{
    "disease_id": "DOID:0060343",
    "recommended_name": {
        "id": "DOID:0060343",
        "resource": "Disease Ontology",
        "url": "https://disease-ontology.org/term/DOID:0060343",
        "name": "glucocorticoid-induced osteoporosis",
        "description": "An osteoporosis caused by chronic glucocorticoid use. Glucocorticoids impair the replication, differentiation and function of osteoblasts and induce the apoptosis of mature osteoblasts and osteocytes; the also favor osteoclastogenesis leading to an increase in bone resorption."
    },
    "synonyms": [
        {
            "id": "DOID:0060343",
            "resource": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060343",
            "name": "steroid-induced osteoporosis",
            "description": ""
        }
    ],
    "children": [],
    "id_list": [
        "DOID:0060343"
    ],
    "unlinked_id_list": [],
    "crossref": [
        {
            "id": "DOID:0060343",
            "database": "Disease Ontology",
            "url": "https://disease-ontology.org/term/DOID:0060343",
            "categories": []
        }
    ],
    "proteins": [
        {
            "uniprot_canonical_ac": "A0AB32T797-1",
            "uniprot_ac": "A0AB32T797",
            "uniprot_id": "A0AB32T797_DANRE",
            "refseq_ac": "XP_068070470",
            "glycoprotein": "no",
            "species": [
                {
                    "name": "Danio rerio",
                    "taxid": 7955,
                    "common_name": "Zebrafish",
                    "glygen_name": "Zebrafish",
                    "reference_species": "Danio rerio [7955]"
                }
            ],
            "protein_names": [
                {
                    "name": "Runt-related transcription factor",
                    "type": "recommended"
                },
                {
                    "name": "runt-related transcription factor 2 isoform X1",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "runx2a",
                    "type": "recommended"
                },
                {
                    "name": "runx2a",
                    "type": "synonym"
                }
            ],
            "record_id": "A0AB32T797-1",
            "evidence": [
                {
                    "id": "0060343",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060343"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q08775-1",
            "uniprot_ac": "Q08775",
            "uniprot_id": "RUNX2_MOUSE",
            "refseq_ac": "NP_001139510",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Mus musculus",
                    "taxid": 10090,
                    "common_name": "Mouse",
                    "glygen_name": "Mouse",
                    "reference_species": "Mus musculus [10090]"
                }
            ],
            "protein_names": [
                {
                    "name": "Runt-related transcription factor 2",
                    "type": "recommended"
                },
                {
                    "name": "AKV core binding factor",
                    "type": "synonym"
                },
                {
                    "name": "Acute myeloid leukemia 3 protein",
                    "type": "synonym"
                },
                {
                    "name": "CBF-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "Core-binding factor subunit alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "OSF-2",
                    "type": "synonym"
                },
                {
                    "name": "Oncogene AML-3",
                    "type": "synonym"
                },
                {
                    "name": "Osteoblast-specific transcription factor 2",
                    "type": "synonym"
                },
                {
                    "name": "PEA2-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2 alpha A",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "Polyomavirus enhancer-binding protein 2 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "SL3-3 enhancer factor 1 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "SL3/AKV core-binding factor alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "acute myeloid leukemia 3 protein",
                    "type": "synonym"
                },
                {
                    "name": "core binding factor alpha 1",
                    "type": "synonym"
                },
                {
                    "name": "osteoblast-specific transcription factor 2",
                    "type": "synonym"
                },
                {
                    "name": "polyomavirus enhancer-binding protein 2 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "runt domain, alpha subunit 1",
                    "type": "synonym"
                },
                {
                    "name": "runt-related transcription factor 2 isoform 1",
                    "type": "synonym"
                },
                {
                    "name": "transcription factor Cbfa1/Osf2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Runx2",
                    "type": "recommended"
                },
                {
                    "name": "AML3",
                    "type": "synonym"
                },
                {
                    "name": "Aml3",
                    "type": "synonym"
                },
                {
                    "name": "CBF-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "Cbfa-1",
                    "type": "synonym"
                },
                {
                    "name": "Cbfa1",
                    "type": "synonym"
                },
                {
                    "name": "Cbf",
                    "type": "synonym"
                },
                {
                    "name": "LS3",
                    "type": "synonym"
                },
                {
                    "name": "Osf2",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2aA",
                    "type": "synonym"
                },
                {
                    "name": "Pebp2a1",
                    "type": "synonym"
                },
                {
                    "name": "Pebp2a",
                    "type": "synonym"
                },
                {
                    "name": "Pebpa2a",
                    "type": "synonym"
                },
                {
                    "name": "Runx2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q08775-1",
            "evidence": [
                {
                    "id": "0060343",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060343"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q9Z2J9-1",
            "uniprot_ac": "Q9Z2J9",
            "uniprot_id": "RUNX2_RAT",
            "refseq_ac": "",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Rattus norvegicus",
                    "taxid": 10116,
                    "common_name": "Rat",
                    "glygen_name": "Rat",
                    "reference_species": "Rattus norvegicus [10116]"
                }
            ],
            "protein_names": [
                {
                    "name": "Runt-related transcription factor 2",
                    "type": "recommended"
                },
                {
                    "name": "CBF-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "Core-binding factor subunit alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "OSF-2",
                    "type": "synonym"
                },
                {
                    "name": "Osteoblast-specific transcription factor 2",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "Runx2",
                    "type": "recommended"
                },
                {
                    "name": "Cbfa1",
                    "type": "synonym"
                },
                {
                    "name": "Osf2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q9Z2J9-1",
            "evidence": [
                {
                    "id": "0060343",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060343"
                }
            ]
        },
        {
            "uniprot_canonical_ac": "Q13950-1",
            "uniprot_ac": "Q13950",
            "uniprot_id": "RUNX2_HUMAN",
            "refseq_ac": "NP_001015051",
            "glycoprotein": "yes",
            "species": [
                {
                    "name": "Homo sapiens",
                    "taxid": 9606,
                    "common_name": "Human",
                    "glygen_name": "Human",
                    "reference_species": "Homo sapiens [9606]"
                }
            ],
            "protein_names": [
                {
                    "name": "Runt-related transcription factor 2",
                    "type": "recommended"
                },
                {
                    "name": "Acute myeloid leukemia 3 protein",
                    "type": "synonym"
                },
                {
                    "name": "CBF-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "Core-binding factor subunit alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "OSF-2",
                    "type": "synonym"
                },
                {
                    "name": "Oncogene AML-3",
                    "type": "synonym"
                },
                {
                    "name": "Osteoblast-specific transcription factor 2",
                    "type": "synonym"
                },
                {
                    "name": "PEA2-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2-alpha A",
                    "type": "synonym"
                },
                {
                    "name": "Polyomavirus enhancer-binding protein 2 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "SL3-3 enhancer factor 1 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "SL3/AKV core-binding factor alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "acute myeloid leukemia 3 protein",
                    "type": "synonym"
                },
                {
                    "name": "core-binding factor, runt domain, alpha subunit 1",
                    "type": "synonym"
                },
                {
                    "name": "oncogene AML-3",
                    "type": "synonym"
                },
                {
                    "name": "osteoblast-specific transcription factor 2",
                    "type": "synonym"
                },
                {
                    "name": "polyomavirus enhancer-binding protein 2 alpha A subunit",
                    "type": "synonym"
                },
                {
                    "name": "runt related transcription factor 2",
                    "type": "synonym"
                },
                {
                    "name": "runt-related transcription factor 2 isoform b",
                    "type": "synonym"
                }
            ],
            "gene_names": [
                {
                    "name": "RUNX2",
                    "type": "recommended"
                },
                {
                    "name": "AML3",
                    "type": "synonym"
                },
                {
                    "name": "CBF-alpha-1",
                    "type": "synonym"
                },
                {
                    "name": "CBFA1",
                    "type": "synonym"
                },
                {
                    "name": "CCD1",
                    "type": "synonym"
                },
                {
                    "name": "CCD",
                    "type": "synonym"
                },
                {
                    "name": "CLCD",
                    "type": "synonym"
                },
                {
                    "name": "OSF-2",
                    "type": "synonym"
                },
                {
                    "name": "OSF2",
                    "type": "synonym"
                },
                {
                    "name": "PEA2aA",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2A",
                    "type": "synonym"
                },
                {
                    "name": "PEBP2aA",
                    "type": "synonym"
                },
                {
                    "name": "RUNX2",
                    "type": "synonym"
                }
            ],
            "record_id": "Q13950-1",
            "evidence": [
                {
                    "id": "0060343",
                    "database": "AGR",
                    "url": "https://www.alliancegenome.org/disease/DOID:0060343"
                }
            ]
        }
    ],
    "glycans": [],
    "biomarkers": [],
    "association_flag": "1000",
    "record_id": "doid.0060343"
}