{
    "disease_id": "DOID:0070356",
    "recommended_name": {
        "id": "DOID:0070356",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070356",
        "name": "visual impairment and progressive phthisis bulbi",
        "description": "An eye disease that is characterized by poor vision at birth, with development of bilateral phthisis by adulthood and that has_material_basis_in homozygous mutation in the MARK3 gene on chromosome 14q3."
    },
    "synonyms": [
        {
            "id": "MONDO:0032655",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0032655",
            "name": "visual impairment and progressive phthisis bulbi",
            "description": ""
        },
        {
            "id": "MONDO:0032655",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0032655",
            "name": "VIPB",
            "description": ""
        },
        {
            "id": "MIM:618283",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/618283",
            "name": "Visual impairment and progressive phthisis bulbi",
            "description": "Visual impairment and progressive phthisis bulbi"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070356"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070356",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070356",
            "categories": []
        },
        {
            "id": "MONDO:0032655",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0032655",
            "categories": []
        },
        {
            "id": "MIM:618283",
            "database": "MIM",
            "url": "https://www.omim.org/entry/618283",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M9PXN3-1",
            "uniprot_ac": "A0A8M9PXN3",
            "uniprot_id": "A0A8M9PXN3_DANRE",
            "refseq_ac": "XP_021336197",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3a isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark3a",
                    "type": "recommended"
                },
                {
                    "name": "fi39g08",
                    "type": "synonym"
                },
                {
                    "name": "mark3a",
                    "type": "synonym"
                },
                {
                    "name": "mark3",
                    "type": "synonym"
                },
                {
                    "name": "wu:fi39g08",
                    "type": "synonym"
                },
                {
                    "name": "zgc:152848",
                    "type": "synonym"
                },
                {
                    "name": "zgc:55693",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M9PXN3-1",
            "evidence": [
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M3AL25-1",
            "uniprot_ac": "A0A8M3AL25",
            "uniprot_id": "A0A8M3AL25_DANRE",
            "refseq_ac": "XP_009293196",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark3b",
                    "type": "recommended"
                },
                {
                    "name": "mark3b",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-50f7.6",
                    "type": "synonym"
                },
                {
                    "name": "zgc:153725",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M3AL25-1",
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                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M2B3S3-1",
            "uniprot_ac": "A0A8M2B3S3",
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            "refseq_ac": "XP_005157655",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
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                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 4 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark4b",
                    "type": "recommended"
                },
                {
                    "name": "mark4b",
                    "type": "synonym"
                }
            ],
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                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M3BAY8-1",
            "uniprot_ac": "A0A8M3BAY8",
            "uniprot_id": "A0A8M3BAY8_DANRE",
            "refseq_ac": "XP_009301419",
            "glycoprotein": "yes",
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                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase MARK2 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark2b",
                    "type": "recommended"
                },
                {
                    "name": "mark2b",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M3BAY8-1",
            "evidence": [
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M2BCS1-1",
            "uniprot_ac": "A0A8M2BCS1",
            "uniprot_id": "A0A8M2BCS1_DANRE",
            "refseq_ac": "XP_021332218",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 4 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark4a",
                    "type": "recommended"
                },
                {
                    "name": "mark4a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M2BCS1-1",
            "evidence": [
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M3B4V1-1",
            "uniprot_ac": "A0A8M3B4V1",
            "uniprot_id": "A0A8M3B4V1_DANRE",
            "refseq_ac": "XP_009293774",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
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                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
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                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase MARK2 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mark2a",
                    "type": "recommended"
                },
                {
                    "name": "mark2a",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q03141-1",
            "uniprot_ac": "Q03141",
            "uniprot_id": "MARK3_MOUSE",
            "refseq_ac": "NP_067491",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3",
                    "type": "recommended"
                },
                {
                    "name": "2.7.11.1",
                    "type": "synonym"
                },
                {
                    "name": "ELKL motif kinase 2",
                    "type": "synonym"
                },
                {
                    "name": "EMK-2",
                    "type": "synonym"
                },
                {
                    "name": "EMK2/MARK3 serine-threonine protein kinase",
                    "type": "synonym"
                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 3 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "MPK-10",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Mark3",
                    "type": "recommended"
                },
                {
                    "name": "1600015G02Rik",
                    "type": "synonym"
                },
                {
                    "name": "A430080F22Rik",
                    "type": "synonym"
                },
                {
                    "name": "C-TAK1",
                    "type": "synonym"
                },
                {
                    "name": "ETK-1",
                    "type": "synonym"
                },
                {
                    "name": "ETK1",
                    "type": "synonym"
                },
                {
                    "name": "Emk2",
                    "type": "synonym"
                },
                {
                    "name": "MPK10",
                    "type": "synonym"
                },
                {
                    "name": "Mark3",
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                },
                {
                    "name": "Mpk10",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8CIP4-1",
            "uniprot_ac": "Q8CIP4",
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            "refseq_ac": "NP_758483",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
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                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
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                    "name": "MAP/microtubule affinity-regulating kinase 4",
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                },
                {
                    "name": "2.7.11.1",
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                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 4 isoform 1",
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                {
                    "name": "MARK4 serine/threonine protein kinase",
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                }
            ],
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                {
                    "name": "Mark4",
                    "type": "recommended"
                },
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                    "name": "2410090P21Rik",
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                {
                    "name": "Kiaa1860",
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                },
                {
                    "name": "Mark4",
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                {
                    "name": "Markl1",
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                }
            ],
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                    "id": "0070356",
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                }
            ]
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        {
            "uniprot_canonical_ac": "Q8VHJ5-1",
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                    "name": "Mus musculus",
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                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
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                    "name": "Serine/threonine-protein kinase MARK1",
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                },
                {
                    "name": "2.7.11.26",
                    "type": "synonym"
                },
                {
                    "name": "ELKL motif serine-threonine protein kinase 3",
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                },
                {
                    "name": "ELKL motif serine/threonine-protein kinase 3",
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                {
                    "name": "MAP/microtubule affinity-regulating kinase 1",
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                },
                {
                    "name": "PAR1 homolog c",
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                },
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                    "name": "Par-1c",
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                {
                    "name": "mPar-1c",
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                },
                {
                    "name": "serine/threonine-protein kinase MARK1 isoform 2",
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                },
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                    "name": "serine/threonine-protein kinase MARK1",
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                }
            ],
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                },
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                    "name": "Emk3",
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                    "name": "Kiaa1477",
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                },
                {
                    "name": "Par-1c",
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                },
                {
                    "name": "mKIAA1477",
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                {
                    "name": "mPar-1c",
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            ],
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                    "id": "0070356",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q05512-1",
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                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
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                }
            ],
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                {
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                {
                    "name": "ELKL motif kinase 1",
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                    "name": "EMK-1",
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                },
                {
                    "name": "MAP/microtubule affinity-regulating kinase 2",
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                },
                {
                    "name": "PAR1 homolog b",
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                },
                {
                    "name": "PAR1 homolog",
                    "type": "synonym"
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                {
                    "name": "Par-1b",
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                },
                {
                    "name": "mPar-1b",
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                },
                {
                    "name": "serine/threonine-protein kinase MARK2 isoform 2",
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                },
                {
                    "name": "serine/threonine-protein kinase MARK2",
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                }
            ],
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                    "name": "Mark2",
                    "type": "recommended"
                },
                {
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                },
                {
                    "name": "Emk",
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                    "name": "Mark2",
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                    "name": "Par-1b",
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                {
                    "name": "Par-1",
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                }
            ],
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                {
                    "id": "0070356",
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                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
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            "uniprot_canonical_ac": "P27448-5",
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                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
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                    "reference_species": "Homo sapiens [9606]"
                }
            ],
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                },
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                    "name": "2.7.11.1",
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                },
                {
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                },
                {
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                    "name": "ELKL motif kinase 2",
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                {
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                },
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                    "name": "MAP/microtubule affinity-regulating kinase 3",
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                },
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                {
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                },
                {
                    "name": "Ser/Thr protein kinase PAR-1",
                    "type": "synonym"
                },
                {
                    "name": "Serine/threonine-protein kinase p78",
                    "type": "synonym"
                },
                {
                    "name": "cTAK1",
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                },
                {
                    "name": "cdc25C-associated protein kinase 1",
                    "type": "synonym"
                },
                {
                    "name": "protein kinase STK10",
                    "type": "synonym"
                },
                {
                    "name": "ser/Thr protein kinase PAR-1",
                    "type": "synonym"
                },
                {
                    "name": "serine/threonine-protein kinase p78",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MARK3",
                    "type": "recommended"
                },
                {
                    "name": "CTAK1",
                    "type": "synonym"
                },
                {
                    "name": "EMK2",
                    "type": "synonym"
                },
                {
                    "name": "KP78",
                    "type": "synonym"
                },
                {
                    "name": "MARK3",
                    "type": "synonym"
                },
                {
                    "name": "PAR1A",
                    "type": "synonym"
                },
                {
                    "name": "Par-1a",
                    "type": "synonym"
                },
                {
                    "name": "VIPB",
                    "type": "synonym"
                }
            ],
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            "evidence": [
                {
                    "id": "618283",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/618283"
                },
                {
                    "id": "0070356",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070356"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8VHF0-1",
            "uniprot_ac": "Q8VHF0",
            "uniprot_id": "MARK3_RAT",
            "refseq_ac": "NP_570105",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
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}