{
    "disease_id": "DOID:0111212",
    "recommended_name": {
        "id": "DOID:0111212",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0111212",
        "name": "autosomal dominant distal hereditary motor neuronopathy 9",
        "description": "An autosomal domiant distal hereditary motor neuronopathy that is characterized by juvenile onset of slowly progressive distal muscle weakness and atrophy affecting both the lower and upper limbs that has_material_basis_in heterozygous mutation in the WARS gene on 14q32.2."
    },
    "synonyms": [
        {
            "id": "DOID:0111212",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111212",
            "name": "DHMN9",
            "description": ""
        },
        {
            "id": "DOID:0111212",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111212",
            "name": "HMN9",
            "description": ""
        },
        {
            "id": "DOID:0111212",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111212",
            "name": "distal hereditary motor neuropathy type IX",
            "description": ""
        },
        {
            "id": "DOID:0111212",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111212",
            "name": "distal hereditary motor neuronopathy type 9",
            "description": ""
        },
        {
            "id": "MONDO:0060585",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0060585",
            "name": "neuronopathy, distal hereditary motor, type 9",
            "description": ""
        },
        {
            "id": "MONDO:0060585",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0060585",
            "name": "HMN9",
            "description": ""
        },
        {
            "id": "MIM:617721",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/617721",
            "name": "Neuronopathy, distal hereditary motor, autosomal dominant 9",
            "description": "Neuronopathy, distal hereditary motor, autosomal dominant 9"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0111212"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0111212",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0111212",
            "categories": []
        },
        {
            "id": "MONDO:0060585",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0060585",
            "categories": []
        },
        {
            "id": "MIM:617721",
            "database": "MIM",
            "url": "https://www.omim.org/entry/617721",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q6PBS3-1",
            "uniprot_ac": "Q6PBS3",
            "uniprot_id": "SYWC_DANRE",
            "refseq_ac": "NP_957066",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "wars",
                    "type": "recommended"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "wars1",
                    "type": "synonym"
                },
                {
                    "name": "wars",
                    "type": "synonym"
                },
                {
                    "name": "zgc:73274",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6PBS3-1",
            "evidence": [
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P32921-1",
            "uniprot_ac": "P32921",
            "uniprot_id": "SYWC_MOUSE",
            "refseq_ac": "NP_001157786",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic",
                    "type": "synonym"
                },
                {
                    "name": "tryptophanyl-tRNA synthetase, cytoplasmic",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Wars1",
                    "type": "recommended"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "WRS",
                    "type": "synonym"
                },
                {
                    "name": "Wars1",
                    "type": "synonym"
                },
                {
                    "name": "Wars",
                    "type": "synonym"
                },
                {
                    "name": "Wrs",
                    "type": "synonym"
                }
            ],
            "record_id": "P32921-1",
            "evidence": [
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P23381-1",
            "uniprot_ac": "P23381",
            "uniprot_id": "SYWC_HUMAN",
            "refseq_ac": "NP_004175",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "IFP53",
                    "type": "synonym"
                },
                {
                    "name": "Interferon-induced protein 53",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory sperm binding protein",
                    "type": "synonym"
                },
                {
                    "name": "hWRS",
                    "type": "synonym"
                },
                {
                    "name": "interferon-induced protein 53",
                    "type": "synonym"
                },
                {
                    "name": "trpRS",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan tRNA ligase 1, cytoplasmic",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic isoform a",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase, cytoplasmic",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "WARS1",
                    "type": "recommended"
                },
                {
                    "name": "GAMMA-2",
                    "type": "synonym"
                },
                {
                    "name": "HMN9",
                    "type": "synonym"
                },
                {
                    "name": "HMND9",
                    "type": "synonym"
                },
                {
                    "name": "IFI53",
                    "type": "synonym"
                },
                {
                    "name": "IFP53",
                    "type": "synonym"
                },
                {
                    "name": "NEDMSBA",
                    "type": "synonym"
                },
                {
                    "name": "WARS1",
                    "type": "synonym"
                },
                {
                    "name": "WARS",
                    "type": "synonym"
                },
                {
                    "name": "WRS",
                    "type": "synonym"
                }
            ],
            "record_id": "P23381-1",
            "evidence": [
                {
                    "id": "617721",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/617721"
                },
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q12109-1",
            "uniprot_ac": "Q12109",
            "uniprot_id": "SYWC_YEAST",
            "refseq_ac": "NP_014544",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                },
                {
                    "name": "tryptophan--tRNA ligase WRS1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "WRS1",
                    "type": "recommended"
                },
                {
                    "name": "HRE342",
                    "type": "synonym"
                },
                {
                    "name": "HRE432",
                    "type": "synonym"
                },
                {
                    "name": "WRS1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q12109-1",
            "evidence": [
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q6P7B0-1",
            "uniprot_ac": "Q6P7B0",
            "uniprot_id": "SYWC_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Wars1",
                    "type": "recommended"
                },
                {
                    "name": "Wars",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6P7B0-1",
            "evidence": [
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q0KI98-1",
            "uniprot_ac": "Q0KI98",
            "uniprot_id": "Q0KI98_DROME",
            "refseq_ac": "NP_524826",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tryptophan--tRNA ligase, cytoplasmic",
                    "type": "recommended"
                },
                {
                    "name": "6.1.1.2",
                    "type": "synonym"
                },
                {
                    "name": "CG9735-PB",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS-PB",
                    "type": "synonym"
                },
                {
                    "name": "Tryptophanyl-tRNA synthetase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TrpRS",
                    "type": "recommended"
                },
                {
                    "name": "85D-WRS",
                    "type": "synonym"
                },
                {
                    "name": "Aats-trp",
                    "type": "synonym"
                },
                {
                    "name": "CG9735",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9735",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG9735",
                    "type": "synonym"
                },
                {
                    "name": "TrpRS",
                    "type": "synonym"
                },
                {
                    "name": "WRS-85D",
                    "type": "synonym"
                },
                {
                    "name": "WRS",
                    "type": "synonym"
                },
                {
                    "name": "dWARS",
                    "type": "synonym"
                },
                {
                    "name": "l(3)03559",
                    "type": "synonym"
                },
                {
                    "name": "l(3)03560",
                    "type": "synonym"
                },
                {
                    "name": "l(3)3559",
                    "type": "synonym"
                },
                {
                    "name": "wars",
                    "type": "synonym"
                }
            ],
            "record_id": "Q0KI98-1",
            "evidence": [
                {
                    "id": "0111212",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111212"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0111212"
}