{
    "disease_id": "DOID:0061220",
    "recommended_name": {
        "id": "DOID:0061220",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0061220",
        "name": "pheochromocytoma/paraganglioma syndrome 5",
        "description": "A paraganglioma characterized by the development of neuroendocrine tumors, usually in adulthood that has material_basis_in heterozygous mutation in the SDHA gene on chromosome 5p15."
    },
    "synonyms": [
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "pheochromocytoma/paraganglioma syndrome 5",
            "description": "Any paraganglioma in which the cause of the disease is a mutation in the SDHA gene."
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "SDHA paraganglioma",
            "description": ""
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "paraganglioma caused by mutation in SDHA",
            "description": ""
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "paragangliomas 5",
            "description": ""
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "paragangliomas type 5",
            "description": ""
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "pheochromocytoma/paraganglioma syndrome 5",
            "description": ""
        },
        {
            "id": "MONDO:0013602",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "name": "PGL5",
            "description": ""
        },
        {
            "id": "MIM:614165",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/614165",
            "name": "Pheochromocytoma/paraganglioma syndrome 5",
            "description": "Pheochromocytoma/paraganglioma syndrome 5"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0061220"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0061220",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061220",
            "categories": []
        },
        {
            "id": "MONDO:0013602",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0013602",
            "categories": []
        },
        {
            "id": "MIM:614165",
            "database": "MIM",
            "url": "https://www.omim.org/entry/614165",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q7ZVF3-1",
            "uniprot_ac": "Q7ZVF3",
            "uniprot_id": "SDHA_DANRE",
            "refseq_ac": "NP_957204",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.1.5.-",
                    "type": "synonym"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "Fp",
                    "type": "synonym"
                },
                {
                    "name": "Malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "fp",
                    "type": "synonym"
                },
                {
                    "name": "malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "sdha",
                    "type": "recommended"
                },
                {
                    "name": "im:7141001",
                    "type": "synonym"
                },
                {
                    "name": "sdha",
                    "type": "synonym"
                },
                {
                    "name": "si:dkeyp-84f11.2",
                    "type": "synonym"
                },
                {
                    "name": "zgc:56051",
                    "type": "synonym"
                }
            ],
            "record_id": "Q7ZVF3-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q8K2B3-1",
            "uniprot_ac": "Q8K2B3",
            "uniprot_id": "SDHA_MOUSE",
            "refseq_ac": "NP_075770",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.1.5.-",
                    "type": "synonym"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "E3-10 Sdha",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "Fp",
                    "type": "synonym"
                },
                {
                    "name": "Malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sdha",
                    "type": "recommended"
                },
                {
                    "name": "1500032O14Rik",
                    "type": "synonym"
                },
                {
                    "name": "2310034D06Rik",
                    "type": "synonym"
                },
                {
                    "name": "4921513A11",
                    "type": "synonym"
                },
                {
                    "name": "FP",
                    "type": "synonym"
                },
                {
                    "name": "SDH2",
                    "type": "synonym"
                },
                {
                    "name": "SDHF",
                    "type": "synonym"
                },
                {
                    "name": "Sdha",
                    "type": "synonym"
                }
            ],
            "record_id": "Q8K2B3-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P31040-1",
            "uniprot_ac": "P31040",
            "uniprot_id": "SDHA_HUMAN",
            "refseq_ac": "NP_001281261",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.1.5.-",
                    "type": "synonym"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "Fp",
                    "type": "synonym"
                },
                {
                    "name": "Malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase complex, subunit A, flavoprotein (Fp)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SDHA",
                    "type": "recommended"
                },
                {
                    "name": "CMD1GG",
                    "type": "synonym"
                },
                {
                    "name": "FP",
                    "type": "synonym"
                },
                {
                    "name": "MC2DN1",
                    "type": "synonym"
                },
                {
                    "name": "NDAXOA",
                    "type": "synonym"
                },
                {
                    "name": "PGL5",
                    "type": "synonym"
                },
                {
                    "name": "PPGL5",
                    "type": "synonym"
                },
                {
                    "name": "SDH1",
                    "type": "synonym"
                },
                {
                    "name": "SDH2",
                    "type": "synonym"
                },
                {
                    "name": "SDHA",
                    "type": "synonym"
                },
                {
                    "name": "SDHF",
                    "type": "synonym"
                }
            ],
            "record_id": "P31040-1",
            "evidence": [
                {
                    "id": "614165",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/614165"
                },
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P47052-1",
            "uniprot_ac": "P47052",
            "uniprot_id": "SDHX_YEAST",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "FP",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "SDH1b",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "J1194",
                    "type": "synonym"
                }
            ],
            "record_id": "P47052-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q00711-1",
            "uniprot_ac": "Q00711",
            "uniprot_id": "SDHA_YEAST",
            "refseq_ac": "NP_012774",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "FP",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase flavoprotein subunit SDH1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SDH1",
                    "type": "recommended"
                },
                {
                    "name": "SDH1",
                    "type": "synonym"
                },
                {
                    "name": "SDHA",
                    "type": "synonym"
                },
                {
                    "name": "YKL602",
                    "type": "synonym"
                }
            ],
            "record_id": "Q00711-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q920L2-1",
            "uniprot_ac": "Q920L2",
            "uniprot_id": "SDHA_RAT",
            "refseq_ac": "NP_569112",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.1.5.-",
                    "type": "synonym"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "Fp",
                    "type": "synonym"
                },
                {
                    "name": "Malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "fp",
                    "type": "synonym"
                },
                {
                    "name": "malate dehydrogenase [quinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase complex, subunit A, flavoprotein (Fp)",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Sdha",
                    "type": "recommended"
                },
                {
                    "name": "Sdha",
                    "type": "synonym"
                }
            ],
            "record_id": "Q920L2-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q94523-1",
            "uniprot_ac": "Q94523",
            "uniprot_id": "SDHA_DROME",
            "refseq_ac": "NP_477210",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",
                    "type": "recommended"
                },
                {
                    "name": "1.3.5.1",
                    "type": "synonym"
                },
                {
                    "name": "CG17246-PA",
                    "type": "synonym"
                },
                {
                    "name": "COMPLEX II: flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "FP",
                    "type": "synonym"
                },
                {
                    "name": "Flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "SUCCINYL COENZIME A SYNTHETASE FLAVOPROTEIN SUBUNIT",
                    "type": "synonym"
                },
                {
                    "name": "SdhA-PA",
                    "type": "synonym"
                },
                {
                    "name": "Succinyl coenzyme A synthetase flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase A",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase flavoprotein subunit",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase flavoprotein",
                    "type": "synonym"
                },
                {
                    "name": "succinate dehydrogenase, subunit A (flavoprotein), isoform A",
                    "type": "synonym"
                },
                {
                    "name": "succinyl CoA synthetase flavoprotein subunit of complex II",
                    "type": "synonym"
                },
                {
                    "name": "succinyl coenzyme A synthetase flavoprotein subunit",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "SdhA",
                    "type": "recommended"
                },
                {
                    "name": "2R1",
                    "type": "synonym"
                },
                {
                    "name": "CG17246",
                    "type": "synonym"
                },
                {
                    "name": "DHSA",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG17246",
                    "type": "synonym"
                },
                {
                    "name": "SDH",
                    "type": "synonym"
                },
                {
                    "name": "Scs-fp",
                    "type": "synonym"
                },
                {
                    "name": "Sdh A",
                    "type": "synonym"
                },
                {
                    "name": "SdhA",
                    "type": "synonym"
                },
                {
                    "name": "Sdha",
                    "type": "synonym"
                },
                {
                    "name": "Sdh",
                    "type": "synonym"
                },
                {
                    "name": "dSDHA",
                    "type": "synonym"
                },
                {
                    "name": "scs-fp",
                    "type": "synonym"
                },
                {
                    "name": "sdhA",
                    "type": "synonym"
                },
                {
                    "name": "sdh",
                    "type": "synonym"
                }
            ],
            "record_id": "Q94523-1",
            "evidence": [
                {
                    "id": "0061220",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061220"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0061220"
}