{
    "disease_id": "DOID:0110457",
    "recommended_name": {
        "id": "DOID:0110457",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0110457",
        "name": "dilated cardiomyopathy 1Y",
        "description": "A dilated cardiomyopathy that has_material_basis_in mutation in the TPM1 gene on chromosome 15q22.1."
    },
    "synonyms": [
        {
            "id": "DOID:0110457",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110457",
            "name": "CMD1Y",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "dilated cardiomyopathy 1Y",
            "description": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the TPM1 gene."
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "CMD1Y",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "TPM1 familial isolated dilated cardiomyopathy",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "cardiomyopathy, dilated, type 1Y",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "dilated cardiomyopathy type 1Y",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "familial isolated dilated cardiomyopathy caused by mutation in TPM1",
            "description": ""
        },
        {
            "id": "MONDO:0012744",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "name": "cardiomyopathy, dilated, 1Y",
            "description": ""
        },
        {
            "id": "MIM:611878",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/611878",
            "name": "Cardiomyopathy, dilated, 1Y",
            "description": "Cardiomyopathy, dilated, 1Y"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0110457"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0110457",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0110457",
            "categories": []
        },
        {
            "id": "MONDO:0012744",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0012744",
            "categories": []
        },
        {
            "id": "MIM:611878",
            "database": "MIM",
            "url": "https://www.omim.org/entry/611878",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB32TFB7-1",
            "uniprot_ac": "A0AB32TFB7",
            "uniprot_id": "A0AB32TFB7_DANRE",
            "refseq_ac": "XP_068073447",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin alpha-1 chain isoform X19",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain isoform X19",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "tpm1",
                    "type": "recommended"
                },
                {
                    "name": "TPM1-1",
                    "type": "synonym"
                },
                {
                    "name": "Tm1",
                    "type": "synonym"
                },
                {
                    "name": "tpm1",
                    "type": "synonym"
                },
                {
                    "name": "zgc:171719",
                    "type": "synonym"
                },
                {
                    "name": "zgc:55951",
                    "type": "synonym"
                },
                {
                    "name": "zgc:77009",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32TFB7-1",
            "evidence": [
                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P13104-1",
            "uniprot_ac": "P13104",
            "uniprot_id": "TPM1_DANRE",
            "refseq_ac": "NP_571180",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin alpha-1 chain",
                    "type": "recommended"
                },
                {
                    "name": "Alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "TPM1-2 alpha",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-1",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 1-2 nu",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "tpma",
                    "type": "recommended"
                },
                {
                    "name": "TPM1",
                    "type": "synonym"
                },
                {
                    "name": "fb37a09",
                    "type": "synonym"
                },
                {
                    "name": "tm",
                    "type": "synonym"
                },
                {
                    "name": "tpm1",
                    "type": "synonym"
                },
                {
                    "name": "tpma",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb37a09",
                    "type": "synonym"
                }
            ],
            "record_id": "P13104-1",
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                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P58771-1",
            "uniprot_ac": "P58771",
            "uniprot_id": "TPM1_MOUSE",
            "refseq_ac": "NP_001157720",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin alpha-1 chain",
                    "type": "recommended"
                },
                {
                    "name": "Alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-1",
                    "type": "synonym"
                },
                {
                    "name": "alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 1 kappa",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain isoform Tpm1.1st",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin-1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tpm1",
                    "type": "recommended"
                },
                {
                    "name": "TM2",
                    "type": "synonym"
                },
                {
                    "name": "TPM1kappa",
                    "type": "synonym"
                },
                {
                    "name": "Tm3",
                    "type": "synonym"
                },
                {
                    "name": "Tmpa",
                    "type": "synonym"
                },
                {
                    "name": "Tpm-1",
                    "type": "synonym"
                },
                {
                    "name": "Tpm1",
                    "type": "synonym"
                },
                {
                    "name": "Tpma",
                    "type": "synonym"
                },
                {
                    "name": "alpha-TM",
                    "type": "synonym"
                }
            ],
            "record_id": "P58771-1",
            "evidence": [
                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P09493-1",
            "uniprot_ac": "P09493",
            "uniprot_id": "TPM1_HUMAN",
            "refseq_ac": "NP_000357",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin alpha-1 chain",
                    "type": "recommended"
                },
                {
                    "name": "Alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-1",
                    "type": "synonym"
                },
                {
                    "name": "cardiomyopathy, hypertrophic 3",
                    "type": "synonym"
                },
                {
                    "name": "epididymis secretory protein Li 265",
                    "type": "synonym"
                },
                {
                    "name": "sarcomeric tropomyosin kappa",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain isoform Tpm1.5cy",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TPM1",
                    "type": "recommended"
                },
                {
                    "name": "C15orf13",
                    "type": "synonym"
                },
                {
                    "name": "CMD1Y",
                    "type": "synonym"
                },
                {
                    "name": "CMH3",
                    "type": "synonym"
                },
                {
                    "name": "HEL-S-265",
                    "type": "synonym"
                },
                {
                    "name": "HTM-alpha",
                    "type": "synonym"
                },
                {
                    "name": "LVNC9",
                    "type": "synonym"
                },
                {
                    "name": "TMSA",
                    "type": "synonym"
                },
                {
                    "name": "TPM1",
                    "type": "synonym"
                }
            ],
            "record_id": "P09493-1",
            "evidence": [
                {
                    "id": "611878",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/611878"
                },
                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P17536-1",
            "uniprot_ac": "P17536",
            "uniprot_id": "TPM1_YEAST",
            "refseq_ac": "NP_014320",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin-1",
                    "type": "recommended"
                },
                {
                    "name": "tropomyosin TPM1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TPM1",
                    "type": "recommended"
                },
                {
                    "name": "N2332",
                    "type": "synonym"
                },
                {
                    "name": "TPM1",
                    "type": "synonym"
                }
            ],
            "record_id": "P17536-1",
            "evidence": [
                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P04692-1",
            "uniprot_ac": "P04692",
            "uniprot_id": "TPM1_RAT",
            "refseq_ac": "NP_001029241",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin alpha-1 chain",
                    "type": "recommended"
                },
                {
                    "name": "Alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-1",
                    "type": "synonym"
                },
                {
                    "name": "hepatoma alpha tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "smooth muscle alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "striated muscle alpha-tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 1, alpha",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 3 alpha",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin alpha-1 chain isoform Tpm1.6cy",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin-alpha",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tpm1",
                    "type": "recommended"
                },
                {
                    "name": "Alpha-tm",
                    "type": "synonym"
                },
                {
                    "name": "Tma2",
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                },
                {
                    "name": "Tmsa",
                    "type": "synonym"
                },
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                    "name": "Tpm1",
                    "type": "synonym"
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                    "id": "0110457",
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                }
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            "uniprot_canonical_ac": "P09491-1",
            "uniprot_ac": "P09491",
            "uniprot_id": "TPM2_DROME",
            "refseq_ac": "NP_001262592",
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            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
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                    "name": "Tropomyosin-2",
                    "type": "recommended"
                },
                {
                    "name": "CG4843-PF",
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                },
                {
                    "name": "Tm2-PF",
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                },
                {
                    "name": "Tropomyosin I",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-2",
                    "type": "synonym"
                },
                {
                    "name": "lethal(3)nc99Eb",
                    "type": "synonym"
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                {
                    "name": "tropomyosin 127",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 2, isoform F",
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                {
                    "name": "tropomyosin I",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin2",
                    "type": "synonym"
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                    "name": "Tm2",
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                    "name": "CG4843",
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                },
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                    "name": "DROTROPI1",
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                },
                {
                    "name": "Dmel\\CG4843",
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                    "name": "Dmel_CG4843",
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                },
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                    "name": "IP16005p",
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                },
                {
                    "name": "Ifm(3)3",
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                },
                {
                    "name": "Ifm(3)5",
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                    "name": "Ifm-TmI",
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                {
                    "name": "TM2",
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                {
                    "name": "Tm127",
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                {
                    "name": "Tm2",
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                {
                    "name": "TmII",
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                {
                    "name": "TmI",
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                },
                {
                    "name": "Tm",
                    "type": "synonym"
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                {
                    "name": "Tn-H",
                    "type": "synonym"
                },
                {
                    "name": "dro Tm",
                    "type": "synonym"
                },
                {
                    "name": "l(3)nc99Eb",
                    "type": "synonym"
                },
                {
                    "name": "mTmI",
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                }
            ],
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                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
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        {
            "uniprot_canonical_ac": "P49455-1",
            "uniprot_ac": "P49455",
            "uniprot_id": "TPM4_DROME",
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            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Tropomyosin-1, isoforms 33/34",
                    "type": "recommended"
                },
                {
                    "name": "CG4898-PF",
                    "type": "synonym"
                },
                {
                    "name": "Tm1-PF",
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                },
                {
                    "name": "Tropomyosin II",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin-1",
                    "type": "synonym"
                },
                {
                    "name": "Tropomyosin1",
                    "type": "synonym"
                },
                {
                    "name": "cytoplasmic tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "cytoskeletal tropomyosin",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin 1, isoform F",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin II",
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                },
                {
                    "name": "tropomyosin I",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosinII",
                    "type": "synonym"
                },
                {
                    "name": "tropomysin II",
                    "type": "synonym"
                },
                {
                    "name": "troponin H",
                    "type": "synonym"
                },
                {
                    "name": "troponin-H isoform 34",
                    "type": "synonym"
                }
            ],
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                    "name": "Tm1",
                    "type": "recommended"
                },
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                    "name": "10",
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                },
                {
                    "name": "1305/10",
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                {
                    "name": "2299",
                    "type": "synonym"
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                {
                    "name": "BcDNA:GH09289",
                    "type": "synonym"
                },
                {
                    "name": "BcDNA:LD37158",
                    "type": "synonym"
                },
                {
                    "name": "BcDNA:SD21996",
                    "type": "synonym"
                },
                {
                    "name": "CG4898",
                    "type": "synonym"
                },
                {
                    "name": "Dm Tm1",
                    "type": "synonym"
                },
                {
                    "name": "Dm TmH33",
                    "type": "synonym"
                },
                {
                    "name": "Dm TmH34",
                    "type": "synonym"
                },
                {
                    "name": "DmTm1",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG4898",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG4898",
                    "type": "synonym"
                },
                {
                    "name": "PmI",
                    "type": "synonym"
                },
                {
                    "name": "TM1",
                    "type": "synonym"
                },
                {
                    "name": "TMII",
                    "type": "synonym"
                },
                {
                    "name": "TM",
                    "type": "synonym"
                },
                {
                    "name": "Tm1",
                    "type": "synonym"
                },
                {
                    "name": "TmH-33",
                    "type": "synonym"
                },
                {
                    "name": "TmH-34",
                    "type": "synonym"
                },
                {
                    "name": "TmH33",
                    "type": "synonym"
                },
                {
                    "name": "TmH34",
                    "type": "synonym"
                },
                {
                    "name": "TmH",
                    "type": "synonym"
                },
                {
                    "name": "TmII",
                    "type": "synonym"
                },
                {
                    "name": "Tmr33",
                    "type": "synonym"
                },
                {
                    "name": "Tmr34",
                    "type": "synonym"
                },
                {
                    "name": "Tm",
                    "type": "synonym"
                },
                {
                    "name": "TnH-33",
                    "type": "synonym"
                },
                {
                    "name": "TnH-34",
                    "type": "synonym"
                },
                {
                    "name": "TnH",
                    "type": "synonym"
                },
                {
                    "name": "cTM",
                    "type": "synonym"
                },
                {
                    "name": "cTmII",
                    "type": "synonym"
                },
                {
                    "name": "cTm",
                    "type": "synonym"
                },
                {
                    "name": "chr3R:11122272..11122408",
                    "type": "synonym"
                },
                {
                    "name": "l(3)02299",
                    "type": "synonym"
                },
                {
                    "name": "l(3)S130510",
                    "type": "synonym"
                },
                {
                    "name": "l(3)s2958",
                    "type": "synonym"
                },
                {
                    "name": "mTmII",
                    "type": "synonym"
                },
                {
                    "name": "region 3",
                    "type": "synonym"
                },
                {
                    "name": "tm1",
                    "type": "synonym"
                },
                {
                    "name": "tmII",
                    "type": "synonym"
                },
                {
                    "name": "tropomyosin",
                    "type": "synonym"
                }
            ],
            "record_id": "P49455-1",
            "evidence": [
                {
                    "id": "0110457",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110457"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0110457"
}