms": [
        {
            "id": "DOID:0050668",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050668",
            "name": "ARBD",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050668"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050668",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050668",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AC58GX00-1",
            "uniprot_ac": "A0AC58GX00",
            "uniprot_id": "A0AC58GX00_DANRE",
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            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Ankyrin-3 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-3 isoform X1",
                    "type": "synonym"
                }
            ],
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                {
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                },
                {
                    "name": "ank3b",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050668",
                    "database": "AGR",
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                }
            ]
        },
        {
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            "refseq_ac": "XP_009291354",
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                {
                    "name": "Danio rerio",
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                }
            ],
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                {
                    "name": "Rho guanine nucleotide exchange factor 10",
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                    "name": "rho guanine nucleotide exchange factor 10 isoform X1",
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                }
            ]
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                }
            ],
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                    "name": "2.7.11.1",
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                    "name": "ribosomal protein S6 kinase alpha-1 isoform X1",
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                }
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                {
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                    "name": "rps6ka1",
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                },
                {
                    "name": "wu:fc56h07",
                    "type": "synonym"
                },
                {
                    "name": "zgc:152654",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050668",
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                }
            ]
        },
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                    "name": "Mus musculus",
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                }
            ],
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                    "name": "Ankyrin-3",
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                    "name": "Ankyrin-G",
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                {
                    "name": "ankyrin-3 isoform g",
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                {
                    "name": "brain-specific ankyrin-G",
                    "type": "synonym"
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                    "name": "2900054D09Rik",
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                {
                    "name": "Ank3",
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                {
                    "name": "AnkG",
                    "type": "synonym"
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                    "name": "Ankyrin-G",
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                {
                    "id": "0050668",
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                }
            ]
        },
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                {
                    "name": "Mus musculus",
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                }
            ],
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                {
                    "name": "Rho guanine nucleotide exchange factor 10",
                    "type": "recommended"
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                {
                    "name": "Rho guanine nucleotide exchange factor (GEF) 10",
                    "type": "synonym"
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                {
                    "name": "rho guanine nucleotide exchange factor 10 isoform b",
                    "type": "synonym"
                }
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                {
                    "name": "Arhgef10",
                    "type": "recommended"
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                {
                    "name": "6430549H08Rik",
                    "type": "synonym"
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                {
                    "name": "Arhgef10",
                    "type": "synonym"
                },
                {
                    "name": "Kiaa0294",
                    "type": "synonym"
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                {
                    "name": "mKIAA0294",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P18653-1",
            "uniprot_ac": "P18653",
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                {
                    "name": "Mus musculus",
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                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Ribosomal protein S6 kinase alpha-1",
                    "type": "recommended"
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                    "name": "2.7.11.1",
                    "type": "synonym"
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                    "type": "synonym"
                },
                {
                    "name": "MAP kinase-activated protein kinase 1a",
                    "type": "synonym"
                },
                {
                    "name": "MAPK-activated protein kinase 1a",
                    "type": "synonym"
                },
                {
                    "name": "MAPKAP kinase 1a",
                    "type": "synonym"
                },
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                    "name": "MAPKAPK-1a",
                    "type": "synonym"
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                {
                    "name": "Ribosomal S6 kinase 1",
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                {
                    "name": "Ribosomal protein S6 kinase, 90kD, 1",
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                },
                {
                    "name": "S6K-alpha-1",
                    "type": "synonym"
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                    "name": "p90-RSK 1",
                    "type": "synonym"
                },
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                    "name": "p90RSK1",
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                    "name": "ribosomal protein S6 kinase alpha-1 isoform b",
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                    "name": "ribosomal protein S6 kinase alpha-1",
                    "type": "synonym"
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                    "name": "ribosomal protein S6 kinase polypeptide 1",
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                    "name": "ribosomal protein S6 kinase, 90kD, polypeptide 1",
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                }
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                    "name": "Rps6ka1",
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                    "name": "Mapkapk-1a",
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                    "name": "Mapkapk1a",
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                {
                    "name": "Rps6ka1",
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                    "name": "Rsk-1",
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                    "name": "Rsk1",
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                    "name": "p90Rsk1",
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                    "name": "p90rsk",
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                    "id": "0050668",
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                }
            ]
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            "uniprot_canonical_ac": "P38070-1",
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                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
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                }
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                    "name": "putative protein kinase YPK3",
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                    "id": "0050668",
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                    "name": "ankyrin 3, epithelial",
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                    "name": "ankyrin 3, node of Ranvier (ankyrin G)",
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                    "id": "0050668",
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                    "name": "Rho guanine nucleotide exchange factor 10",
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                    "name": "Rho guanine nucleotide exchange factor (GEF) 10",
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                    "name": "RGD1565043",
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                    "id": "0050668",
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                {
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                    "id": "0050668",
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                    "name": "dank1",
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                    "id": "0050668",
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            ]
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                }
            ],
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                    "name": "DH domain-containing protein",
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                    "name": "CG43658-PC",
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                {
                    "name": "uncharacterized protein, isoform C",
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                }
            ],
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                {
                    "name": "CG12432",
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                {
                    "name": "CG8557",
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                },
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                    "name": "CG12432",
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                },
                {
                    "name": "CG43658",
                    "type": "synonym"
                },
                {
                    "name": "CG8557",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG43658",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG43658",
                    "type": "synonym"
                }
            ],
            "record_id": "M9PHU0-1",
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                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VR61-1",
            "uniprot_ac": "Q9VR61",
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            "refseq_ac": "NP_001259779",
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                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                {
                    "name": "non-specific serine/threonine protein kinase",
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                },
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                    "name": "2.7.11.1",
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                },
                {
                    "name": "CG17596-PB",
                    "type": "synonym"
                },
                {
                    "name": "RPS6-protein kinase-II",
                    "type": "synonym"
                },
                {
                    "name": "Ribosomal-S6-kinase",
                    "type": "synonym"
                },
                {
                    "name": "S6 kinase II",
                    "type": "synonym"
                },
                {
                    "name": "S6kII-PB",
                    "type": "synonym"
                },
                {
                    "name": "ignorant",
                    "type": "synonym"
                },
                {
                    "name": "p90 ribosomal S6 kinase",
                    "type": "synonym"
                },
                {
                    "name": "ribosomal protein S6 kinase II, isoform B",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "S6kII",
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                },
                {
                    "name": "CG17596",
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                },
                {
                    "name": "D-RSK",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG17596",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG17596",
                    "type": "synonym"
                },
                {
                    "name": "RSK",
                    "type": "synonym"
                },
                {
                    "name": "Rsk",
                    "type": "synonym"
                },
                {
                    "name": "S6KII",
                    "type": "synonym"
                },
                {
                    "name": "S6kII",
                    "type": "synonym"
                },
                {
                    "name": "dRSK",
                    "type": "synonym"
                },
                {
                    "name": "dRsk",
                    "type": "synonym"
                },
                {
                    "name": "ign",
                    "type": "synonym"
                },
                {
                    "name": "rsk2",
                    "type": "synonym"
                },
                {
                    "name": "rsk",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VR61-1",
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                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q15418-1",
            "uniprot_ac": "Q15418",
            "uniprot_id": "KS6A1_HUMAN",
            "refseq_ac": "NP_001006666",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ribosomal protein S6 kinase alpha-1",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "90 kDa ribosomal protein S6 kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "MAP kinase-activated protein kinase 1a",
                    "type": "synonym"
                },
                {
                    "name": "MAPK-activated protein kinase 1a",
                    "type": "synonym"
                },
                {
                    "name": "MAPKAP kinase 1a",
                    "type": "synonym"
                },
                {
                    "name": "MAPKAPK-1a",
                    "type": "synonym"
                },
                {
                    "name": "RSK-1",
                    "type": "synonym"
                },
                {
                    "name": "Ribosomal S6 kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "S6K-alpha 1",
                    "type": "synonym"
                },
                {
                    "name": "S6K-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)",
                    "type": "synonym"
                },
                {
                    "name": "p90-RSK 1",
                    "type": "synonym"
                },
                {
                    "name": "p90RSK1",
                    "type": "synonym"
                },
                {
                    "name": "p90S6K",
                    "type": "synonym"
                },
                {
                    "name": "ribosomal S6 kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "ribosomal protein S6 kinase alpha-1 isoform b",
                    "type": "synonym"
                },
                {
                    "name": "ribosomal protein S6 kinase alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "ribosomal protein S6 kinase, 90kDa, polypeptide 1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "RPS6KA1",
                    "type": "recommended"
                },
                {
                    "name": "HU-1",
                    "type": "synonym"
                },
                {
                    "name": "MAPKAPK1A",
                    "type": "synonym"
                },
                {
                    "name": "MAPKAPK1",
                    "type": "synonym"
                },
                {
                    "name": "RPS6KA1",
                    "type": "synonym"
                },
                {
                    "name": "RSK1",
                    "type": "synonym"
                },
                {
                    "name": "RSK",
                    "type": "synonym"
                },
                {
                    "name": "p90Rsk",
                    "type": "synonym"
                }
            ],
            "record_id": "Q15418-1",
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                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O15013-1",
            "uniprot_ac": "O15013",
            "uniprot_id": "ARHGA_HUMAN",
            "refseq_ac": "NP_001295081",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rho guanine nucleotide exchange factor 10",
                    "type": "recommended"
                },
                {
                    "name": "Rho guanine nucleotide exchange factor (GEF) 10",
                    "type": "synonym"
                },
                {
                    "name": "rho guanine nucleotide exchange factor 10 isoform 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ARHGEF10",
                    "type": "recommended"
                },
                {
                    "name": "ARHGEF10",
                    "type": "synonym"
                },
                {
                    "name": "GEF10",
                    "type": "synonym"
                },
                {
                    "name": "KIAA0294",
                    "type": "synonym"
                },
                {
                    "name": "SNCV",
                    "type": "synonym"
                }
            ],
            "record_id": "O15013-1",
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                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q12955-3",
            "uniprot_ac": "Q12955",
            "uniprot_id": "ANK3_HUMAN",
            "refseq_ac": "NP_001140",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ankyrin-3",
                    "type": "recommended"
                },
                {
                    "name": "ANK-3",
                    "type": "synonym"
                },
                {
                    "name": "Ankyrin-G",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin 3, node of Ranvier (ankyrin G)",
                    "type": "synonym"
                },
                {
                    "name": "ankyrin-3 isoform 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ANK3",
                    "type": "recommended"
                },
                {
                    "name": "ANK3",
                    "type": "synonym"
                },
                {
                    "name": "ANKYRIN-G",
                    "type": "synonym"
                },
                {
                    "name": "MRT37",
                    "type": "synonym"
                }
            ],
            "record_id": "Q12955-3",
            "evidence": [
                {
                    "id": "0050668",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050668"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050668"
}