{
    "disease_id": "DOID:0070450",
    "recommended_name": {
        "id": "DOID:0070450",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070450",
        "name": "mitochondrial DNA depletion syndrome 19",
        "description": "A mitochondrial DNA depletion syndrome that has_material_basis_in compound heterozygous mutation in the SLC25A10 gene on chromosome 17q25.3."
    },
    "synonyms": [
        {
            "id": "MONDO:0033545",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0033545",
            "name": "mitochondrial DNA depletion syndrome 19",
            "description": ""
        },
        {
            "id": "MONDO:0033545",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0033545",
            "name": "MTDPS19",
            "description": ""
        },
        {
            "id": "MIM:618972",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/618972",
            "name": "Mitochondrial DNA depletion syndrome 19",
            "description": "Mitochondrial DNA depletion syndrome 19"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070450"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070450",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070450",
            "categories": []
        },
        {
            "id": "MONDO:0033545",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0033545",
            "categories": []
        },
        {
            "id": "MIM:618972",
            "database": "MIM",
            "url": "https://www.omim.org/entry/618972",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "F1QDE0-1",
            "uniprot_ac": "F1QDE0",
            "uniprot_id": "F1QDE0_DANRE",
            "refseq_ac": "XP_002661286",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate carrier",
                    "type": "recommended"
                },
                {
                    "name": "Solute carrier family 25 member 10",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial dicarboxylate carrier isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "slc25a10a",
                    "type": "recommended"
                },
                {
                    "name": "slc25a10a",
                    "type": "synonym"
                }
            ],
            "record_id": "F1QDE0-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9QZD8-1",
            "uniprot_ac": "Q9QZD8",
            "uniprot_id": "DIC_MOUSE",
            "refseq_ac": "NP_038798",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate carrier",
                    "type": "recommended"
                },
                {
                    "name": "DIC",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 25 member 10",
                    "type": "synonym"
                },
                {
                    "name": "adenine nucleotide translocator), member 10",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate ion carrier",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial dicarboxylate carrier",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 25 (mitochondrial carrier",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 25 member 10",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Slc25a10",
                    "type": "recommended"
                },
                {
                    "name": "Dic",
                    "type": "synonym"
                },
                {
                    "name": "Slc25a10",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9QZD8-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9UBX3-1",
            "uniprot_ac": "Q9UBX3",
            "uniprot_id": "DIC_HUMAN",
            "refseq_ac": "NP_001257817",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate carrier",
                    "type": "recommended"
                },
                {
                    "name": "DIC",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 25 member 10",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate ion carrier",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate transporter), member 10",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial dicarboxylate carrier isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial dicarboxylate carrier",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 25 (mitochondrial carrier",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SLC25A10",
                    "type": "recommended"
                },
                {
                    "name": "DIC",
                    "type": "synonym"
                },
                {
                    "name": "MTDPS19",
                    "type": "synonym"
                },
                {
                    "name": "SLC25A10",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9UBX3-1",
            "evidence": [
                {
                    "id": "618972",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618972"
                },
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q06143-1",
            "uniprot_ac": "Q06143",
            "uniprot_id": "DIC1_YEAST",
            "refseq_ac": "NP_013452",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate transporter",
                    "type": "recommended"
                },
                {
                    "name": "DTP",
                    "type": "synonym"
                },
                {
                    "name": "Dic1p",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DIC1",
                    "type": "recommended"
                },
                {
                    "name": "DIC1",
                    "type": "synonym"
                }
            ],
            "record_id": "Q06143-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O89035-1",
            "uniprot_ac": "O89035",
            "uniprot_id": "DIC_RAT",
            "refseq_ac": "NP_596909",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate carrier",
                    "type": "recommended"
                },
                {
                    "name": "DIC",
                    "type": "synonym"
                },
                {
                    "name": "Solute carrier family 25 member 10",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate transporter), member 10",
                    "type": "synonym"
                },
                {
                    "name": "mitochondrial dicarboxylate carrier",
                    "type": "synonym"
                },
                {
                    "name": "solute carrier family 25 (mitochondrial carrier",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Slc25a10",
                    "type": "recommended"
                },
                {
                    "name": "Dic",
                    "type": "synonym"
                },
                {
                    "name": "Slc25a10",
                    "type": "synonym"
                }
            ],
            "record_id": "O89035-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Y166-1",
            "uniprot_ac": "Q9Y166",
            "uniprot_id": "Q9Y166_DROME",
            "refseq_ac": "NP_001287313",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG8790-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dic1-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 1, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 1, isoform B",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 1, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate carrier 1, isoform C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dic1",
                    "type": "recommended"
                },
                {
                    "name": "BcDNA:GH02431",
                    "type": "synonym"
                },
                {
                    "name": "CG8790",
                    "type": "synonym"
                },
                {
                    "name": "Dic1",
                    "type": "synonym"
                },
                {
                    "name": "DmDic1p",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG8790",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG8790",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Y166-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VVS1-1",
            "uniprot_ac": "Q9VVS1",
            "uniprot_id": "Q9VVS1_DROME",
            "refseq_ac": "NP_001262021",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG18363-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dic4-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 4, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 4, isoform C",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate carrier 4, isoform C",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dic4",
                    "type": "recommended"
                },
                {
                    "name": "CG18363",
                    "type": "synonym"
                },
                {
                    "name": "Dic4",
                    "type": "synonym"
                },
                {
                    "name": "DmDic4p",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG18363",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG18363",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VVS1-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VDM3-1",
            "uniprot_ac": "Q9VDM3",
            "uniprot_id": "Q9VDM3_DROME",
            "refseq_ac": "NP_732513",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG4323-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dic2-PC",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 2",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate carrier 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dic2",
                    "type": "recommended"
                },
                {
                    "name": "CG4323",
                    "type": "synonym"
                },
                {
                    "name": "Dic2",
                    "type": "synonym"
                },
                {
                    "name": "DmDic2p",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG4323",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG4323",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VDM3-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A6M3Q724-1",
            "uniprot_ac": "A0A6M3Q724",
            "uniprot_id": "A0A6M3Q724_DROME",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mitochondrial dicarboxylate carrier",
                    "type": "recommended"
                }
            ],
            "gene_names": [
                {
                    "name": "Dmel\\CG6893",
                    "type": "recommended"
                },
                {
                    "name": "CG6893",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG6893",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A6M3Q724-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A1Z787-1",
            "uniprot_ac": "A1Z787",
            "uniprot_id": "A1Z787_DROME",
            "refseq_ac": "NP_610344",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "CG11196-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dic3-PA",
                    "type": "synonym"
                },
                {
                    "name": "Dicarboxylate carrier 3, isoform A",
                    "type": "synonym"
                },
                {
                    "name": "dicarboxylate carrier 3, isoform A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Dic3",
                    "type": "recommended"
                },
                {
                    "name": "CG11196",
                    "type": "synonym"
                },
                {
                    "name": "Dic3p",
                    "type": "synonym"
                },
                {
                    "name": "Dic3",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG11196",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG11196",
                    "type": "synonym"
                }
            ],
            "record_id": "A1Z787-1",
            "evidence": [
                {
                    "id": "0070450",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070450"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070450"
}