{
    "disease_id": "DOID:0050012",
    "recommended_name": {
        "id": "DOID:0050012",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0050012",
        "name": "chikungunya",
        "description": "A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus (Alphavirus chikungunya), which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash."
    },
    "synonyms": [
        {
            "id": "DOID:0050012",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050012",
            "name": "Chikungunya fever",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0050012"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0050012",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0050012",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M2B5P7-1",
            "uniprot_ac": "A0A8M2B5P7",
            "uniprot_id": "A0A8M2B5P7_DANRE",
            "refseq_ac": "XP_005159251",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "major histocompatibility complex class II DBB isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2dbb",
                    "type": "recommended"
                },
                {
                    "name": "DBB",
                    "type": "synonym"
                },
                {
                    "name": "mhc2d18b",
                    "type": "synonym"
                },
                {
                    "name": "mhc2dbb",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "si:dz241h12.1",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153067",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2B5P7-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M1NAM7-1",
            "uniprot_ac": "A0A8M1NAM7",
            "uniprot_id": "A0A8M1NAM7_DANRE",
            "refseq_ac": "NP_001071221",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "MHC class II",
                    "type": "synonym"
                },
                {
                    "name": "Uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                },
                {
                    "name": "uncharacterized protein LOC368846 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mhc2d8.45b1",
                    "type": "recommended"
                },
                {
                    "name": "mhc2d8.45b1",
                    "type": "synonym"
                },
                {
                    "name": "si:busm1-228j01.6",
                    "type": "synonym"
                },
                {
                    "name": "si:dz228j01.6",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1NAM7-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A0G2KYH9-1",
            "uniprot_ac": "A0A0G2KYH9",
            "uniprot_id": "A0A0G2KYH9_DANRE",
            "refseq_ac": "XP_001342606",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "growth-regulated alpha protein isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cxcl8a",
                    "type": "recommended"
                },
                {
                    "name": "cxcl8a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A0G2KYH9-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "N0GW19-1",
            "uniprot_ac": "N0GW19",
            "uniprot_id": "N0GW19_DANRE",
            "refseq_ac": "NP_001314914",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "CXCL8bb",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-8b.1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cxcl8_l2_chr17",
                    "type": "synonym"
                },
                {
                    "name": "il8l2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8, like 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8b.1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "cxcl8b.1",
                    "type": "recommended"
                },
                {
                    "name": "cxcl8b.1",
                    "type": "synonym"
                },
                {
                    "name": "il8l1",
                    "type": "synonym"
                }
            ],
            "record_id": "N0GW19-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01921-1",
            "uniprot_ac": "P01921",
            "uniprot_id": "HB2D_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "H-2 class II histocompatibility antigen, A-D beta chain",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "H2-Ab1",
                    "type": "recommended"
                },
                {
                    "name": "H2-iabeta",
                    "type": "synonym"
                }
            ],
            "record_id": "P01921-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P29826-1",
            "uniprot_ac": "P29826",
            "uniprot_id": "HB2B_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rano class II histocompatibility antigen, B-1 beta chain",
                    "type": "recommended"
                },
                {
                    "name": "RT1 class II histocompatibility antigen, B-1 beta chain",
                    "type": "synonym"
                },
                {
                    "name": "RT1.B-beta(1)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RT1-Bb",
                    "type": "recommended"
                }
            ],
            "record_id": "P29826-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06341-1",
            "uniprot_ac": "P06341",
            "uniprot_id": "HB2A_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Rano class II histocompatibility antigen, A beta chain",
                    "type": "recommended"
                },
                {
                    "name": "RT1 class II histocompatibility antigen, A beta chain",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RT1-B",
                    "type": "recommended"
                }
            ],
            "record_id": "P06341-1",
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                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P03372-1",
            "uniprot_ac": "P03372",
            "uniprot_id": "ESR1_HUMAN",
            "refseq_ac": "NP_000116",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Estrogen receptor",
                    "type": "recommended"
                },
                {
                    "name": "E2 receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "ER-alpha",
                    "type": "synonym"
                },
                {
                    "name": "ER",
                    "type": "synonym"
                },
                {
                    "name": "Estradiol receptor",
                    "type": "synonym"
                },
                {
                    "name": "Nuclear receptor subfamily 3 group A member 1",
                    "type": "synonym"
                },
                {
                    "name": "estradiol receptor",
                    "type": "synonym"
                },
                {
                    "name": "estrogen nuclear receptor alpha",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor alpha E1-E2-1-2",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor alpha E1-N2-E2-1-2",
                    "type": "synonym"
                },
                {
                    "name": "estrogen receptor isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "nuclear receptor subfamily 3 group A member 1",
                    "type": "synonym"
                },
                {
                    "name": "oestrogen receptor alpha",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ESR1",
                    "type": "recommended"
                },
                {
                    "name": "ER",
                    "type": "synonym"
                },
                {
                    "name": "ESR1",
                    "type": "synonym"
                },
                {
                    "name": "ESRA",
                    "type": "synonym"
                },
                {
                    "name": "ESR",
                    "type": "synonym"
                },
                {
                    "name": "ESTRR",
                    "type": "synonym"
                },
                {
                    "name": "Era",
                    "type": "synonym"
                },
                {
                    "name": "NR3A1",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P10145-1",
            "uniprot_ac": "P10145",
            "uniprot_id": "IL8_HUMAN",
            "refseq_ac": "NP_000575",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-8",
                    "type": "recommended"
                },
                {
                    "name": "(Ala-IL-8)77",
                    "type": "synonym"
                },
                {
                    "name": "(Ser-IL-8)72",
                    "type": "synonym"
                },
                {
                    "name": "C-X-C motif chemokine 8",
                    "type": "synonym"
                },
                {
                    "name": "Chemokine (C-X-C motif) ligand 8",
                    "type": "synonym"
                },
                {
                    "name": "Emoctakin",
                    "type": "synonym"
                },
                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein III",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein II",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein IV",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein I",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein VI",
                    "type": "synonym"
                },
                {
                    "name": "GCP/IL-8 protein V",
                    "type": "synonym"
                },
                {
                    "name": "Granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "IL-8(1-77)",
                    "type": "synonym"
                },
                {
                    "name": "IL-8",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form III",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form II",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form IV",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form I",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form VI",
                    "type": "synonym"
                },
                {
                    "name": "IL8/NAP1 form V",
                    "type": "synonym"
                },
                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "Lymphocyte-derived neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-b",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF-c",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF",
                    "type": "synonym"
                },
                {
                    "name": "MONAP",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "Monocyte-derived neutrophil-activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "NAF",
                    "type": "synonym"
                },
                {
                    "name": "NAP-1",
                    "type": "synonym"
                },
                {
                    "name": "Neutrophil-activating factor",
                    "type": "synonym"
                },
                {
                    "name": "Neutrophil-activating protein 1",
                    "type": "synonym"
                },
                {
                    "name": "Protein 3-10C",
                    "type": "synonym"
                },
                {
                    "name": "T-cell chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "alveolar macrophage chemotactic factor I",
                    "type": "synonym"
                },
                {
                    "name": "beta endothelial cell-derived neutrophil activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "beta-thromboglobulin-like protein",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-X-C motif) ligand 8",
                    "type": "synonym"
                },
                {
                    "name": "emoctakin",
                    "type": "synonym"
                },
                {
                    "name": "granulocyte chemotactic protein 1",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 8",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-8 isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "lung giant cell carcinoma-derived chemotactic protein",
                    "type": "synonym"
                },
                {
                    "name": "lymphocyte derived neutrophil activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "monocyte-derived neutrophil chemotactic factor",
                    "type": "synonym"
                },
                {
                    "name": "monocyte-derived neutrophil-activating peptide",
                    "type": "synonym"
                },
                {
                    "name": "neutrophil-activating peptide 1",
                    "type": "synonym"
                },
                {
                    "name": "small inducible cytokine subfamily B, member 8",
                    "type": "synonym"
                },
                {
                    "name": "tumor necrosis factor-induced gene 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CXCL8",
                    "type": "recommended"
                },
                {
                    "name": "CXCL8",
                    "type": "synonym"
                },
                {
                    "name": "GCP-1",
                    "type": "synonym"
                },
                {
                    "name": "GCP1",
                    "type": "synonym"
                },
                {
                    "name": "IL8",
                    "type": "synonym"
                },
                {
                    "name": "LECT",
                    "type": "synonym"
                },
                {
                    "name": "LUCT",
                    "type": "synonym"
                },
                {
                    "name": "LYNAP",
                    "type": "synonym"
                },
                {
                    "name": "MDNCF",
                    "type": "synonym"
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                {
                    "name": "MONAP",
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                },
                {
                    "name": "NAF",
                    "type": "synonym"
                },
                {
                    "name": "NAP-1",
                    "type": "synonym"
                },
                {
                    "name": "NAP1",
                    "type": "synonym"
                },
                {
                    "name": "SCYB8",
                    "type": "synonym"
                }
            ],
            "record_id": "P10145-1",
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                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01920-1",
            "uniprot_ac": "P01920",
            "uniprot_id": "DQB1_HUMAN",
            "refseq_ac": "NP_001230891",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
                    "type": "recommended"
                },
                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "HLA class II histocompatibility antigen, DQ beta 1 chain",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II DQ beta chain",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II HLA-DQ beta glycoprotein",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen DQB1",
                    "type": "synonym"
                },
                {
                    "name": "MHC class II antigen HLA-DQ-beta-1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "HLA-DQB1",
                    "type": "recommended"
                },
                {
                    "name": "CELIAC1",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DQB1",
                    "type": "synonym"
                },
                {
                    "name": "HLA-DQB",
                    "type": "synonym"
                },
                {
                    "name": "IDDM1",
                    "type": "synonym"
                }
            ],
            "record_id": "P01920-1",
            "evidence": [
                {
                    "id": "0050012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050012"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0050012"
}