{
    "disease_id": "DOID:0050665",
    "recommended_name": {
        "id": "DOID:0050665",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050665",
        "name": "fetal alcohol syndrome",
        "description": "A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0050665"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050665",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050665",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q6NUX8-1",
            "uniprot_ac": "Q6NUX8",
            "uniprot_id": "RHOAA_DANRE",
            "refseq_ac": "NP_998302",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rho-related GTP-binding protein RhoA-A",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "rho-related GTP-binding protein RhoA-A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "rhoaa",
                    "type": "recommended"
                },
                {
                    "name": "Rhoa",
                    "type": "synonym"
                },
                {
                    "name": "rhoaa",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa66g04",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb26g07",
                    "type": "synonym"
                },
                {
                    "name": "zgc:66058",
                    "type": "synonym"
                },
                {
                    "name": "zgc:85805",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6NUX8-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6DHE8-1",
            "uniprot_ac": "Q6DHE8",
            "uniprot_id": "RHOAD_DANRE",
            "refseq_ac": "NP_001002445",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rho-related GTP-binding protein RhoA-D",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "ras homolog gene family, member Ad",
                    "type": "synonym"
                },
                {
                    "name": "rho-related GTP-binding protein RhoA-D",
                    "type": "synonym"
                },
                {
                    "name": "rho-related GTP-binding protein RhoC",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "rhoad",
                    "type": "recommended"
                },
                {
                    "name": "rhoad",
                    "type": "synonym"
                },
                {
                    "name": "rhocb",
                    "type": "synonym"
                },
                {
                    "name": "zgc:92350",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6DHE8-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q7T2E8-1",
            "uniprot_ac": "Q7T2E8",
            "uniprot_id": "RHOAC_DANRE",
            "refseq_ac": "NP_998515",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rho-related GTP-binding protein RhoA-C",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "rho-related GTP-binding protein RhoA-C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "rhoac",
                    "type": "recommended"
                },
                {
                    "name": "rhoac",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc17g01",
                    "type": "synonym"
                },
                {
                    "name": "zgc:63939",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7T2E8-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6DHM9-1",
            "uniprot_ac": "Q6DHM9",
            "uniprot_id": "RHOAB_DANRE",
            "refseq_ac": "NP_997914",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rho-related GTP-binding protein RhoA-B",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "rho-related GTP-binding protein RhoA-B",
                    "type": "synonym"
                },
                {
                    "name": "small GTPase RhoA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "rhoab",
                    "type": "recommended"
                },
                {
                    "name": "arha",
                    "type": "synonym"
                },
                {
                    "name": "rhoab",
                    "type": "synonym"
                },
                {
                    "name": "rhoa",
                    "type": "synonym"
                },
                {
                    "name": "wu:fj42e08",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153713",
                    "type": "synonym"
                },
                {
                    "name": "zgc:92206",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6DHM9-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9QUI0-1",
            "uniprot_ac": "Q9QUI0",
            "uniprot_id": "RHOA_MOUSE",
            "refseq_ac": "NP_001300890",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transforming protein RhoA",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "aplysia ras-related homolog A",
                    "type": "synonym"
                },
                {
                    "name": "ras homolog gene family, member A",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein RhoA precursor",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein RhoA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rhoa",
                    "type": "recommended"
                },
                {
                    "name": "Arha1",
                    "type": "synonym"
                },
                {
                    "name": "Arha2",
                    "type": "synonym"
                },
                {
                    "name": "Arha",
                    "type": "synonym"
                },
                {
                    "name": "Rhoa",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9QUI0-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06780-1",
            "uniprot_ac": "P06780",
            "uniprot_id": "RHO1_YEAST",
            "refseq_ac": "NP_015491",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "GTP-binding protein RHO1",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "Rho family GTPase RHO1",
                    "type": "synonym"
                },
                {
                    "name": "Rho-type GTPase 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RHO1",
                    "type": "recommended"
                },
                {
                    "name": "P9325.3",
                    "type": "synonym"
                },
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                    "name": "RHO1",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P61589-1",
            "uniprot_ac": "P61589",
            "uniprot_id": "RHOA_RAT",
            "refseq_ac": "NP_476473",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transforming protein RhoA",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "plysia ras-related homolog A2",
                    "type": "synonym"
                },
                {
                    "name": "ras homolog gene family, member A",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein RhoA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rhoa",
                    "type": "recommended"
                },
                {
                    "name": "Arha2",
                    "type": "synonym"
                },
                {
                    "name": "Arha",
                    "type": "synonym"
                },
                {
                    "name": "Rhoa",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P48148-1",
            "uniprot_ac": "P48148",
            "uniprot_id": "RHO1_DROME",
            "refseq_ac": "NP_477098",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ras-like GTP-binding protein Rho1",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "CG8416-PA",
                    "type": "synonym"
                },
                {
                    "name": "Rho GTPase",
                    "type": "synonym"
                },
                {
                    "name": "Rho1, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Rho1-PA",
                    "type": "synonym"
                },
                {
                    "name": "RhoA kinase",
                    "type": "synonym"
                },
                {
                    "name": "RhoA",
                    "type": "synonym"
                },
                {
                    "name": "rho kinase",
                    "type": "synonym"
                },
                {
                    "name": "rho1 kinase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Rho1",
                    "type": "recommended"
                },
                {
                    "name": "19549712",
                    "type": "synonym"
                },
                {
                    "name": "8416",
                    "type": "synonym"
                },
                {
                    "name": "AAF01186",
                    "type": "synonym"
                },
                {
                    "name": "CG8416",
                    "type": "synonym"
                },
                {
                    "name": "D-Rho1",
                    "type": "synonym"
                },
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                    "name": "DRho1",
                    "type": "synonym"
                },
                {
                    "name": "DRhoA",
                    "type": "synonym"
                },
                {
                    "name": "DRho",
                    "type": "synonym"
                },
                {
                    "name": "Dm Rho1",
                    "type": "synonym"
                },
                {
                    "name": "DmRHO-A",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8416",
                    "type": "synonym"
                },
                {
                    "name": "Drho1",
                    "type": "synonym"
                },
                {
                    "name": "DrhoA",
                    "type": "synonym"
                },
                {
                    "name": "E3.10/J3.8",
                    "type": "synonym"
                },
                {
                    "name": "P48148",
                    "type": "synonym"
                },
                {
                    "name": "RHO1",
                    "type": "synonym"
                },
                {
                    "name": "RHOA",
                    "type": "synonym"
                },
                {
                    "name": "RHO",
                    "type": "synonym"
                },
                {
                    "name": "Rho A",
                    "type": "synonym"
                },
                {
                    "name": "Rho GTPase",
                    "type": "synonym"
                },
                {
                    "name": "Rho1",
                    "type": "synonym"
                },
                {
                    "name": "RhoA",
                    "type": "synonym"
                },
                {
                    "name": "RhoN19",
                    "type": "synonym"
                },
                {
                    "name": "Rho",
                    "type": "synonym"
                },
                {
                    "name": "dRho1",
                    "type": "synonym"
                },
                {
                    "name": "dRhoA",
                    "type": "synonym"
                },
                {
                    "name": "dnRho",
                    "type": "synonym"
                },
                {
                    "name": "l(2)52Fa",
                    "type": "synonym"
                },
                {
                    "name": "l(2)k02107b",
                    "type": "synonym"
                },
                {
                    "name": "n(2)k07236",
                    "type": "synonym"
                },
                {
                    "name": "rho1",
                    "type": "synonym"
                },
                {
                    "name": "rhoA",
                    "type": "synonym"
                },
                {
                    "name": "rho",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P61586-1",
            "uniprot_ac": "P61586",
            "uniprot_id": "RHOA_HUMAN",
            "refseq_ac": "NP_001300870",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Transforming protein RhoA",
                    "type": "recommended"
                },
                {
                    "name": "3.6.5.2",
                    "type": "synonym"
                },
                {
                    "name": "Aplysia ras-related homolog 12",
                    "type": "synonym"
                },
                {
                    "name": "Rho cDNA clone 12",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "h12",
                    "type": "synonym"
                },
                {
                    "name": "oncogene RHO H12",
                    "type": "synonym"
                },
                {
                    "name": "small GTP binding protein RhoA",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein RhoA isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "transforming protein RhoA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RHOA",
                    "type": "recommended"
                },
                {
                    "name": "ARH12",
                    "type": "synonym"
                },
                {
                    "name": "ARHA",
                    "type": "synonym"
                },
                {
                    "name": "EDFAOB",
                    "type": "synonym"
                },
                {
                    "name": "RHO12",
                    "type": "synonym"
                },
                {
                    "name": "RHOA",
                    "type": "synonym"
                },
                {
                    "name": "RHOH12",
                    "type": "synonym"
                }
            ],
            "record_id": "P61586-1",
            "evidence": [
                {
                    "id": "0050665",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050665"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050665"
}