{
    "disease_id": "DOID:0110759",
    "recommended_name": {
        "id": "DOID:0110759",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110759",
        "name": "type 1 diabetes mellitus 22",
        "description": "A type 1 diabetes mellitus that has_material_basis_in mutation of the CCR5 gene on chromosome 3p21.31."
    },
    "synonyms": [
        {
            "id": "DOID:0110759",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110759",
            "name": "IDDM22",
            "description": ""
        },
        {
            "id": "DOID:0110759",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110759",
            "name": "Insulin-Dependent Diabetes Mellitus 22",
            "description": ""
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "type 1 diabetes mellitus 22",
            "description": "An inherited susceptibility or predisposition to developing type 1 diabetes mellitus in which the cause of the disease is a mutation in the CCR5 gene."
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "CCR5 type 1 diabetes mellitus",
            "description": ""
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "IDDM22",
            "description": ""
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "diabetes mellitus, insulin-dependent, type 22",
            "description": ""
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "type 1 diabetes mellitus caused by mutation in CCR5",
            "description": ""
        },
        {
            "id": "MONDO:0012921",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "name": "diabetes mellitus, insulin-dependent, 22",
            "description": ""
        },
        {
            "id": "MIM:612522",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/612522",
            "name": "Type 1 diabetes mellitus 22",
            "description": "Type 1 diabetes mellitus 22"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110759"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110759",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110759",
            "categories": []
        },
        {
            "id": "MONDO:0012921",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012921",
            "categories": []
        },
        {
            "id": "MIM:612522",
            "database": "MIM",
            "url": "https://www.omim.org/entry/612522",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1QYD4-1",
            "uniprot_ac": "F1QYD4",
            "uniprot_id": "F1QYD4_DANRE",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "C-C chemokine receptor type 4-like",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "ccr2",
                    "type": "recommended"
                },
                {
                    "name": "si:ch211-207g17.3",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QYD4-1",
            "evidence": [
                {
                    "id": "0110759",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110759"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P51682-1",
            "uniprot_ac": "P51682",
            "uniprot_id": "CCR5_MOUSE",
            "refseq_ac": "NP_034047",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "recommended"
                },
                {
                    "name": "C-C CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "synonym"
                },
                {
                    "name": "CC-CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCR-5",
                    "type": "synonym"
                },
                {
                    "name": "MIP-1 alpha receptor",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C motif) receptor 5",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C) receptor 5",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ccr5",
                    "type": "recommended"
                },
                {
                    "name": "AM4-7",
                    "type": "synonym"
                },
                {
                    "name": "CD195",
                    "type": "synonym"
                },
                {
                    "name": "Ccr5",
                    "type": "synonym"
                },
                {
                    "name": "Cmkbr5",
                    "type": "synonym"
                }
            ],
            "record_id": "P51682-1",
            "evidence": [
                {
                    "id": "0110759",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110759"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P51681-1",
            "uniprot_ac": "P51681",
            "uniprot_id": "CCR5_HUMAN",
            "refseq_ac": "NP_000570",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "recommended"
                },
                {
                    "name": "C-C CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "synonym"
                },
                {
                    "name": "C-C motif chemokine receptor 5 A159A",
                    "type": "synonym"
                },
                {
                    "name": "CC-CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCR5",
                    "type": "synonym"
                },
                {
                    "name": "CHEMR13",
                    "type": "synonym"
                },
                {
                    "name": "HIV-1 fusion coreceptor",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C motif) receptor 5",
                    "type": "synonym"
                },
                {
                    "name": "chemokine receptor CCR5",
                    "type": "synonym"
                },
                {
                    "name": "chemokine recptor CCR5 Delta32",
                    "type": "synonym"
                },
                {
                    "name": "chemr13",
                    "type": "synonym"
                },
                {
                    "name": "mutant C-C motif chemokine receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CCR5",
                    "type": "recommended"
                },
                {
                    "name": "CC-CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCCKR5",
                    "type": "synonym"
                },
                {
                    "name": "CCR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCR5",
                    "type": "synonym"
                },
                {
                    "name": "CD195",
                    "type": "synonym"
                },
                {
                    "name": "CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "CKR5",
                    "type": "synonym"
                },
                {
                    "name": "CMKBR5",
                    "type": "synonym"
                },
                {
                    "name": "IDDM22",
                    "type": "synonym"
                }
            ],
            "record_id": "P51681-1",
            "evidence": [
                {
                    "id": "612522",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/612522"
                },
                {
                    "id": "0110759",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110759"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O08556-1",
            "uniprot_ac": "O08556",
            "uniprot_id": "CCR5_RAT",
            "refseq_ac": "NP_446412",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "recommended"
                },
                {
                    "name": "C-C CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "C-C chemokine receptor type 5",
                    "type": "synonym"
                },
                {
                    "name": "CC-CKR-5",
                    "type": "synonym"
                },
                {
                    "name": "CCR-5",
                    "type": "synonym"
                },
                {
                    "name": "MIP-1 alpha receptor",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C motif) receptor 5",
                    "type": "synonym"
                },
                {
                    "name": "chemokine (C-C) receptor 5",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Ccr5",
                    "type": "recommended"
                },
                {
                    "name": "Ccr5",
                    "type": "synonym"
                },
                {
                    "name": "Ckr5",
                    "type": "synonym"
                },
                {
                    "name": "Cmkbr5",
                    "type": "synonym"
                }
            ],
            "record_id": "O08556-1",
            "evidence": [
                {
                    "id": "0110759",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110759"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110759"
}