{
    "disease_id": "DOID:0060548",
    "recommended_name": {
        "id": "DOID:0060548",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060548",
        "name": "luminal breast carcinoma A",
        "description": "A breast carcinoma that is characterized by high expression of genes characteristic of luminal epithelial cells, including estrogen receptor (ER), estrogen regulated protein LIV-1, and the transcription factors hepatocyte nuclear factor 3, HNF3A, XBP1, and GATA 3."
    },
    "synonyms": [
        {
            "id": "DOID:0060548",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060548",
            "name": "Luminal A Breast Carcinoma",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060548"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060548",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060548",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "P15941-1",
            "uniprot_ac": "P15941",
            "uniprot_id": "MUC1_HUMAN",
            "refseq_ac": "NP_001191215",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Mucin-1",
                    "type": "recommended"
                },
                {
                    "name": "Breast carcinoma-associated antigen DF3",
                    "type": "synonym"
                },
                {
                    "name": "CA 15-3",
                    "type": "synonym"
                },
                {
                    "name": "Cancer antigen 15-3",
                    "type": "synonym"
                },
                {
                    "name": "Carcinoma-associated mucin",
                    "type": "synonym"
                },
                {
                    "name": "EMA",
                    "type": "synonym"
                },
                {
                    "name": "Episialin",
                    "type": "synonym"
                },
                {
                    "name": "H23 antigen",
                    "type": "synonym"
                },
                {
                    "name": "H23AG",
                    "type": "synonym"
                },
                {
                    "name": "KL-6",
                    "type": "synonym"
                },
                {
                    "name": "Krebs von den Lungen-6",
                    "type": "synonym"
                },
                {
                    "name": "MUC-1",
                    "type": "synonym"
                },
                {
                    "name": "MUC1-CT",
                    "type": "synonym"
                },
                {
                    "name": "PEMT",
                    "type": "synonym"
                },
                {
                    "name": "PEM",
                    "type": "synonym"
                },
                {
                    "name": "PUM",
                    "type": "synonym"
                },
                {
                    "name": "Peanut-reactive urinary mucin",
                    "type": "synonym"
                },
                {
                    "name": "Polymorphic epithelial mucin",
                    "type": "synonym"
                },
                {
                    "name": "Tumor-associated epithelial membrane antigen",
                    "type": "synonym"
                },
                {
                    "name": "Tumor-associated mucin",
                    "type": "synonym"
                },
                {
                    "name": "breast carcinoma-associated antigen DF3",
                    "type": "synonym"
                },
                {
                    "name": "cancer antigen 15-3",
                    "type": "synonym"
                },
                {
                    "name": "carcinoma-associated mucin",
                    "type": "synonym"
                },
                {
                    "name": "episialin",
                    "type": "synonym"
                },
                {
                    "name": "krebs von den Lungen-6",
                    "type": "synonym"
                },
                {
                    "name": "mucin 1, transmembrane",
                    "type": "synonym"
                },
                {
                    "name": "mucin-1 isoform 10 precursor",
                    "type": "synonym"
                },
                {
                    "name": "peanut-reactive urinary mucin",
                    "type": "synonym"
                },
                {
                    "name": "polymorphic epithelial mucin",
                    "type": "synonym"
                },
                {
                    "name": "tumor associated epithelial mucin",
                    "type": "synonym"
                },
                {
                    "name": "tumor-associated epithelial membrane antigen",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "MUC1",
                    "type": "recommended"
                },
                {
                    "name": "ADMCKD1",
                    "type": "synonym"
                },
                {
                    "name": "ADMCKD",
                    "type": "synonym"
                },
                {
                    "name": "ADTKD2",
                    "type": "synonym"
                },
                {
                    "name": "CA 15-3",
                    "type": "synonym"
                },
                {
                    "name": "CD227",
                    "type": "synonym"
                },
                {
                    "name": "Ca15-3",
                    "type": "synonym"
                },
                {
                    "name": "EMA",
                    "type": "synonym"
                },
                {
                    "name": "H23AG",
                    "type": "synonym"
                },
                {
                    "name": "KL-6",
                    "type": "synonym"
                },
                {
                    "name": "MAM6",
                    "type": "synonym"
                },
                {
                    "name": "MCD",
                    "type": "synonym"
                },
                {
                    "name": "MCKD1",
                    "type": "synonym"
                },
                {
                    "name": "MCKD",
                    "type": "synonym"
                },
                {
                    "name": "MUC-1/SEC",
                    "type": "synonym"
                },
                {
                    "name": "MUC-1/X",
                    "type": "synonym"
                },
                {
                    "name": "MUC-1",
                    "type": "synonym"
                },
                {
                    "name": "MUC1/ZD",
                    "type": "synonym"
                },
                {
                    "name": "MUC1",
                    "type": "synonym"
                },
                {
                    "name": "PEMT",
                    "type": "synonym"
                },
                {
                    "name": "PEM",
                    "type": "synonym"
                },
                {
                    "name": "PUM",
                    "type": "synonym"
                }
            ],
            "record_id": "P15941-1",
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [
        {
            "biomarker_id": "BB3838-1",
            "biomarker_canonical_id": "BB3838",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Mucin-1",
                        "synonyms": [
                            {
                                "synonym": "Polymorphic epithelial mucin"
                            },
                            {
                                "synonym": "PEM"
                            },
                            {
                                "synonym": "Krebs von den Lungen-6"
                            },
                            {
                                "synonym": "KL-6"
                            },
                            {
                                "synonym": "Tumor-associated epithelial membrane antigen"
                            },
                            {
                                "synonym": "EMA"
                            },
                            {
                                "synonym": "Peanut-reactive urinary mucin"
                            },
                            {
                                "synonym": "PUM"
                            },
                            {
                                "synonym": "Cancer antigen 15-3"
                            },
                            {
                                "synonym": "CA 15-3"
                            },
                            {
                                "synonym": "Tumor-associated mucin"
                            },
                            {
                                "synonym": "MUC1-CT"
                            },
                            {
                                "synonym": "Breast carcinoma-associated antigen DF3"
                            },
                            {
                                "synonym": "PEMT"
                            },
                            {
                                "synonym": "Episialin"
                            },
                            {
                                "synonym": "Carcinoma-associated mucin"
                            },
                            {
                                "synonym": "H23AG"
                            }
                        ]
                    },
                    "biomarker": "increased level of MUCST on MUC1",
                    "assessed_biomarker_entity_id": "P15941-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3839-1",
            "biomarker_canonical_id": "BB3839",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Mucin-1",
                        "synonyms": [
                            {
                                "synonym": "Polymorphic epithelial mucin"
                            },
                            {
                                "synonym": "PEM"
                            },
                            {
                                "synonym": "Krebs von den Lungen-6"
                            },
                            {
                                "synonym": "KL-6"
                            },
                            {
                                "synonym": "Tumor-associated epithelial membrane antigen"
                            },
                            {
                                "synonym": "EMA"
                            },
                            {
                                "synonym": "Peanut-reactive urinary mucin"
                            },
                            {
                                "synonym": "PUM"
                            },
                            {
                                "synonym": "Cancer antigen 15-3"
                            },
                            {
                                "synonym": "CA 15-3"
                            },
                            {
                                "synonym": "Tumor-associated mucin"
                            },
                            {
                                "synonym": "MUC1-CT"
                            },
                            {
                                "synonym": "Breast carcinoma-associated antigen DF3"
                            },
                            {
                                "synonym": "PEMT"
                            },
                            {
                                "synonym": "Episialin"
                            },
                            {
                                "synonym": "Carcinoma-associated mucin"
                            },
                            {
                                "synonym": "H23AG"
                            }
                        ]
                    },
                    "biomarker": "increased level of core 1-glycan on MUC1",
                    "assessed_biomarker_entity_id": "P15941-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3840-1",
            "biomarker_canonical_id": "BB3840",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Mucin-1",
                        "synonyms": [
                            {
                                "synonym": "Polymorphic epithelial mucin"
                            },
                            {
                                "synonym": "PEM"
                            },
                            {
                                "synonym": "Krebs von den Lungen-6"
                            },
                            {
                                "synonym": "KL-6"
                            },
                            {
                                "synonym": "Tumor-associated epithelial membrane antigen"
                            },
                            {
                                "synonym": "EMA"
                            },
                            {
                                "synonym": "Peanut-reactive urinary mucin"
                            },
                            {
                                "synonym": "PUM"
                            },
                            {
                                "synonym": "Cancer antigen 15-3"
                            },
                            {
                                "synonym": "CA 15-3"
                            },
                            {
                                "synonym": "Tumor-associated mucin"
                            },
                            {
                                "synonym": "MUC1-CT"
                            },
                            {
                                "synonym": "Breast carcinoma-associated antigen DF3"
                            },
                            {
                                "synonym": "PEMT"
                            },
                            {
                                "synonym": "Episialin"
                            },
                            {
                                "synonym": "Carcinoma-associated mucin"
                            },
                            {
                                "synonym": "H23AG"
                            }
                        ]
                    },
                    "biomarker": "decreased level of MUCST on MUC1",
                    "assessed_biomarker_entity_id": "P15941-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3841-1",
            "biomarker_canonical_id": "BB3841",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Mucin-1",
                        "synonyms": [
                            {
                                "synonym": "Polymorphic epithelial mucin"
                            },
                            {
                                "synonym": "PEM"
                            },
                            {
                                "synonym": "Krebs von den Lungen-6"
                            },
                            {
                                "synonym": "KL-6"
                            },
                            {
                                "synonym": "Tumor-associated epithelial membrane antigen"
                            },
                            {
                                "synonym": "EMA"
                            },
                            {
                                "synonym": "Peanut-reactive urinary mucin"
                            },
                            {
                                "synonym": "PUM"
                            },
                            {
                                "synonym": "Cancer antigen 15-3"
                            },
                            {
                                "synonym": "CA 15-3"
                            },
                            {
                                "synonym": "Tumor-associated mucin"
                            },
                            {
                                "synonym": "MUC1-CT"
                            },
                            {
                                "synonym": "Breast carcinoma-associated antigen DF3"
                            },
                            {
                                "synonym": "PEMT"
                            },
                            {
                                "synonym": "Episialin"
                            },
                            {
                                "synonym": "Carcinoma-associated mucin"
                            },
                            {
                                "synonym": "H23AG"
                            }
                        ]
                    },
                    "biomarker": "increased level of MUCT on MUC1",
                    "assessed_biomarker_entity_id": "P15941-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        },
        {
            "biomarker_id": "BB3842-1",
            "biomarker_canonical_id": "BB3842",
            "best_biomarker_role": [
                {
                    "role": ""
                }
            ],
            "biomarker_component": [
                {
                    "assessed_biomarker_entity": {
                        "recommended_name": "Mucin-1",
                        "synonyms": [
                            {
                                "synonym": "Polymorphic epithelial mucin"
                            },
                            {
                                "synonym": "PEM"
                            },
                            {
                                "synonym": "Krebs von den Lungen-6"
                            },
                            {
                                "synonym": "KL-6"
                            },
                            {
                                "synonym": "Tumor-associated epithelial membrane antigen"
                            },
                            {
                                "synonym": "EMA"
                            },
                            {
                                "synonym": "Peanut-reactive urinary mucin"
                            },
                            {
                                "synonym": "PUM"
                            },
                            {
                                "synonym": "Cancer antigen 15-3"
                            },
                            {
                                "synonym": "CA 15-3"
                            },
                            {
                                "synonym": "Tumor-associated mucin"
                            },
                            {
                                "synonym": "MUC1-CT"
                            },
                            {
                                "synonym": "Breast carcinoma-associated antigen DF3"
                            },
                            {
                                "synonym": "PEMT"
                            },
                            {
                                "synonym": "Episialin"
                            },
                            {
                                "synonym": "Carcinoma-associated mucin"
                            },
                            {
                                "synonym": "H23AG"
                            }
                        ]
                    },
                    "biomarker": "increased level of core 2 on MUC1",
                    "assessed_biomarker_entity_id": "P15941-1",
                    "assessed_entity_type": "protein"
                }
            ],
            "evidence": [
                {
                    "id": "40492697",
                    "database": "PubMed",
                    "url": ""
                }
            ]
        }
    ],
    "association_flag": "1010",
    "record_id": "doid.0060548"
}