{
    "disease_id": "DOID:0080663",
    "recommended_name": {
        "id": "DOID:0080663",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0080663",
        "name": "atrial standstill 2",
        "description": "A heart conduction disease that is characterized by a transient or permanent absence of electrical and mechanical atrial activity and has_material_basis_in homozygous mutation in the NPPA gene on chromosome 1p36."
    },
    "synonyms": [
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "atrial standstill 2",
            "description": "Any atrial standstill in which the cause of the disease is a mutation in the NPPA gene."
        },
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "NPPA atrial standstill",
            "description": ""
        },
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "atrial standstill 2",
            "description": ""
        },
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "atrial standstill caused by mutation in NPPA",
            "description": ""
        },
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "atrial standstill type 2",
            "description": ""
        },
        {
            "id": "MONDO:0014329",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "name": "ATRST2",
            "description": ""
        },
        {
            "id": "MIM:615745",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/615745",
            "name": "Atrial standstill 2",
            "description": "Atrial standstill 2"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0080663"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0080663",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0080663",
            "categories": []
        },
        {
            "id": "MONDO:0014329",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0014329",
            "categories": []
        },
        {
            "id": "MIM:615745",
            "database": "MIM",
            "url": "https://www.omim.org/entry/615745",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1QVW0-1",
            "uniprot_ac": "F1QVW0",
            "uniprot_id": "F1QVW0_DANRE",
            "refseq_ac": "NP_942095",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natriuretic peptides A precursor",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic factor",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptide precursor A",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "nppa",
                    "type": "recommended"
                },
                {
                    "name": "anf",
                    "type": "synonym"
                },
                {
                    "name": "anp",
                    "type": "synonym"
                },
                {
                    "name": "hm:zeh1304",
                    "type": "synonym"
                },
                {
                    "name": "nppa",
                    "type": "synonym"
                },
                {
                    "name": "zeh1304",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QVW0-1",
            "evidence": [
                {
                    "id": "0080663",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080663"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P05125-1",
            "uniprot_ac": "P05125",
            "uniprot_id": "ANF_MOUSE",
            "refseq_ac": "NP_032751",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natriuretic peptides A",
                    "type": "recommended"
                },
                {
                    "name": "ANF 1-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 3-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 8-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-atrial natriuretic peptide",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-hANP",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 1-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 3-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 8-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin III",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin II",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin I",
                    "type": "synonym"
                },
                {
                    "name": "CDD 95-126",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (95-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (99-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "Cardiodilatin",
                    "type": "synonym"
                },
                {
                    "name": "Cardionatrin",
                    "type": "synonym"
                },
                {
                    "name": "LANH",
                    "type": "synonym"
                },
                {
                    "name": "Long-acting natriuretic hormone",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 99-126",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 95-126",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "cardiodilatin",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptide precursor type A",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A",
                    "type": "synonym"
                },
                {
                    "name": "preproANF",
                    "type": "synonym"
                },
                {
                    "name": "preproANP",
                    "type": "synonym"
                },
                {
                    "name": "preproCDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "prepronatriodilatin",
                    "type": "synonym"
                },
                {
                    "name": "proANF 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANF 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANF 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANF 99-126",
                    "type": "synonym"
                },
                {
                    "name": "proANF",
                    "type": "synonym"
                },
                {
                    "name": "proANP 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANP 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANP 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANP 95-126",
                    "type": "synonym"
                },
                {
                    "name": "proANP",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nppa",
                    "type": "recommended"
                },
                {
                    "name": "ANP",
                    "type": "synonym"
                },
                {
                    "name": "Anf",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "Nppa",
                    "type": "synonym"
                },
                {
                    "name": "Pnd",
                    "type": "synonym"
                }
            ],
            "record_id": "P05125-1",
            "evidence": [
                {
                    "id": "0080663",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080663"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01160-1",
            "uniprot_ac": "P01160",
            "uniprot_id": "ANF_HUMAN",
            "refseq_ac": "NP_006163",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natriuretic peptides A",
                    "type": "recommended"
                },
                {
                    "name": "ANF 1-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 3-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 8-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-atrial natriuretic peptide",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-hANP",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 1-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 3-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 8-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin III",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin II",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin I",
                    "type": "synonym"
                },
                {
                    "name": "CDD 95-126",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (95-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (99-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "Cardiodilatin",
                    "type": "synonym"
                },
                {
                    "name": "Cardionatrin",
                    "type": "synonym"
                },
                {
                    "name": "LANH",
                    "type": "synonym"
                },
                {
                    "name": "Long-acting natriuretic hormone",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 99-126",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 95-126",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "atriopeptin",
                    "type": "synonym"
                },
                {
                    "name": "cardiodilatin-related peptide",
                    "type": "synonym"
                },
                {
                    "name": "cardionatrin",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptide precursor A",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A preproprotein",
                    "type": "synonym"
                },
                {
                    "name": "preproANP",
                    "type": "synonym"
                },
                {
                    "name": "preproCDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "prepronatriodilatin",
                    "type": "synonym"
                },
                {
                    "name": "proANF 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANF 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANF 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANF 99-126",
                    "type": "synonym"
                },
                {
                    "name": "proANF",
                    "type": "synonym"
                },
                {
                    "name": "proANP 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANP 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANP 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANP 95-126",
                    "type": "synonym"
                },
                {
                    "name": "proANP",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "NPPA",
                    "type": "recommended"
                },
                {
                    "name": "ANF",
                    "type": "synonym"
                },
                {
                    "name": "ANP",
                    "type": "synonym"
                },
                {
                    "name": "ATFB6",
                    "type": "synonym"
                },
                {
                    "name": "ATRST2",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "CDP",
                    "type": "synonym"
                },
                {
                    "name": "NPPA",
                    "type": "synonym"
                },
                {
                    "name": "PND",
                    "type": "synonym"
                }
            ],
            "record_id": "P01160-1",
            "evidence": [
                {
                    "id": "615745",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/615745"
                },
                {
                    "id": "0080663",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080663"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P01161-1",
            "uniprot_ac": "P01161",
            "uniprot_id": "ANF_RAT",
            "refseq_ac": "NP_036744",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Natriuretic peptides A",
                    "type": "recommended"
                },
                {
                    "name": "ANF 1-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 3-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF 8-33",
                    "type": "synonym"
                },
                {
                    "name": "ANF",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-atrial natriuretic peptide",
                    "type": "synonym"
                },
                {
                    "name": "Alpha-hANP",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 1-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 3-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor 8-33",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic factor",
                    "type": "synonym"
                },
                {
                    "name": "Atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin III",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin II",
                    "type": "synonym"
                },
                {
                    "name": "Atriopeptin I",
                    "type": "synonym"
                },
                {
                    "name": "CDD 95-126",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (95-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD-ANP (99-126)",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "Cardiodilatin",
                    "type": "synonym"
                },
                {
                    "name": "Cardionatrin",
                    "type": "synonym"
                },
                {
                    "name": "LANH",
                    "type": "synonym"
                },
                {
                    "name": "Long-acting natriuretic hormone",
                    "type": "synonym"
                },
                {
                    "name": "Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd)",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic factor 99-126",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 1-30",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 31-67",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 79-98",
                    "type": "synonym"
                },
                {
                    "name": "Pro atrial natriuretic peptide 95-126",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic factor prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atrial natriuretic peptide prohormone",
                    "type": "synonym"
                },
                {
                    "name": "atriopeptigen",
                    "type": "synonym"
                },
                {
                    "name": "cardiodilatin",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptide precursor type A",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A precursor",
                    "type": "synonym"
                },
                {
                    "name": "natriuretic peptides A",
                    "type": "synonym"
                },
                {
                    "name": "preproANF",
                    "type": "synonym"
                },
                {
                    "name": "preproANP",
                    "type": "synonym"
                },
                {
                    "name": "preproCDD-ANF",
                    "type": "synonym"
                },
                {
                    "name": "prepronatriodilatin",
                    "type": "synonym"
                },
                {
                    "name": "proANF 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANF 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANF 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANF 99-126",
                    "type": "synonym"
                },
                {
                    "name": "proANF",
                    "type": "synonym"
                },
                {
                    "name": "proANP 1-30",
                    "type": "synonym"
                },
                {
                    "name": "proANP 31-67",
                    "type": "synonym"
                },
                {
                    "name": "proANP 79-98",
                    "type": "synonym"
                },
                {
                    "name": "proANP 95-126",
                    "type": "synonym"
                },
                {
                    "name": "proANP",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Nppa",
                    "type": "recommended"
                },
                {
                    "name": "ANF",
                    "type": "synonym"
                },
                {
                    "name": "ANP",
                    "type": "synonym"
                },
                {
                    "name": "CDD",
                    "type": "synonym"
                },
                {
                    "name": "Nppa",
                    "type": "synonym"
                },
                {
                    "name": "Pnd",
                    "type": "synonym"
                },
                {
                    "name": "RATANF",
                    "type": "synonym"
                }
            ],
            "record_id": "P01161-1",
            "evidence": [
                {
                    "id": "0080663",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0080663"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0080663"
}