{
    "disease_id": "DOID:0061121",
    "recommended_name": {
        "id": "DOID:0061121",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0061121",
        "name": "autosomal dominant tubulointerstitial kidney disease 6",
        "description": "An autosomal dominant tubulointerstitial kidney disease characterized by the onset of slowly progressive chronic renal failure beginning in mid-to-late adulthood that has_material_basis_in heterozygous mutation in the APOA4 gene on chromosome 11q23."
    },
    "synonyms": [
        {
            "id": "MONDO:0976234",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0976234",
            "name": "tubulointerstitial kidney disease, autosomal dominant 6",
            "description": ""
        },
        {
            "id": "MIM:621106",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/621106",
            "name": "Tubulointerstitial kidney disease, autosomal dominant 6",
            "description": "Tubulointerstitial kidney disease, autosomal dominant 6"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0061121"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0061121",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0061121",
            "categories": []
        },
        {
            "id": "MONDO:0976234",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0976234",
            "categories": []
        },
        {
            "id": "MIM:621106",
            "database": "MIM",
            "url": "https://www.omim.org/entry/621106",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AC58HH61-1",
            "uniprot_ac": "A0AC58HH61",
            "uniprot_id": "A0AC58HH61_DANRE",
            "refseq_ac": "XP_073781327",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Apolipoprotein A-IV b, tandem duplicate 2 isoform X1",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV b, tandem duplicate 2 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "apoa4b.2",
                    "type": "recommended"
                },
                {
                    "name": "apoa4b.3",
                    "type": "recommended"
                },
                {
                    "name": "apoa4b.2",
                    "type": "synonym"
                },
                {
                    "name": "fc28d04",
                    "type": "synonym"
                },
                {
                    "name": "si:dkey-7f3.15",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc10a03",
                    "type": "synonym"
                },
                {
                    "name": "wu:fc28d04",
                    "type": "synonym"
                },
                {
                    "name": "zgc:194131",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AC58HH61-1",
            "evidence": [
                {
                    "id": "0061121",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061121"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "A0A8M1N5N8-1",
            "uniprot_ac": "A0A8M1N5N8",
            "uniprot_id": "A0A8M1N5N8_DANRE",
            "refseq_ac": "NP_001017909",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Apolipoprotein A-IV",
                    "type": "recommended"
                },
                {
                    "name": "Apolipoprotein A4",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV a precursor",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "apoa4a",
                    "type": "recommended"
                },
                {
                    "name": "apoa4a",
                    "type": "synonym"
                },
                {
                    "name": "zgc:112992",
                    "type": "synonym"
                }
            ],
            "record_id": "A0A8M1N5N8-1",
            "evidence": [
                {
                    "id": "0061121",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061121"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06728-1",
            "uniprot_ac": "P06728",
            "uniprot_id": "APOA4_MOUSE",
            "refseq_ac": "NP_031494",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Apolipoprotein A-IV",
                    "type": "recommended"
                },
                {
                    "name": "Apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "ApoA-IV",
                    "type": "synonym"
                },
                {
                    "name": "Apolipoprotein A4",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV precursor",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A4",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Apoa4",
                    "type": "recommended"
                },
                {
                    "name": "Apoa-4",
                    "type": "synonym"
                },
                {
                    "name": "Apoa4",
                    "type": "synonym"
                },
                {
                    "name": "apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "apoA-IV",
                    "type": "synonym"
                }
            ],
            "record_id": "P06728-1",
            "evidence": [
                {
                    "id": "0061121",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061121"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P06727-1",
            "uniprot_ac": "P06727",
            "uniprot_id": "APOA4_HUMAN",
            "refseq_ac": "NP_000473",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Apolipoprotein A-IV",
                    "type": "recommended"
                },
                {
                    "name": "Apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "ApoA-IV",
                    "type": "synonym"
                },
                {
                    "name": "Apolipoprotein A4",
                    "type": "synonym"
                },
                {
                    "name": "apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "apoA-IV",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV precursor",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "APOA4",
                    "type": "recommended"
                },
                {
                    "name": "ADTKD6",
                    "type": "synonym"
                },
                {
                    "name": "APOA4",
                    "type": "synonym"
                }
            ],
            "record_id": "P06727-1",
            "evidence": [
                {
                    "id": "621106",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/621106"
                },
                {
                    "id": "0061121",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061121"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P02651-1",
            "uniprot_ac": "P02651",
            "uniprot_id": "APOA4_RAT",
            "refseq_ac": "NP_036869",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Apolipoprotein A-IV",
                    "type": "recommended"
                },
                {
                    "name": "Apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "ApoA-IV",
                    "type": "synonym"
                },
                {
                    "name": "Apolipoprotein A4",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV precursor",
                    "type": "synonym"
                },
                {
                    "name": "apolipoprotein A-IV",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Apoa4",
                    "type": "recommended"
                },
                {
                    "name": "Apo-AIV",
                    "type": "synonym"
                },
                {
                    "name": "ApoA-IV",
                    "type": "synonym"
                },
                {
                    "name": "Apoa4",
                    "type": "synonym"
                },
                {
                    "name": "apoAIV",
                    "type": "synonym"
                }
            ],
            "record_id": "P02651-1",
            "evidence": [
                {
                    "id": "0061121",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0061121"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0061121"
}