{
    "disease_id": "DOID:0060693",
    "recommended_name": {
        "id": "DOID:0060693",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060693",
        "name": "Brunner Syndrome",
        "description": "An amino acid metabolic disorder characterized by recessive X-linked inheritance, impaired monoamine metabolism, impulsive aggressiveness and mild mental retardation that has_material_basis_in mutation in the MAOA gene on chromosome Xp11."
    },
    "synonyms": [
        {
            "id": "DOID:0060693",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060693",
            "name": "monoamine oxidase A deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "Brunner syndrome",
            "description": "Monoamine oxidase-A deficiency is a very rare recessive X-linked biogenic amine metabolism disorder characterized clinically by mild intellectual deficit, impulsive aggressiveness, and sometimes violent behavior and presenting from childhood."
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "Brunner syndrome",
            "description": ""
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "Brunner syndrome, X-linked recessive",
            "description": ""
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "antisocial behavior, X-linked recessive",
            "description": ""
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "monoamine oxidase A deficiency",
            "description": ""
        },
        {
            "id": "MONDO:0010379",
            "resource": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "name": "BRNRS",
            "description": ""
        },
        {
            "id": "MIM:300615",
            "resource": "MIM",
            "url": "https://www.omim.org/entry/300615",
            "name": "Brunner syndrome",
            "description": "Brunner syndrome"
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060693"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060693",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060693",
            "categories": []
        },
        {
            "id": "MONDO:0010379",
            "database": "MONDO",
            "url": "https://monarchinitiative.org/disease/MONDO:0010379",
            "categories": []
        },
        {
            "id": "MIM:300615",
            "database": "MIM",
            "url": "https://www.omim.org/entry/300615",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "Q6NSN2-1",
            "uniprot_ac": "Q6NSN2",
            "uniprot_id": "AOF_DANRE",
            "refseq_ac": "NP_997992",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Amine oxidase [flavin-containing]",
                    "type": "recommended"
                },
                {
                    "name": "1.4.3.21",
                    "type": "synonym"
                },
                {
                    "name": "1.4.3.4",
                    "type": "synonym"
                },
                {
                    "name": "MAO",
                    "type": "synonym"
                },
                {
                    "name": "Monoamine oxidase",
                    "type": "synonym"
                },
                {
                    "name": "Z-MAO",
                    "type": "synonym"
                },
                {
                    "name": "amine oxidase [flavin-containing]",
                    "type": "synonym"
                },
                {
                    "name": "amine oxidase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "mao",
                    "type": "recommended"
                },
                {
                    "name": "Z-MAO",
                    "type": "synonym"
                },
                {
                    "name": "maob",
                    "type": "synonym"
                },
                {
                    "name": "mao",
                    "type": "synonym"
                },
                {
                    "name": "moa",
                    "type": "synonym"
                },
                {
                    "name": "wu:fb68b05",
                    "type": "synonym"
                },
                {
                    "name": "wu:fo76d11",
                    "type": "synonym"
                },
                {
                    "name": "wu:fq38g06",
                    "type": "synonym"
                },
                {
                    "name": "zgc:85761",
                    "type": "synonym"
                }
            ],
            "record_id": "Q6NSN2-1",
            "evidence": [
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q64133-1",
            "uniprot_ac": "Q64133",
            "uniprot_id": "AOFA_MOUSE",
            "refseq_ac": "NP_776101",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Amine oxidase [flavin-containing] A",
                    "type": "recommended"
                },
                {
                    "name": "1.4.3.21",
                    "type": "synonym"
                },
                {
                    "name": "1.4.3.4",
                    "type": "synonym"
                },
                {
                    "name": "MAO-A",
                    "type": "synonym"
                },
                {
                    "name": "Monoamine oxidase type A",
                    "type": "synonym"
                },
                {
                    "name": "amine oxidase [flavin-containing] A",
                    "type": "synonym"
                },
                {
                    "name": "monoamine oxidase type A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Maoa",
                    "type": "recommended"
                },
                {
                    "name": "1110061B18Rik",
                    "type": "synonym"
                },
                {
                    "name": "Maoa",
                    "type": "synonym"
                }
            ],
            "record_id": "Q64133-1",
            "evidence": [
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P21397-1",
            "uniprot_ac": "P21397",
            "uniprot_id": "AOFA_HUMAN",
            "refseq_ac": "NP_000231",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Amine oxidase [flavin-containing] A",
                    "type": "recommended"
                },
                {
                    "name": "1.4.3.21",
                    "type": "synonym"
                },
                {
                    "name": "1.4.3.4",
                    "type": "synonym"
                },
                {
                    "name": "MAO-A",
                    "type": "synonym"
                },
                {
                    "name": "Monoamine oxidase type A",
                    "type": "synonym"
                },
                {
                    "name": "amine oxidase [flavin-containing] A isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "amine oxidase [flavin-containing] A",
                    "type": "synonym"
                },
                {
                    "name": "monoamine oxidase type A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MAOA",
                    "type": "recommended"
                },
                {
                    "name": "BRNRS",
                    "type": "synonym"
                },
                {
                    "name": "MAO-A",
                    "type": "synonym"
                },
                {
                    "name": "MAOA",
                    "type": "synonym"
                }
            ],
            "record_id": "P21397-1",
            "evidence": [
                {
                    "id": "300615",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/300615"
                },
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P50264-1",
            "uniprot_ac": "P50264",
            "uniprot_id": "FMS1_YEAST",
            "refseq_ac": "NP_013733",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Saccharomyces cerevisiae S288C",
                    "taxid": 559292,
                    "common_name": "Baker's yeast",
                    "glygen_name": "Yeast",
                    "reference_species": "Saccharomyces cerevisiae S288C [559292]"
                }
            ],
            "protein_names": [
                {
                    "name": "Polyamine oxidase FMS1",
                    "type": "recommended"
                },
                {
                    "name": "1.5.3.17",
                    "type": "synonym"
                },
                {
                    "name": "Fenpropimorph resistance multicopy suppressor 1",
                    "type": "synonym"
                },
                {
                    "name": "polyamine oxidase",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "FMS1",
                    "type": "recommended"
                },
                {
                    "name": "FMS1",
                    "type": "synonym"
                },
                {
                    "name": "YM9711.09",
                    "type": "synonym"
                }
            ],
            "record_id": "P50264-1",
            "evidence": [
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "P21396-1",
            "uniprot_ac": "P21396",
            "uniprot_id": "AOFA_RAT",
            "refseq_ac": "",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Amine oxidase [flavin-containing] A",
                    "type": "recommended"
                },
                {
                    "name": "1.4.3.21",
                    "type": "synonym"
                },
                {
                    "name": "1.4.3.4",
                    "type": "synonym"
                },
                {
                    "name": "MAO-A",
                    "type": "synonym"
                },
                {
                    "name": "Monoamine oxidase type A",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Maoa",
                    "type": "recommended"
                }
            ],
            "record_id": "P21396-1",
            "evidence": [
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9VCA1-1",
            "uniprot_ac": "Q9VCA1",
            "uniprot_id": "Q9VCA1_DROME",
            "refseq_ac": "NP_651239",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Drosophila melanogaster",
                    "taxid": 7227,
                    "common_name": "Fruit fly",
                    "glygen_name": "Fruit fly",
                    "reference_species": "Drosophila melanogaster [7227]"
                }
            ],
            "protein_names": [
                {
                    "name": "monoamine oxidase",
                    "type": "recommended"
                },
                {
                    "name": "1.4.3.4",
                    "type": "synonym"
                },
                {
                    "name": "CG13611-PA",
                    "type": "synonym"
                },
                {
                    "name": "sheepish",
                    "type": "synonym"
                },
                {
                    "name": "shps-PA",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "shps",
                    "type": "recommended"
                },
                {
                    "name": "CG13611",
                    "type": "synonym"
                },
                {
                    "name": "Dmel\\CG13611",
                    "type": "synonym"
                },
                {
                    "name": "Dmel_CG13611",
                    "type": "synonym"
                },
                {
                    "name": "shps",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9VCA1-1",
            "evidence": [
                {
                    "id": "0060693",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060693"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060693"
}