{
    "disease_id": "DOID:0081012",
    "recommended_name": {
        "id": "DOID:0081012",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0081012",
        "name": "critical COVID-19",
        "description": "A COVID-19 that is characterized by the criteria for acute respiratory distress syndrome (ARDS), sepsis, septic shock, or other conditions that would normally require the provision of life sustaining therapies such as mechanical ventilation (invasive or non-invasive) or vasopressor therapy."
    },
    "synonyms": [],
    "children": [],
    "id_list": [
        "DOID:0081012"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0081012",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0081012",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q99MB1-1",
            "uniprot_ac": "Q99MB1",
            "uniprot_id": "TLR3_MOUSE",
            "refseq_ac": "NP_569054",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr3",
                    "type": "recommended"
                },
                {
                    "name": "Tlr3",
                    "type": "synonym"
                }
            ],
            "record_id": "Q99MB1-1",
            "evidence": [
                {
                    "id": "0081012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F1LN63-1",
            "uniprot_ac": "F1LN63",
            "uniprot_id": "F1LN63_RAT",
            "refseq_ac": "NP_942086",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Tlr3",
                    "type": "recommended"
                },
                {
                    "name": "Tlr3",
                    "type": "synonym"
                }
            ],
            "record_id": "F1LN63-1",
            "evidence": [
                {
                    "id": "0081012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VPH1-1",
            "uniprot_ac": "Q9VPH1",
            "uniprot_id": "Q9VPH1_DROME",
            "refseq_ac": "NP_001246846",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG5528-PC",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9-PC",
                    "type": "synonym"
                },
                {
                    "name": "toll receptor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Toll-9",
                    "type": "recommended"
                },
                {
                    "name": "CG5528",
                    "type": "synonym"
                },
                {
                    "name": "CT17508",
                    "type": "synonym"
                },
                {
                    "name": "Dm Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG5528",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG5528",
                    "type": "synonym"
                },
                {
                    "name": "TOLL 9",
                    "type": "synonym"
                },
                {
                    "name": "Tak/Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Tl-5",
                    "type": "synonym"
                },
                {
                    "name": "Tl-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll 9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-6",
                    "type": "synonym"
                },
                {
                    "name": "Toll-9",
                    "type": "synonym"
                },
                {
                    "name": "Toll-like",
                    "type": "synonym"
                },
                {
                    "name": "Toll9",
                    "type": "synonym"
                },
                {
                    "name": "Toll",
                    "type": "synonym"
                },
                {
                    "name": "dTLR9",
                    "type": "synonym"
                },
                {
                    "name": "dToll9",
                    "type": "synonym"
                },
                {
                    "name": "toll",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VPH1-1",
            "evidence": [
                {
                    "id": "0081012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081012"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O15455-1",
            "uniprot_ac": "O15455",
            "uniprot_id": "TLR3_HUMAN",
            "refseq_ac": "NP_003256",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Toll-like receptor 3",
                    "type": "recommended"
                },
                {
                    "name": "toll-like receptor 3 precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "TLR3",
                    "type": "recommended"
                },
                {
                    "name": "CD283",
                    "type": "synonym"
                },
                {
                    "name": "IIAE2",
                    "type": "synonym"
                },
                {
                    "name": "IMD83",
                    "type": "synonym"
                },
                {
                    "name": "TLR3",
                    "type": "synonym"
                }
            ],
            "record_id": "O15455-1",
            "evidence": [
                {
                    "id": "0081012",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0081012"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0081012"
}