{
    "disease_id": "DOID:0050628",
    "recommended_name": {
        "id": "DOID:0050628",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050628",
        "name": "advanced sleep phase syndrome",
        "description": "A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning."
    },
    "synonyms": [
        {
            "id": "DOID:0050628",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050628",
            "name": "familial advanced sleep-phase syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "advanced sleep phase syndrome 1",
            "description": "Any advanced sleep phase syndrome in which the cause of the disease is a mutation in the PER2 gene."
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "FASPS1",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "PER2 advanced sleep phase syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "advanced sleep phase syndrome caused by mutation in PER2",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "advanced sleep phase syndrome type 1",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "advanced sleep phase syndrome, familial, type 1",
            "description": ""
        },
        {
            "id": "MONDO:0011442",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "name": "advanced sleep phase syndrome, familial, 1",
            "description": ""
        },
        {
            "id": "MIM:604348",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/604348",
            "name": "Advanced sleep phase syndrome, familial, 1",
            "description": "Advanced sleep phase syndrome, familial, 1"
        }
    ],
    "children": [
        {
            "id": "DOID:0061006",
            "label": "advanced sleep phase syndrome 4",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0110011",
            "label": "advanced sleep phase syndrome 1",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0110012",
            "label": "advanced sleep phase syndrome 2",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0110013",
            "label": "advanced sleep phase syndrome 3",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0110011",
        "DOID:0110013",
        "DOID:0110012",
        "DOID:0050628",
        "DOID:0061006"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050628",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050628",
            "categories": []
        },
        {
            "id": "MONDO:0011442",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0011442",
            "categories": []
        },
        {
            "id": "MIM:604348",
            "database": "MIM",
            "url": "https://www.omim.org/entry/604348",
            "categories": []
        }
    ],
    "proteins": [
        {
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            "uniprot_ac": "A0A8M1PBM5",
            "uniprot_id": "A0A8M1PBM5_DANRE",
            "refseq_ac": "NP_571659",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Period circadian protein homolog 3",
                    "type": "synonym"
                },
                {
                    "name": "period circadian protein homolog 3",
                    "type": "synonym"
                },
                {
                    "name": "period homolog 3",
                    "type": "synonym"
                }
            ],
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                    "name": "per3",
                    "type": "recommended"
                },
                {
                    "name": "per3",
                    "type": "synonym"
                },
                {
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                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1PBM5-1",
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                    "id": "0050628",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050628"
                }
            ]
        },
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            "refseq_ac": "XP_021334311",
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                    "name": "Danio rerio",
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                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "Period circadian protein homolog 2",
                    "type": "recommended"
                },
                {
                    "name": "Circadian clock protein PERIOD 2",
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                },
                {
                    "name": "period circadian protein homolog 2 isoform X1",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "per2",
                    "type": "recommended"
                },
                {
                    "name": "fj43b09",
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                {
                    "name": "per2",
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                {
                    "name": "wu:fj43b09",
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            ],
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                    "id": "0050628",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050628"
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            ]
        },
        {
            "uniprot_canonical_ac": "O88816-1",
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                {
                    "name": "Mus musculus",
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                    "common_name": "Mouse",
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                    "reference_species": "Mus musculus [10090]"
                }
            ],
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                {
                    "name": "Serotonin N-acetyltransferase",
                    "type": "recommended"
                },
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                    "name": "2.3.1.87",
                    "type": "synonym"
                },
                {
                    "name": "AA-NAT",
                    "type": "synonym"
                },
                {
                    "name": "Aralkylamine N-acetyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "Serotonin acetylase",
                    "type": "synonym"
                },
                {
                    "name": "aralkylamine N-acetyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "serotonin N-acetyltransferase",
                    "type": "synonym"
                },
                {
                    "name": "serotonin acetylase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Aanat",
                    "type": "recommended"
                },
                {
                    "name": "AA-NAT",
                    "type": "synonym"
                },
                {
                    "name": "Aanat",
                    "type": "synonym"
                },
                {
                    "name": "Nat-2",
                    "type": "synonym"
                },
                {
                    "name": "Nat4",
                    "type": "synonym"
                },
                {
                    "name": "Snat",
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                }
            ],
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                {
                    "id": "0050628",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050628"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O70361-1",
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            "uniprot_id": "PER3_MOUSE",
            "refseq_ac": "NP_035197",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Period circadian protein homolog 3",
                    "type": "recommended"
                },
                {
                    "name": "Circadian clock protein PERIOD 3",
                    "type": "synonym"
                },
                {
                    "name": "circadian clock protein PERIOD 3",
                    "type": "synonym"
                },
                {
                    "name": "mPER3",
                    "type": "synonym"
                },
                {
                    "name": "period circadian protein homolog 3 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "period circadian protein homolog 3",
                    "type": "synonym"
                },
                {
                    "name": "period homolog 3",
                    "type": "synonym"
                }
            ],
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                {
                    "name": "Per3",
                    "type": "recommended"
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                {
                    "name": "2810049O06Rik",
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                },
                {
                    "name": "Per3",
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                    "name": "mPer3",
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                }
            ],
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                    "id": "0050628",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "O54943-1",
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                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Period circadian protein homolog 2",
                    "type": "recommended"
                },
                {
                    "name": "Circadian clock protein PERIOD 2",
                    "type": "synonym"
                },
                {
                    "name": "circadian clock protein PERIOD 2",
                    "type": "synonym"
                },
                {
                    "name": "mPER2",
                    "type": "synonym"
                },
                {
                    "name": "period 2",
                    "type": "synonym"
                },
                {
                    "name": "period circadian protein homolog 2 isoform 1",
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                },
                {
                    "name": "period circadian protein homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "period homolog 2",
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                }
            ],
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                    "name": "Per2",
                    "type": "recommended"
                },
                {
                    "name": "Per2",
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                },
                {
                    "name": "mKIAA0347",
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                {
                    "name": "mPer2",
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                }
            ],
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                    "id": "0050628",
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                }
            ]
        },
        {
            "uniprot_canonical_ac": "O15055-1",
            "uniprot_ac": "O15055",
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            "refseq_ac": "NP_073728",
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            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                {
                    "name": "Period circadian protein homolog 2",
                    "type": "recommended"
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                    "name": "Circadian clock protein PERIOD 2",
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                },
                {
                    "name": "circadian clock protein PERIOD 2",
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                },
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                    "name": "hPER2",
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                    "name": "period 2",
                    "type": "synonym"
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                    "name": "period circadian clock 2",
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                    "name": "period circadian protein homolog 2",
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            ],
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                    "name": "PER2",
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                    "name": "FASPS",
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                    "name": "KIAA0347",
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                    "id": "0050628",
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                    "name": "Casein kinase I homolog HRR25",
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                    "id": "0050628",
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                    "name": "Polyamine N-acetyltransferase 1",
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                    "name": "Arylalkylamine N-acetyltransferase homolog",
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                    "id": "0050628",
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                    "name": "Topoisomerase 1-associated factor 1",
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                    "name": "Serotonin N-acetyltransferase",
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                    "name": "AA-NAT",
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                },
                {
                    "name": "Aralkylamine N-acetyltransferase",
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                {
                    "name": "Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)",
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                    "name": "Seretonin N-acetyltransferase",
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                    "name": "Serotonin acetylase",
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                    "name": "arylakylamine N-acetyltransferase",
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                {
                    "name": "arylalkylamine N-acetyltransferase",
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                    "id": "0050628",
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                    "name": "Period circadian protein homolog 3",
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                    "name": "period circadian protein homolog 3",
                    "type": "synonym"
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                    "name": "period homolog 3",
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                    "id": "0050628",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0050628"
                }
            ]
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                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
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                    "name": "Period circadian protein homolog 2",
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                    "name": "Circadian clock protein PERIOD 2",
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                    "name": "circadian clock protein PERIOD 2",
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                {
                    "name": "period circadian clock 2",
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                    "name": "period circadian protein homolog 2",
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                    "name": "rPER2",
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                    "name": "dper",
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                    "name": "mel_per",
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                    "name": "bruchpilot",
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                    "name": "timeless1",
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                    "name": "Dmel\\CG3234",
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                    "name": "Ritsu",
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                    "name": "rit",
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                    "name": "Period circadian protein homolog 3",
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                    "name": "hPER3",
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                    "name": "GIG13",
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            ],
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                {
                    "name": "Aralkylamine N-acetyltransferase",
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                {
                    "name": "Serotonin acetylase",
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                {
                    "name": "arylalkylamine N-acetyltransferase",
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                {
                    "name": "serotonin N-acetyltransferase isoform 2",
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                {
                    "name": "serotonin acetylase",
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                    "name": "AANAT",
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                    "name": "AANAT",
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                }
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        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050628"
}