{
    "disease_id": "DOID:0070187",
    "recommended_name": {
        "id": "DOID:0070187",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0070187",
        "name": "Y-linked spermatogenic failure 2",
        "description": "A spermatogenic failure that is characterized by nonobstroctive azoospermia or oligozoospermia that has_material_basis_in interstitial deletions on the Yq11.221 chromosomal region."
    },
    "synonyms": [
        {
            "id": "DOID:0070187",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070187",
            "name": "SPGFY2",
            "description": ""
        },
        {
            "id": "DOID:0070187",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070187",
            "name": "nonobstructive Y-linked spermatogenic failure",
            "description": ""
        },
        {
            "id": "MONDO:0010767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "name": "spermatogenic failure, Y-linked, 2",
            "description": ""
        },
        {
            "id": "MONDO:0010767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "name": "spermatogenic failure, Y-linked, 2",
            "description": ""
        },
        {
            "id": "MONDO:0010767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "name": "spermatogenic failure, Y-linked, 2, Y-linked",
            "description": ""
        },
        {
            "id": "MONDO:0010767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "name": "spermatogenic failure, Y-linked, type 2",
            "description": ""
        },
        {
            "id": "MONDO:0010767",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "name": "SPGFY2",
            "description": ""
        },
        {
            "id": "MIM:415000",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/415000",
            "name": "Spermatogenic failure Y-linked 2",
            "description": "Spermatogenic failure Y-linked 2"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0070187"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0070187",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0070187",
            "categories": []
        },
        {
            "id": "MONDO:0010767",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010767",
            "categories": []
        },
        {
            "id": "MIM:415000",
            "database": "MIM",
            "url": "https://www.omim.org/entry/415000",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0A8M3AW48-1",
            "uniprot_ac": "A0A8M3AW48",
            "uniprot_id": "A0A8M3AW48_DANRE",
            "refseq_ac": "XP_009303032",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "ubiquitinyl hydrolase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.4.19.12",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin carboxyl-terminal hydrolase 9X isoform X4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "usp9",
                    "type": "recommended"
                },
                {
                    "name": "usp9",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M3AW48-1",
            "evidence": [
                {
                    "id": "0070187",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070187"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "F8VPU6-1",
            "uniprot_ac": "F8VPU6",
            "uniprot_id": "USP9Y_MOUSE",
            "refseq_ac": "NP_683745",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ubiquitin carboxyl-terminal hydrolase 9Y",
                    "type": "recommended"
                },
                {
                    "name": "3.4.19.12",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin carboxyl-terminal hydrolase 9Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin specific protease 9, Y chromosome",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Usp9y",
                    "type": "recommended"
                },
                {
                    "name": "Dffry",
                    "type": "synonym"
                },
                {
                    "name": "Fafl2",
                    "type": "synonym"
                },
                {
                    "name": "Usp9y",
                    "type": "synonym"
                }
            ],
            "record_id": "F8VPU6-1",
            "evidence": [
                {
                    "id": "0070187",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070187"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q86SG3-1",
            "uniprot_ac": "Q86SG3",
            "uniprot_id": "DAZ4_HUMAN",
            "refseq_ac": "NP_001005375",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Deleted in azoospermia protein 4",
                    "type": "recommended"
                },
                {
                    "name": "deleted in azoospermia protein 4 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "deleted in azoospermia protein 4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DAZ4",
                    "type": "recommended"
                },
                {
                    "name": "DAZ4",
                    "type": "synonym"
                },
                {
                    "name": "pDP1680",
                    "type": "synonym"
                },
                {
                    "name": "pDP1681",
                    "type": "synonym"
                }
            ],
            "record_id": "Q86SG3-1",
            "evidence": [
                {
                    "id": "415000",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/415000"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NQZ3-1",
            "uniprot_ac": "Q9NQZ3",
            "uniprot_id": "DAZ1_HUMAN",
            "refseq_ac": "NP_004072",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Deleted in azoospermia protein 1",
                    "type": "recommended"
                },
                {
                    "name": "deleted in azoospermia protein 1 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "deleted in azoospermia protein 1",
                    "type": "synonym"
                },
                {
                    "name": "testicular tissue protein Li 49",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DAZ1",
                    "type": "recommended"
                },
                {
                    "name": "DAZ1",
                    "type": "synonym"
                },
                {
                    "name": "DAZ",
                    "type": "synonym"
                },
                {
                    "name": "SPGY",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9NQZ3-1",
            "evidence": [
                {
                    "id": "415000",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/415000"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q13117-1",
            "uniprot_ac": "Q13117",
            "uniprot_id": "DAZ2_HUMAN",
            "refseq_ac": "NP_001005785",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Deleted in azoospermia protein 2",
                    "type": "recommended"
                },
                {
                    "name": "deleted in azoospermia protein 2 isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "deleted in azoospermia protein 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DAZ2",
                    "type": "recommended"
                },
                {
                    "name": "DAZ2",
                    "type": "synonym"
                },
                {
                    "name": "pDP1678",
                    "type": "synonym"
                }
            ],
            "record_id": "Q13117-1",
            "evidence": [
                {
                    "id": "415000",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/415000"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9NR90-1",
            "uniprot_ac": "Q9NR90",
            "uniprot_id": "DAZ3_HUMAN",
            "refseq_ac": "NP_065097",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Deleted in azoospermia protein 3",
                    "type": "recommended"
                },
                {
                    "name": "deleted in azoospermia protein 3",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "DAZ3",
                    "type": "recommended"
                },
                {
                    "name": "DAZ3",
                    "type": "synonym"
                },
                {
                    "name": "pDP1679",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9NR90-1",
            "evidence": [
                {
                    "id": "415000",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/415000"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "O00507-1",
            "uniprot_ac": "O00507",
            "uniprot_id": "USP9Y_HUMAN",
            "refseq_ac": "NP_004645",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ubiquitin carboxyl-terminal hydrolase 9Y",
                    "type": "recommended"
                },
                {
                    "name": "3.4.19.12",
                    "type": "synonym"
                },
                {
                    "name": "Deubiquitinating enzyme FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "Fat facets protein-related, Y-linked",
                    "type": "synonym"
                },
                {
                    "name": "Ubiquitin thioesterase FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "Ubiquitin-specific protease 9, Y chromosome",
                    "type": "synonym"
                },
                {
                    "name": "Ubiquitin-specific-processing protease FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "azoospermia factor A",
                    "type": "synonym"
                },
                {
                    "name": "deubiquitinating enzyme FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "fat facets protein-related, Y-linked",
                    "type": "synonym"
                },
                {
                    "name": "probable ubiquitin carboxyl-terminal hydrolase FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin carboxyl-terminal hydrolase 9Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin thioesterase FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin thiolesterase FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin-specific processing protease FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin-specific protease 9, Y chromosome",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "USP9Y",
                    "type": "recommended"
                },
                {
                    "name": "DFFRY",
                    "type": "synonym"
                },
                {
                    "name": "FAF-Y",
                    "type": "synonym"
                },
                {
                    "name": "SPGFY2",
                    "type": "synonym"
                },
                {
                    "name": "USP9Y",
                    "type": "synonym"
                }
            ],
            "record_id": "O00507-1",
            "evidence": [
                {
                    "id": "415000",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/415000"
                },
                {
                    "id": "0070187",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070187"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A1B0GWT2-1",
            "uniprot_ac": "A0A1B0GWT2",
            "uniprot_id": "A0A1B0GWT2_RAT",
            "refseq_ac": "XP_038956586",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "ubiquitinyl hydrolase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.4.19.12",
                    "type": "synonym"
                },
                {
                    "name": "ubiquitin specific peptidase 9, Y-linked isoform X2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Usp9y",
                    "type": "recommended"
                },
                {
                    "name": "Usp9y",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A1B0GWT2-1",
            "evidence": [
                {
                    "id": "0070187",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070187"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P55824-1",
            "uniprot_ac": "P55824",
            "uniprot_id": "FAF_DROME",
            "refseq_ac": "NP_524612",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Ubiquitinyl hydrolase FAF",
                    "type": "recommended"
                },
                {
                    "name": "3.4.19.12",
                    "type": "synonym"
                },
                {
                    "name": "CG1945-PA",
                    "type": "synonym"
                },
                {
                    "name": "Deubiquitinating enzyme FAF",
                    "type": "synonym"
                },
                {
                    "name": "Fat facets",
                    "type": "synonym"
                },
                {
                    "name": "Fat-Facets",
                    "type": "synonym"
                },
                {
                    "name": "Protein fat facets",
                    "type": "synonym"
                },
                {
                    "name": "Ubiquitin thioesterase FAF",
                    "type": "synonym"
                },
                {
                    "name": "Ubiquitin-specific-processing protease FAF",
                    "type": "synonym"
                },
                {
                    "name": "faf-PA",
                    "type": "synonym"
                },
                {
                    "name": "fat facets, isoform A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "faf",
                    "type": "recommended"
                },
                {
                    "name": "BcDNA.LD22582",
                    "type": "synonym"
                },
                {
                    "name": "BcDNA:LD22582",
                    "type": "synonym"
                },
                {
                    "name": "CG1945",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG1945",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG1945",
                    "type": "synonym"
                },
                {
                    "name": "FAF",
                    "type": "synonym"
                },
                {
                    "name": "Faf",
                    "type": "synonym"
                },
                {
                    "name": "Fat",
                    "type": "synonym"
                },
                {
                    "name": "P55824",
                    "type": "synonym"
                },
                {
                    "name": "USPX",
                    "type": "synonym"
                },
                {
                    "name": "faf",
                    "type": "synonym"
                }
            ],
            "record_id": "P55824-1",
            "evidence": [
                {
                    "id": "0070187",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070187"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0070187"
}