{
    "disease_id": "DOID:0110877",
    "recommended_name": {
        "id": "DOID:0110877",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110877",
        "name": "holoprosencephaly 11",
        "description": "A holoprosencephaly that has_material_basis_in heterozygous mutation in the CDON gene on chromosome 11q24."
    },
    "synonyms": [
        {
            "id": "DOID:0110877",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110877",
            "name": "HPE11",
            "description": ""
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "holoprosencephaly 11",
            "description": "Any holoprosencephaly in which the cause of the disease is a mutation in the CDON gene."
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "CDON holoprosencephaly",
            "description": ""
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "HPE11",
            "description": ""
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "holoprosencephaly 11",
            "description": ""
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "holoprosencephaly caused by mutation in CDON",
            "description": ""
        },
        {
            "id": "MONDO:0013642",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "name": "holoprosencephaly type 11",
            "description": ""
        },
        {
            "id": "MIM:614226",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/614226",
            "name": "Holoprosencephaly 11",
            "description": "Holoprosencephaly 11"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110877"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110877",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110877",
            "categories": []
        },
        {
            "id": "MONDO:0013642",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013642",
            "categories": []
        },
        {
            "id": "MIM:614226",
            "database": "MIM",
            "url": "https://www.omim.org/entry/614226",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q32MD9-1",
            "uniprot_ac": "Q32MD9",
            "uniprot_id": "CDON_MOUSE",
            "refseq_ac": "NP_067314",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "recommended"
                },
                {
                    "name": "CAM-related/down-regulated by oncogenes",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes precursor",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "synonym"
                },
                {
                    "name": "immunoglobulin superfamily member CDO",
                    "type": "synonym"
                },
                {
                    "name": "oncogene-regulated cell adhesion molecule",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cdon",
                    "type": "recommended"
                },
                {
                    "name": "CDO",
                    "type": "synonym"
                },
                {
                    "name": "Cd0",
                    "type": "synonym"
                },
                {
                    "name": "Cdon",
                    "type": "synonym"
                },
                {
                    "name": "Cdo",
                    "type": "synonym"
                },
                {
                    "name": "Orcam",
                    "type": "synonym"
                }
            ],
            "record_id": "Q32MD9-1",
            "evidence": [
                {
                    "id": "0110877",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110877"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q4KMG0-1",
            "uniprot_ac": "Q4KMG0",
            "uniprot_id": "CDON_HUMAN",
            "refseq_ac": "NP_001230526",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "recommended"
                },
                {
                    "name": "Cdon homolog",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes isoform 1 precursor",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "synonym"
                },
                {
                    "name": "surface glycoprotein, Ig superfamily member",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CDON",
                    "type": "recommended"
                },
                {
                    "name": "CDON1",
                    "type": "synonym"
                },
                {
                    "name": "CDON",
                    "type": "synonym"
                },
                {
                    "name": "CDO",
                    "type": "synonym"
                },
                {
                    "name": "HPE11",
                    "type": "synonym"
                },
                {
                    "name": "Ihog",
                    "type": "synonym"
                },
                {
                    "name": "ORCAM",
                    "type": "synonym"
                }
            ],
            "record_id": "Q4KMG0-1",
            "evidence": [
                {
                    "id": "614226",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/614226"
                },
                {
                    "id": "0110877",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110877"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O35158-1",
            "uniprot_ac": "O35158",
            "uniprot_id": "CDON_RAT",
            "refseq_ac": "NP_059054",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "recommended"
                },
                {
                    "name": "Cdon homolog",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes precursor",
                    "type": "synonym"
                },
                {
                    "name": "cell adhesion molecule-related/down-regulated by oncogenes",
                    "type": "synonym"
                },
                {
                    "name": "immunoglobulin superfamily member",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Cdon",
                    "type": "recommended"
                },
                {
                    "name": "Cdon",
                    "type": "synonym"
                },
                {
                    "name": "Cdo",
                    "type": "synonym"
                }
            ],
            "record_id": "O35158-1",
            "evidence": [
                {
                    "id": "0110877",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110877"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VM64-1",
            "uniprot_ac": "Q9VM64",
            "uniprot_id": "IHOG_DROME",
            "refseq_ac": "NP_609085",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interference hedgehog",
                    "type": "recommended"
                },
                {
                    "name": "CG9211-PA",
                    "type": "synonym"
                },
                {
                    "name": "ihog-PA",
                    "type": "synonym"
                },
                {
                    "name": "interference hedgehog",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ihog",
                    "type": "recommended"
                },
                {
                    "name": "CG9211",
                    "type": "synonym"
                },
                {
                    "name": "CT26314",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG9211",
                    "type": "synonym"
                },
                {
                    "name": "IHOG",
                    "type": "synonym"
                },
                {
                    "name": "Ihog",
                    "type": "synonym"
                },
                {
                    "name": "iHog",
                    "type": "synonym"
                },
                {
                    "name": "ihog",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VM64-1",
            "evidence": [
                {
                    "id": "0110877",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110877"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A8JUV7-1",
            "uniprot_ac": "A8JUV7",
            "uniprot_id": "A8JUV7_DROME",
            "refseq_ac": "NP_001096868",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Interference hedgehog",
                    "type": "recommended"
                },
                {
                    "name": "CG32796-PG",
                    "type": "synonym"
                },
                {
                    "name": "boi-PG",
                    "type": "synonym"
                },
                {
                    "name": "brother of iHog",
                    "type": "synonym"
                },
                {
                    "name": "brother of ihog, isoform G",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "boi",
                    "type": "recommended"
                },
                {
                    "name": "Boi",
                    "type": "synonym"
                },
                {
                    "name": "CG13756",
                    "type": "synonym"
                },
                {
                    "name": "CG32796",
                    "type": "synonym"
                },
                {
                    "name": "CG7894",
                    "type": "synonym"
                },
                {
                    "name": "CT23737",
                    "type": "synonym"
                },
                {
                    "name": "CT33235",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG32796",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG32796",
                    "type": "synonym"
                },
                {
                    "name": "EG:BACH59J11.2",
                    "type": "synonym"
                },
                {
                    "name": "boi",
                    "type": "synonym"
                }
            ],
            "record_id": "A8JUV7-1",
            "evidence": [
                {
                    "id": "0110877",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110877"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110877"
}