{
    "disease_id": "DOID:0110909",
    "recommended_name": {
        "id": "DOID:0110909",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110909",
        "name": "inflammatory bowel disease 25",
        "description": "An inflammatory bowel disease characterized by autosomal recessive inheritance that has_material_basis_in homozygous mutation in the IL10RB gene on chromosome 21q22."
    },
    "synonyms": [
        {
            "id": "DOID:0110909",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110909",
            "name": "IBD25",
            "description": ""
        },
        {
            "id": "DOID:0110909",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110909",
            "name": "early onset autosomal recessive inflammatory bowel disease 25",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "inflammatory bowel disease 25",
            "description": "Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene."
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "IBD25",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "IL10RB inflammatory bowel disease",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "inflammatory bowel disease 25, early onset, autosomal recessive",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "inflammatory bowel disease caused by mutation in IL10RB",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "inflammatory bowel disease type 25",
            "description": ""
        },
        {
            "id": "MONDO:0012941",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "name": "inflammatory bowel disease 25, autosomal recessive",
            "description": ""
        },
        {
            "id": "MIM:612567",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/612567",
            "name": "Inflammatory bowel disease 25, autosomal recessive",
            "description": "Inflammatory bowel disease 25, autosomal recessive"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110909"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110909",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110909",
            "categories": []
        },
        {
            "id": "MONDO:0012941",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012941",
            "categories": []
        },
        {
            "id": "MIM:612567",
            "database": "MIM",
            "url": "https://www.omim.org/entry/612567",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB32TUM6-1",
            "uniprot_ac": "A0AB32TUM6",
            "uniprot_id": "A0AB32TUM6_DANRE",
            "refseq_ac": "XP_068077051",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cytokine receptor family member B15 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "cytokine receptor family member B15 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "crfb15",
                    "type": "recommended"
                },
                {
                    "name": "crfb15",
                    "type": "synonym"
                },
                {
                    "name": "si:ch73-222h13.4",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TUM6-1",
            "evidence": [
                {
                    "id": "0110909",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110909"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q61190-1",
            "uniprot_ac": "Q61190",
            "uniprot_id": "I10R2_MOUSE",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-10 receptor subunit beta",
                    "type": "recommended"
                },
                {
                    "name": "CRF2-4",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor class-II member 4",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor family 2 member 4",
                    "type": "synonym"
                },
                {
                    "name": "IL-10 receptor subunit beta",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R subunit 2",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R subunit beta",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R2",
                    "type": "synonym"
                },
                {
                    "name": "IL-10RB",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-10 receptor subunit 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Il10rb",
                    "type": "recommended"
                },
                {
                    "name": "Crfb4",
                    "type": "synonym"
                }
            ],
            "record_id": "Q61190-1",
            "evidence": [
                {
                    "id": "0110909",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110909"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q08334-1",
            "uniprot_ac": "Q08334",
            "uniprot_id": "I10R2_HUMAN",
            "refseq_ac": "NP_000619",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-10 receptor subunit beta",
                    "type": "recommended"
                },
                {
                    "name": "CRF2-4",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor class-II member 4",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor family 2 member 4",
                    "type": "synonym"
                },
                {
                    "name": "IL-10 receptor subunit beta",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R subunit 2",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R subunit beta",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R2",
                    "type": "synonym"
                },
                {
                    "name": "IL-10RB",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-10 receptor subunit 2",
                    "type": "synonym"
                },
                {
                    "name": "cytokine receptor class-II CRF2-4",
                    "type": "synonym"
                },
                {
                    "name": "cytokine receptor class-II member 4",
                    "type": "synonym"
                },
                {
                    "name": "cytokine receptor family 2 member 4",
                    "type": "synonym"
                },
                {
                    "name": "cytokine receptor family II, member 4",
                    "type": "synonym"
                },
                {
                    "name": "interleukin 10 receptor, beta",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-10 receptor subunit 2",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-10 receptor subunit beta isoform 1 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "IL10RB",
                    "type": "recommended"
                },
                {
                    "name": "CDW210B",
                    "type": "synonym"
                },
                {
                    "name": "CRF2-4",
                    "type": "synonym"
                },
                {
                    "name": "CRFB4",
                    "type": "synonym"
                },
                {
                    "name": "D21S58",
                    "type": "synonym"
                },
                {
                    "name": "D21S66",
                    "type": "synonym"
                },
                {
                    "name": "IBD25",
                    "type": "synonym"
                },
                {
                    "name": "IL-10R2",
                    "type": "synonym"
                },
                {
                    "name": "IL-10RB",
                    "type": "synonym"
                },
                {
                    "name": "IL10RB",
                    "type": "synonym"
                }
            ],
            "record_id": "Q08334-1",
            "evidence": [
                {
                    "id": "612567",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/612567"
                },
                {
                    "id": "0110909",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110909"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "D3ZM36-1",
            "uniprot_ac": "D3ZM36",
            "uniprot_id": "D3ZM36_RAT",
            "refseq_ac": "XP_063126661",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interleukin-10 receptor subunit beta",
                    "type": "recommended"
                },
                {
                    "name": "Coagulation factor III",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor class-II member 4",
                    "type": "synonym"
                },
                {
                    "name": "Cytokine receptor family 2 member 4",
                    "type": "synonym"
                },
                {
                    "name": "Interleukin-10 receptor subunit 2",
                    "type": "synonym"
                },
                {
                    "name": "Tissue factor",
                    "type": "synonym"
                },
                {
                    "name": "interleukin-10 receptor subunit beta isoform X2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Il10rb",
                    "type": "recommended"
                },
                {
                    "name": "Il10rb",
                    "type": "synonym"
                },
                {
                    "name": "RGD1560373",
                    "type": "synonym"
                }
            ],
            "record_id": "D3ZM36-1",
            "evidence": [
                {
                    "id": "0110909",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110909"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110909"
}