{
    "disease_id": "DOID:0050428",
    "recommended_name": {
        "id": "DOID:0050428",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050428",
        "name": "nonepidermolytic palmoplantar keratoderma",
        "description": "A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles."
    },
    "synonyms": [
        {
            "id": "DOID:0050428",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "name": "Thost-Unna Syndrome",
            "description": ""
        },
        {
            "id": "DOID:0050428",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "name": "Unna-Thost Syndrome",
            "description": ""
        },
        {
            "id": "DOID:0050428",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "name": "diffuse nonepidermolytic palmomplantar keratoderma",
            "description": ""
        },
        {
            "id": "DOID:0050428",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "name": "tylosis",
            "description": ""
        },
        {
            "id": "DOID:0050428",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "name": "NEPPK",
            "description": ""
        }
    ],
    "children": [
        {
            "id": "DOID:0070550",
            "label": "KRT1-related nonepidermolytic palmoplantar keratoderma",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0070554",
            "label": "palmoplantar keratoderma and woolly hair",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0070555",
            "label": "Nagashima-type palmoplantar keratosis",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0080551",
            "label": "Naxos disease",
            "link_status": true,
            "children": [
                {
                    "id": "DOID:0090128",
                    "label": "Carvajal syndrome",
                    "link_status": true,
                    "children": []
                }
            ]
        },
        {
            "id": "DOID:0111707",
            "label": "Bothnian type palmoplantar keratoderma",
            "link_status": true,
            "children": []
        },
        {
            "id": "DOID:0111708",
            "label": "focal nonepidermolytic palmoplantar keratoderma",
            "link_status": false,
            "children": [
                {
                    "id": "DOID:0111709",
                    "label": "focal nonepidermolytic palmoplantar keratoderma 1",
                    "link_status": true,
                    "children": []
                },
                {
                    "id": "DOID:0111711",
                    "label": "focal nonepidermolytic palmoplantar keratoderma 2",
                    "link_status": true,
                    "children": []
                }
            ]
        },
        {
            "id": "DOID:0111710",
            "label": "focal or diffuse nonepidermolytic palmoplantar keratoderma",
            "link_status": true,
            "children": []
        }
    ],
    "id_list": [
        "DOID:0111707",
        "DOID:0090128",
        "DOID:0111708",
        "DOID:0080551",
        "DOID:0111709",
        "DOID:0070555",
        "DOID:0111710",
        "DOID:0050428",
        "DOID:0111711",
        "DOID:0070550",
        "DOID:0070554"
    ],
    "unlinked_id_list": [
        "DOID:0111708"
    ],
    "crossref": [
        {
            "id": "DOID:0050428",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050428",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "B0UYS0-1",
            "uniprot_ac": "B0UYS0",
            "uniprot_id": "B0UYS0_DANRE",
            "refseq_ac": "NP_998688",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Keratin, type I cytoskeletal 15",
                    "type": "synonym"
                },
                {
                    "name": "cytokeratin",
                    "type": "synonym"
                },
                {
                    "name": "keratin, type I cytoskeletal 15",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "krt15",
                    "type": "recommended"
                },
                {
                    "name": "krt15",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa91c06",
                    "type": "synonym"
                },
                {
                    "name": "wu:fa95d04",
                    "type": "synonym"
                },
                {
                    "name": "zgc:55334",
                    "type": "synonym"
                }
            ],
            "record_id": "B0UYS0-1",
            "evidence": [
                {
                    "id": "0050428",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050428"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M1NXG3-1",
            "uniprot_ac": "A0A8M1NXG3",
            "uniprot_id": "A0A8M1NXG3_DANRE",
            "refseq_ac": "NP_001186881",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Keratin 96",
                    "type": "synonym"
                },
                {
                    "name": "keratin 96",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "krt96",
                    "type": "recommended"
                },
                {
                    "name": "fb17f05",
                    "type": "synonym"
                },
                {
                    "name": "krt96",
                    "type": "synonym"
                },
                {
                    "name": "si:rp71-1n18.1",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb17f05",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1NXG3-1",
            "evidence": [
                {
                    "id": "0050428",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050428"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M1N5Q5-1",
            "uniprot_ac": "A0A8M1N5Q5",
            "uniprot_id": "A0A8M1N5Q5_DANRE",
            "refseq_ac": "NP_001017824",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Keratin 92",
                    "type": "synonym"
                },
                {
                    "name": "cytokeratin-like",
                    "type": "synonym"
                },
                {
                    "name": "keratin 92",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "krt92",
                    "type": "recommended"
                },
                {
                    "name": "krt92",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-113d7.5",
                    "type": "synonym"
                },
                {
                    "name": "zgc:109868",
                    "type": "synonym"
                },
                {
                    "name": "zgc:136388",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1N5Q5-1",
            "evidence": [
                {
                    "id": "0050428",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050428"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Z2K1-1",
            "uniprot_ac": "Q9Z2K1",
            "uniprot_id": "K1C16_MOUSE",
            "refseq_ac": "NP_001300887",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Keratin, type I cytoskeletal 16",
                    "type": "recommended"
                },
                {
                    "name": "CK-16",
                    "type": "synonym"
                },
                {
                    "name": "Cytokeratin-16",
                    "type": "synonym"
                },
                {
                    "name": "K16",
                    "type": "synonym"
                },
                {
                    "name": "Keratin-16",
                    "type": "synonym"
                },
                {
                    "name": "cytokeratin-16",
                    "type": "synonym"
                },
                {
                    "name": "keratin complex 1, acidic, gene 16",
                    "type": "synonym"
                },
                {
                    "name": "keratin intermediate filament 16a",
                    "type": "synonym"
                },
                {
                    "name": "keratin intermediate filament 16b",
                    "type": "synonym"
                },
                {
                    "name": "keratin, type I cytoskeletal 16 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "keratin, type I cytoskeletal 16",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Krt16",
                    "type": "recommended"
                },
                {
                    "name": "CK-16",
                    "type": "synonym"
                },
                {
                    "name": "K16",
                    "type": "synonym"
                },
                {
                    "name": "Krt1-16",
                    "type": "synonym"
                },
                {
                    "name": "Krt16",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Z2K1-1",
            "evidence": [
                {
                    "id": "0050428",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050428"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P08779-1",
            "uniprot_ac": "P08779",
            "uniprot_id": "K1C16_HUMAN",
            "refseq_ac": "NP_005548",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Keratin, type I cytoskeletal 16",
                    "type": "recommended"
                },
                {
                    "name": "CK-16",
                    "type": "synonym"
                },
                {
                    "name": "Cytokeratin-16",
                    "type": "synonym"
                },
                {
                    "name": "K16",
                    "type": "synonym"
                },
                {
                    "name": "Keratin-16",
                    "type": "synonym"
                },
                {
                    "name": "cytokeratin 16",
                    "type": "synonym"
                },
                {
                    "name": "focal non-epidermolytic palmoplantar keratoderma",
                    "type": "synonym"
                },
                {
                    "name": "keratin 16, type I",
                    "type": "synonym"
                },
                {
                    "name": "keratin, type I cytoskeletal 16",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "KRT16",
                    "type": "recommended"
                },
                {
                    "name": "CK16",
                    "type": "synonym"
                },
                {
                    "name": "FNEPPK",
                    "type": "synonym"
                },
                {
                    "name": "K16",
                    "type": "synonym"
                },
                {
                    "name": "K1CP",
                    "type": "synonym"
                },
                {
                    "name": "KRT16A",
                    "type": "synonym"
                },
                {
                    "name": "KRT16",
                    "type": "synonym"
                },
                {
                    "name": "NEPPK",
                    "type": "synonym"
                },
                {
                    "name": "PC1",
                    "type": "synonym"
                }
            ],
            "record_id": "P08779-1",
            "evidence": [
                {
                    "id": "0050428",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050428"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050428"
}