{
    "disease_id": "DOID:0050468",
    "recommended_name": {
        "id": "DOID:0050468",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050468",
        "name": "yellow nail syndrome",
        "description": "A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached."
    },
    "synonyms": [
        {
            "id": "MONDO:0007921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007921",
            "name": "yellow nail syndrome",
            "description": "A very rare syndromic disorder characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema."
        },
        {
            "id": "MONDO:0007921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007921",
            "name": "YNS",
            "description": ""
        },
        {
            "id": "MONDO:0007921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007921",
            "name": "lymphedema with yellow nails",
            "description": ""
        },
        {
            "id": "MONDO:0007921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007921",
            "name": "yellow nail syndrome",
            "description": ""
        },
        {
            "id": "MIM:153300",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/153300",
            "name": "Yellow nail syndrome",
            "description": "Yellow nail syndrome"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050468"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050468",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050468",
            "categories": []
        },
        {
            "id": "MONDO:0007921",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0007921",
            "categories": []
        },
        {
            "id": "MIM:153300",
            "database": "MIM",
            "url": "https://www.omim.org/entry/153300",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M3ARK0-1",
            "uniprot_ac": "A0A8M3ARK0",
            "uniprot_id": "A0A8M3ARK0_DANRE",
            "refseq_ac": "XP_009298735",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "cadherin EGF LAG seven-pass G-type receptor 1 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "celsr1a",
                    "type": "recommended"
                },
                {
                    "name": "celsr1a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M3ARK0-1",
            "evidence": [
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1QBS8-1",
            "uniprot_ac": "F1QBS8",
            "uniprot_id": "F1QBS8_DANRE",
            "refseq_ac": "XP_001920772",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "synonym"
                },
                {
                    "name": "cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "celsr1b",
                    "type": "recommended"
                },
                {
                    "name": "celsr1b",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QBS8-1",
            "evidence": [
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35161-1",
            "uniprot_ac": "O35161",
            "uniprot_id": "CELR1_MOUSE",
            "refseq_ac": "NP_034016",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "cadherin EGF LAG seven-pass G-type receptor 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)",
                    "type": "synonym"
                },
                {
                    "name": "seven-pass transmembrane receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Celsr1",
                    "type": "recommended"
                },
                {
                    "name": "Adgrc1",
                    "type": "synonym"
                },
                {
                    "name": "Celsr1",
                    "type": "synonym"
                },
                {
                    "name": "Crsh",
                    "type": "synonym"
                },
                {
                    "name": "Scy",
                    "type": "synonym"
                },
                {
                    "name": "crash",
                    "type": "synonym"
                }
            ],
            "record_id": "O35161-1",
            "evidence": [
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NYQ6-1",
            "uniprot_ac": "Q9NYQ6",
            "uniprot_id": "CELR1_HUMAN",
            "refseq_ac": "NP_055061",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "recommended"
                },
                {
                    "name": "Cadherin family member 9",
                    "type": "synonym"
                },
                {
                    "name": "Flamingo homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "adhesion G protein-coupled receptor C1",
                    "type": "synonym"
                },
                {
                    "name": "cadherin EGF LAG seven-pass G-type receptor 1 isoform 2 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cadherin family member 9",
                    "type": "synonym"
                },
                {
                    "name": "cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)",
                    "type": "synonym"
                },
                {
                    "name": "flamingo homolog 2",
                    "type": "synonym"
                },
                {
                    "name": "hFmi2",
                    "type": "synonym"
                },
                {
                    "name": "protocadherin flamingo 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CELSR1",
                    "type": "recommended"
                },
                {
                    "name": "ADGRC1",
                    "type": "synonym"
                },
                {
                    "name": "CDHF9",
                    "type": "synonym"
                },
                {
                    "name": "CELSR1",
                    "type": "synonym"
                },
                {
                    "name": "FMI2",
                    "type": "synonym"
                },
                {
                    "name": "HFMI2",
                    "type": "synonym"
                },
                {
                    "name": "LMPHM9",
                    "type": "synonym"
                },
                {
                    "name": "ME2",
                    "type": "synonym"
                },
                {
                    "name": "YNS",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9NYQ6-1",
            "evidence": [
                {
                    "id": "153300",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/153300"
                },
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0ABK0LG69-1",
            "uniprot_ac": "A0ABK0LG69",
            "uniprot_id": "A0ABK0LG69_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cadherin EGF LAG seven-pass G-type receptor 1",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "Celsr1",
                    "type": "recommended"
                }
            ],
            "record_id": "A0ABK0LG69-1",
            "evidence": [
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9V5N8-1",
            "uniprot_ac": "Q9V5N8",
            "uniprot_id": "STAN_DROME",
            "refseq_ac": "NP_001188903",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Protocadherin-like wing polarity protein stan",
                    "type": "recommended"
                },
                {
                    "name": "CG11895-PC",
                    "type": "synonym"
                },
                {
                    "name": "Protein flamingo",
                    "type": "synonym"
                },
                {
                    "name": "Protein starry night",
                    "type": "synonym"
                },
                {
                    "name": "flamingo",
                    "type": "synonym"
                },
                {
                    "name": "serpentine cadherin",
                    "type": "synonym"
                },
                {
                    "name": "stan-PC",
                    "type": "synonym"
                },
                {
                    "name": "starry night, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "starry night",
                    "type": "synonym"
                },
                {
                    "name": "suppressor of NA9 2-7",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "stan",
                    "type": "recommended"
                },
                {
                    "name": "2R3",
                    "type": "synonym"
                },
                {
                    "name": "CG11895",
                    "type": "synonym"
                },
                {
                    "name": "CT20776",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG11895",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG11895",
                    "type": "synonym"
                },
                {
                    "name": "FMI",
                    "type": "synonym"
                },
                {
                    "name": "Flamingo",
                    "type": "synonym"
                },
                {
                    "name": "Flam",
                    "type": "synonym"
                },
                {
                    "name": "Fmi",
                    "type": "synonym"
                },
                {
                    "name": "SN2-7",
                    "type": "synonym"
                },
                {
                    "name": "STAN",
                    "type": "synonym"
                },
                {
                    "name": "Stan",
                    "type": "synonym"
                },
                {
                    "name": "fmi/stan",
                    "type": "synonym"
                },
                {
                    "name": "fmi",
                    "type": "synonym"
                },
                {
                    "name": "stan",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9V5N8-1",
            "evidence": [
                {
                    "id": "0050468",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050468"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050468"
}