{
    "disease_id": "DOID:0040085",
    "recommended_name": {
        "id": "DOID:0040085",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0040085",
        "name": "bacterial sepsis",
        "description": "A bacterial infectious disease has_material_basis_in Bacteria."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0040085"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0040085",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0040085",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q9JKE2-1",
            "uniprot_ac": "Q9JKE2",
            "uniprot_id": "TREM1_MOUSE",
            "refseq_ac": "NP_067381",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Triggering receptor expressed on myeloid cells 1",
                    "type": "recommended"
                },
                {
                    "name": "TREM-1",
                    "type": "synonym"
                },
                {
                    "name": "triggering receptor expressed in monocytes 1",
                    "type": "synonym"
                },
                {
                    "name": "triggering receptor expressed on myeloid cells 1 isoform 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trem1",
                    "type": "recommended"
                },
                {
                    "name": "Trem1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9JKE2-1",
            "evidence": [
                {
                    "id": "0040085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0040085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35660-1",
            "uniprot_ac": "O35660",
            "uniprot_id": "GSTM6_MOUSE",
            "refseq_ac": "NP_032210",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Glutathione S-transferase Mu 6",
                    "type": "recommended"
                },
                {
                    "name": "2.5.1.18",
                    "type": "synonym"
                },
                {
                    "name": "GST class-mu 6",
                    "type": "synonym"
                },
                {
                    "name": "Glutathione-S-transferase class M5",
                    "type": "synonym"
                },
                {
                    "name": "glutathione S-transferase Mu 6 isoform 4",
                    "type": "synonym"
                },
                {
                    "name": "glutathione S-transferase Mu 6",
                    "type": "synonym"
                },
                {
                    "name": "glutathione-S-transferase class M5",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Gstm6",
                    "type": "recommended"
                },
                {
                    "name": "Gstm5",
                    "type": "synonym"
                },
                {
                    "name": "Gstm6",
                    "type": "synonym"
                }
            ],
            "record_id": "O35660-1",
            "evidence": [
                {
                    "id": "0040085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0040085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D4ABU7-1",
            "uniprot_ac": "D4ABU7",
            "uniprot_id": "D4ABU7_RAT",
            "refseq_ac": "NP_001100355",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Triggering receptor expressed on myeloid cells 1",
                    "type": "recommended"
                },
                {
                    "name": "triggering receptor expressed on myeloid cells 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Trem1",
                    "type": "recommended"
                },
                {
                    "name": "Trem1",
                    "type": "synonym"
                }
            ],
            "record_id": "D4ABU7-1",
            "evidence": [
                {
                    "id": "0040085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0040085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NP99-1",
            "uniprot_ac": "Q9NP99",
            "uniprot_id": "TREM1_HUMAN",
            "refseq_ac": "NP_001229518",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Triggering receptor expressed on myeloid cells 1",
                    "type": "recommended"
                },
                {
                    "name": "TREM-1",
                    "type": "synonym"
                },
                {
                    "name": "Triggering receptor expressed on monocytes 1",
                    "type": "synonym"
                },
                {
                    "name": "triggering receptor expressed on monocytes 1",
                    "type": "synonym"
                },
                {
                    "name": "triggering receptor expressed on myeloid cells 1 isoform 2 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TREM1",
                    "type": "recommended"
                },
                {
                    "name": "CD354",
                    "type": "synonym"
                },
                {
                    "name": "TREM-1",
                    "type": "synonym"
                },
                {
                    "name": "TREM1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9NP99-1",
            "evidence": [
                {
                    "id": "0040085",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0040085"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P05231-1",
            "uniprot_ac": "P05231",
            "uniprot_id": "IL6_HUMAN",
            "refseq_ac": "NP_000591",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-6",
                    "type": "recommended"
                },
                {
                    "name": "B-cell differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "B-cell stimulatory factor 2",
                    "type": "synonym"
                },
                {
                    "name": "BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "CDF",
                    "type": "synonym"
                },
                {
                    "name": "CTL differentiation factor",
                    "type": "synonym"
                },
                {
                    "name": "Hybridoma growth factor",
                    "type": "synonym"
                },
                {
                    "name": "IFN-beta-2",
                    "type": "synonym"
                },
                {
                    "name": "IL-6",
                    "type": "synonym"
                },
                {
                    "name": "Interferon beta-2",
                    "type": "synonym"
                },
                {
                    "name": "hybridoma growth factor",
                    "type": "synonym"
                },
                {
                    "name": "interferon beta-2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-6 isoform 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IL6",
                    "type": "recommended"
                },
                {
                    "name": "BSF-2",
                    "type": "synonym"
                },
                {
                    "name": "BSF2",
                    "type": "synonym"
                },
                {
                    "name": "CDF",
                    "type": "synonym"
                },
                {
                    "name": "HGF",
                    "type": "synonym"
                },
                {
                    "name": "HSF",
                    "type": "synonym"
                },
                {
                    "name": "IFN-beta-2",
                    "type": "synonym"
                },
                {
                    "name": "IFNB2",
                    "type": "synonym"
                },
                {
                    "name": "IL-6",
                    "type": "synonym"
                },
                {
                    "name": "IL6",
                    "type": "synonym"
                }
            ],
            "record_id": "P05231-1",
            "evidence": [
                {
                    "id": "32479790",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32479790"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [
        {
            "biomarker_id": "AN6278-7",
            "biomarker_canonical_id": "AN6278",
            "best_biomarker_role": [
                {
                    "role": "diagnostic"
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Interleukin-6",
                        "synonyms": [
                            {
                                "synonym": "Interferon beta-2"
                            },
                            {
                                "synonym": "IFN-beta-2"
                            },
                            {
                                "synonym": "CTL differentiation factor"
                            },
                            {
                                "synonym": "CDF"
                            },
                            {
                                "synonym": "B-cell stimulatory factor 2"
                            },
                            {
                                "synonym": "BSF-2"
                            },
                            {
                                "synonym": "Hybridoma growth factor"
                            }
                        ]
                    },
                    "biomarker": "increased IL6 level",
                    "assessed_biomarker_entity_id": "P05231-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "32479790",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/32479790"
                }
            ]
        }
    ],
    "association_flag": "1010",
    "record_id": "doid.0040085"
}