{
    "disease_id": "DOID:0061237",
    "recommended_name": {
        "id": "DOID:0061237",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0061237",
        "name": "aggressive periodontitis 1",
        "description": "A periodontitis that has_material_basis_in homozygous mutation in the CTSC gene on chromosome 11q14."
    },
    "synonyms": [
        {
            "id": "DOID:0061237",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061237",
            "name": "juvenile periodontitis",
            "description": ""
        },
        {
            "id": "DOID:0061237",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061237",
            "name": "prepubertal periodontitis",
            "description": ""
        },
        {
            "id": "MONDO:0008226",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008226",
            "name": "periodontitis, aggressive 1",
            "description": "A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people."
        },
        {
            "id": "MONDO:0008226",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008226",
            "name": "periodontitis 1, juvenile",
            "description": ""
        },
        {
            "id": "MONDO:0008226",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008226",
            "name": "periodontitis, aggressive, type 1",
            "description": ""
        },
        {
            "id": "MIM:170650",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/170650",
            "name": "Periodontititis, aggressive, 1",
            "description": "Periodontititis, aggressive, 1"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0061237"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0061237",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061237",
            "categories": []
        },
        {
            "id": "MONDO:0008226",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0008226",
            "categories": []
        },
        {
            "id": "MIM:170650",
            "database": "MIM",
            "url": "https://www.omim.org/entry/170650",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P53634-1",
            "uniprot_ac": "P53634",
            "uniprot_id": "CATC_HUMAN",
            "refseq_ac": "NP_001107645",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Dipeptidyl peptidase 1",
                    "type": "recommended"
                },
                {
                    "name": "3.4.14.1",
                    "type": "synonym"
                },
                {
                    "name": "Cathepsin C",
                    "type": "synonym"
                },
                {
                    "name": "Cathepsin J",
                    "type": "synonym"
                },
                {
                    "name": "DPP-I",
                    "type": "synonym"
                },
                {
                    "name": "DPPI",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl peptidase I exclusion domain chain",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl peptidase I heavy chain",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl peptidase I light chain",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl peptidase I",
                    "type": "synonym"
                },
                {
                    "name": "Dipeptidyl transferase",
                    "type": "synonym"
                },
                {
                    "name": "cathepsin J",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl peptidase 1 isoform c precursor",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl peptidase 1",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl transferase",
                    "type": "synonym"
                },
                {
                    "name": "dipeptidyl-peptidase I",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "CTSC",
                    "type": "recommended"
                },
                {
                    "name": "CPPI",
                    "type": "synonym"
                },
                {
                    "name": "CTSC",
                    "type": "synonym"
                },
                {
                    "name": "DPP-I",
                    "type": "synonym"
                },
                {
                    "name": "DPP1",
                    "type": "synonym"
                },
                {
                    "name": "DPPI",
                    "type": "synonym"
                },
                {
                    "name": "HMS",
                    "type": "synonym"
                },
                {
                    "name": "JPD",
                    "type": "synonym"
                },
                {
                    "name": "JP",
                    "type": "synonym"
                },
                {
                    "name": "PALS",
                    "type": "synonym"
                },
                {
                    "name": "PDON1",
                    "type": "synonym"
                },
                {
                    "name": "PLS",
                    "type": "synonym"
                }
            ],
            "record_id": "P53634-1",
            "evidence": [
                {
                    "id": "170650",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/170650"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0061237"
}